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- Publisher Website: 10.21037/abs-21-45
- Scopus: eid_2-s2.0-85212038100
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Article: Recent trends in nipple sparing mastectomy — a narrative review
Title | Recent trends in nipple sparing mastectomy — a narrative review |
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Authors | |
Keywords | BRCA breast cancer Nipple sparing mastectomy (NSM) |
Issue Date | 30-Mar-2024 |
Citation | Annals of Breast Surgery, 2024, v. 8 How to Cite? |
Abstract | Background and Objective: Nipple sparing mastectomy (NSM) has become increasingly popular in recent years, both as a treatment for selected cases of breast cancer and for BRCA carriers in prophylactic and therapeutic use. Methods: PubMed, EMBASE, CINAHL and Cochrane were searched for studies on NSM up till June 2020. Key Content and Findings: Different incisions are indicated in different situations and the ultimate decision should be reached after a multi-disciplinary discussion. A common complication of NSM is nipple areolar complex (NAC) necrosis. Therefore, it is imperative for its blood supply to be preserved as much as possible. A deeper understanding of the breast vasculature would also be useful in planning future surgical approach. While NSM offers a superb cosmetic outcome, oncological safety should never be compromised. Short term oncological safety for NSM is evident in recently conducted studies. Three major parameters were evaluated including overall survival, disease-free survival (DFS) and local recurrence rates. In general, NSM is associated with high DFS and low recurrence. As such, carefully selected breast cancer patients and high-risk BRCA patients would benefit from NSM despite occult NAC malignancy being a concern. Conclusions: NSM offers a non-inferior outcome to the conventional mastectomy in selected cases. In the future, randomised controlled trials (RCTs) would be useful in demonstrating the long-term oncologic safety of NSM in breast cancer and BRCA-carrier patients. |
Persistent Identifier | http://hdl.handle.net/10722/352790 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, Kwong Yee Chloe | - |
dc.contributor.author | Co, Michael | - |
dc.date.accessioned | 2025-01-06T00:35:15Z | - |
dc.date.available | 2025-01-06T00:35:15Z | - |
dc.date.issued | 2024-03-30 | - |
dc.identifier.citation | Annals of Breast Surgery, 2024, v. 8 | - |
dc.identifier.uri | http://hdl.handle.net/10722/352790 | - |
dc.description.abstract | <p>Background and Objective: Nipple sparing mastectomy (NSM) has become increasingly popular in recent years, both as a treatment for selected cases of breast cancer and for BRCA carriers in prophylactic and therapeutic use. Methods: PubMed, EMBASE, CINAHL and Cochrane were searched for studies on NSM up till June 2020. Key Content and Findings: Different incisions are indicated in different situations and the ultimate decision should be reached after a multi-disciplinary discussion. A common complication of NSM is nipple areolar complex (NAC) necrosis. Therefore, it is imperative for its blood supply to be preserved as much as possible. A deeper understanding of the breast vasculature would also be useful in planning future surgical approach. While NSM offers a superb cosmetic outcome, oncological safety should never be compromised. Short term oncological safety for NSM is evident in recently conducted studies. Three major parameters were evaluated including overall survival, disease-free survival (DFS) and local recurrence rates. In general, NSM is associated with high DFS and low recurrence. As such, carefully selected breast cancer patients and high-risk BRCA patients would benefit from NSM despite occult NAC malignancy being a concern. Conclusions: NSM offers a non-inferior outcome to the conventional mastectomy in selected cases. In the future, randomised controlled trials (RCTs) would be useful in demonstrating the long-term oncologic safety of NSM in breast cancer and BRCA-carrier patients.</p> | - |
dc.language | eng | - |
dc.relation.ispartof | Annals of Breast Surgery | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | BRCA | - |
dc.subject | breast cancer | - |
dc.subject | Nipple sparing mastectomy (NSM) | - |
dc.title | Recent trends in nipple sparing mastectomy — a narrative review | - |
dc.type | Article | - |
dc.identifier.doi | 10.21037/abs-21-45 | - |
dc.identifier.scopus | eid_2-s2.0-85212038100 | - |
dc.identifier.volume | 8 | - |
dc.identifier.eissn | 2616-2776 | - |
dc.identifier.issnl | 2616-2776 | - |