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- Publisher Website: 10.1016/j.ijpara.2020.05.008
- Scopus: eid_2-s2.0-85087987690
- PMID: 32622688
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Article: Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression
Title | Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression |
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Authors | |
Keywords | Extracellular vesicles Host-parasite interactions MicroRNA Trichinella spiralis |
Issue Date | 2020 |
Citation | International Journal for Parasitology, 2020, v. 50, n. 9, p. 697-705 How to Cite? |
Abstract | Many organisms, including parasitic nematodes, secrete small RNAs into the extracellular environment, largely encapsulated within small vesicles. Parasite-secreted material often contains microRNAs (miRNAs), raising the possibility that they might regulate host genes in target cells. Here we characterise secreted RNAs from the parasitic nematode Trichinella spiralis at two different life stages. We show that adult T. spiralis, which inhabit intestinal mucosa, secrete miRNAs within vesicles. Unexpectedly, T. spiralis muscle stage larvae, which live intracellularly within skeletal muscle cells, secrete miRNAs that appear not to be encapsulated. Notably, secreted miRNAs include a homologue of mammalian miRNA-31, which has an important role in muscle development. Our work therefore suggests that RNAs may be secreted without encapsulation in vesicles, with implications for the biology of T. spiralis infection. |
Persistent Identifier | http://hdl.handle.net/10722/349443 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.111 |
DC Field | Value | Language |
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dc.contributor.author | Taylor, Peter J. | - |
dc.contributor.author | Hagen, Jana | - |
dc.contributor.author | Faruqu, Farid N. | - |
dc.contributor.author | Al-Jamal, Khuloud T. | - |
dc.contributor.author | Quigley, Bonnie | - |
dc.contributor.author | Beeby, Morgan | - |
dc.contributor.author | Selkirk, Murray E. | - |
dc.contributor.author | Sarkies, Peter | - |
dc.date.accessioned | 2024-10-17T06:58:34Z | - |
dc.date.available | 2024-10-17T06:58:34Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal for Parasitology, 2020, v. 50, n. 9, p. 697-705 | - |
dc.identifier.issn | 0020-7519 | - |
dc.identifier.uri | http://hdl.handle.net/10722/349443 | - |
dc.description.abstract | Many organisms, including parasitic nematodes, secrete small RNAs into the extracellular environment, largely encapsulated within small vesicles. Parasite-secreted material often contains microRNAs (miRNAs), raising the possibility that they might regulate host genes in target cells. Here we characterise secreted RNAs from the parasitic nematode Trichinella spiralis at two different life stages. We show that adult T. spiralis, which inhabit intestinal mucosa, secrete miRNAs within vesicles. Unexpectedly, T. spiralis muscle stage larvae, which live intracellularly within skeletal muscle cells, secrete miRNAs that appear not to be encapsulated. Notably, secreted miRNAs include a homologue of mammalian miRNA-31, which has an important role in muscle development. Our work therefore suggests that RNAs may be secreted without encapsulation in vesicles, with implications for the biology of T. spiralis infection. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal for Parasitology | - |
dc.subject | Extracellular vesicles | - |
dc.subject | Host-parasite interactions | - |
dc.subject | MicroRNA | - |
dc.subject | Trichinella spiralis | - |
dc.title | Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ijpara.2020.05.008 | - |
dc.identifier.pmid | 32622688 | - |
dc.identifier.scopus | eid_2-s2.0-85087987690 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 697 | - |
dc.identifier.epage | 705 | - |
dc.identifier.eissn | 1879-0135 | - |