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Article: Recent trends in nipple sparing mastectomy — a narrative review

TitleRecent trends in nipple sparing mastectomy — a narrative review
Authors
KeywordsBRCA
breast cancer
Nipple sparing mastectomy (NSM)
Issue Date30-Mar-2024
Citation
Annals of Breast Surgery, 2024, v. 8 How to Cite?
Abstract

Background and Objective: Nipple sparing mastectomy (NSM) has become increasingly popular in recent years, both as a treatment for selected cases of breast cancer and for BRCA carriers in prophylactic and therapeutic use. Methods: PubMed, EMBASE, CINAHL and Cochrane were searched for studies on NSM up till June 2020. Key Content and Findings: Different incisions are indicated in different situations and the ultimate decision should be reached after a multi-disciplinary discussion. A common complication of NSM is nipple areolar complex (NAC) necrosis. Therefore, it is imperative for its blood supply to be preserved as much as possible. A deeper understanding of the breast vasculature would also be useful in planning future surgical approach. While NSM offers a superb cosmetic outcome, oncological safety should never be compromised. Short term oncological safety for NSM is evident in recently conducted studies. Three major parameters were evaluated including overall survival, disease-free survival (DFS) and local recurrence rates. In general, NSM is associated with high DFS and low recurrence. As such, carefully selected breast cancer patients and high-risk BRCA patients would benefit from NSM despite occult NAC malignancy being a concern. Conclusions: NSM offers a non-inferior outcome to the conventional mastectomy in selected cases. In the future, randomised controlled trials (RCTs) would be useful in demonstrating the long-term oncologic safety of NSM in breast cancer and BRCA-carrier patients.


Persistent Identifierhttp://hdl.handle.net/10722/352790

 

DC FieldValueLanguage
dc.contributor.authorCheung, Kwong Yee Chloe-
dc.contributor.authorCo, Michael-
dc.date.accessioned2025-01-06T00:35:15Z-
dc.date.available2025-01-06T00:35:15Z-
dc.date.issued2024-03-30-
dc.identifier.citationAnnals of Breast Surgery, 2024, v. 8-
dc.identifier.urihttp://hdl.handle.net/10722/352790-
dc.description.abstract<p>Background and Objective: Nipple sparing mastectomy (NSM) has become increasingly popular in recent years, both as a treatment for selected cases of breast cancer and for BRCA carriers in prophylactic and therapeutic use. Methods: PubMed, EMBASE, CINAHL and Cochrane were searched for studies on NSM up till June 2020. Key Content and Findings: Different incisions are indicated in different situations and the ultimate decision should be reached after a multi-disciplinary discussion. A common complication of NSM is nipple areolar complex (NAC) necrosis. Therefore, it is imperative for its blood supply to be preserved as much as possible. A deeper understanding of the breast vasculature would also be useful in planning future surgical approach. While NSM offers a superb cosmetic outcome, oncological safety should never be compromised. Short term oncological safety for NSM is evident in recently conducted studies. Three major parameters were evaluated including overall survival, disease-free survival (DFS) and local recurrence rates. In general, NSM is associated with high DFS and low recurrence. As such, carefully selected breast cancer patients and high-risk BRCA patients would benefit from NSM despite occult NAC malignancy being a concern. Conclusions: NSM offers a non-inferior outcome to the conventional mastectomy in selected cases. In the future, randomised controlled trials (RCTs) would be useful in demonstrating the long-term oncologic safety of NSM in breast cancer and BRCA-carrier patients.</p>-
dc.languageeng-
dc.relation.ispartofAnnals of Breast Surgery-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBRCA-
dc.subjectbreast cancer-
dc.subjectNipple sparing mastectomy (NSM)-
dc.titleRecent trends in nipple sparing mastectomy — a narrative review-
dc.typeArticle-
dc.identifier.doi10.21037/abs-21-45-
dc.identifier.scopuseid_2-s2.0-85212038100-
dc.identifier.volume8-
dc.identifier.eissn2616-2776-
dc.identifier.issnl2616-2776-

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