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Article: Global Practices and Preferences in the Use of Osteobiologics for Anterior Cervical Discectomy and Fusion: A Cross-Sectional Study
Title | Global Practices and Preferences in the Use of Osteobiologics for Anterior Cervical Discectomy and Fusion: A Cross-Sectional Study |
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Authors | Ambrosio, LucaViswanadha, Arun KumarVergroesen, Pieter-Paul A.Buser, ZoricaMeisel, Hans JoergSantesso, NancyCheung, Jason P. Y.Le, Hai V.Vadalà, GianlucaJain, AmitDemetriades, Andreas K.Cho, Sam K.Hsieh, Patrick C.Diwan, Ashish D.Martin, ChristopherYoon, TimMuthu, SathishAO Spine Knowledge Forum Degenerative |
Issue Date | 19-Feb-2025 |
Publisher | SAGE Publications |
Citation | Global Spine Journal, 2025 How to Cite? |
Abstract | Study DesignCross-sectional study. ObjectivesTo assess global practices and preferences in the use of osteobiologics for anterior cervical discectomy and fusion (ACDF) and identify factors influencing the choice of specific osteobiologics. MethodsAn online survey developed by AO Spine was distributed to spine surgeons worldwide. The survey captured demographic characteristics, osteobiologic use and related information (i.e., previous training, practice patterns, etc.), and factors influencing osteobiologic choice in ACDF. Descriptive statistics, Chi-square tests, and multiple logistic regression were used to analyze responses, focusing on the associations between osteobiologic use and variables such as training, cost awareness, and regional practices. ResultsResponses from 458 surgeons revealed regional variability in osteobiologic preferences. Autologous iliac crest bone graft (AICBG) was predominant in Asia Pacific and Middle East, while allograft and demineralized bone matrix were favored in North America and Latin America (P < 0.0001). Over half of the respondents (79.7%) lacked formal training in osteobiologics, and 53.1% were unaware of related costs. Surgeons residing in the Asia Pacific region (OR: 0.47, 95% CI: 0.26-0.84, P = 0.0114), without formal training (OR: 0.53, 95% CI: 0.29-0.97, P = 0.0429), or using cages less often (OR: 0.15, 95% CI: 0.06-0.34, P < 0.0001) were less likely to utilize osteobiologics. Osteobiologic use was also more common when related costs were not an issue for the practitioner (OR: 2.32, 95% CI:1.47-3.70, P = 0.0004). ConclusionsSignificant variation exists in osteobiologic use in ACDF across global regions, influenced by surgeon training, cost awareness, and institutional resources. Enhanced training and guidelines could improve consistency in osteobiologic application. |
Persistent Identifier | http://hdl.handle.net/10722/354937 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.264 |
DC Field | Value | Language |
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dc.contributor.author | Ambrosio, Luca | - |
dc.contributor.author | Viswanadha, Arun Kumar | - |
dc.contributor.author | Vergroesen, Pieter-Paul A. | - |
dc.contributor.author | Buser, Zorica | - |
dc.contributor.author | Meisel, Hans Joerg | - |
dc.contributor.author | Santesso, Nancy | - |
dc.contributor.author | Cheung, Jason P. Y. | - |
dc.contributor.author | Le, Hai V. | - |
dc.contributor.author | Vadalà, Gianluca | - |
dc.contributor.author | Jain, Amit | - |
dc.contributor.author | Demetriades, Andreas K. | - |
dc.contributor.author | Cho, Sam K. | - |
dc.contributor.author | Hsieh, Patrick C. | - |
dc.contributor.author | Diwan, Ashish D. | - |
dc.contributor.author | Martin, Christopher | - |
dc.contributor.author | Yoon, Tim | - |
dc.contributor.author | Muthu, Sathish | - |
dc.contributor.author | AO Spine Knowledge Forum Degenerative | - |
dc.date.accessioned | 2025-03-18T00:35:28Z | - |
dc.date.available | 2025-03-18T00:35:28Z | - |
dc.date.issued | 2025-02-19 | - |
dc.identifier.citation | Global Spine Journal, 2025 | - |
dc.identifier.issn | 2192-5682 | - |
dc.identifier.uri | http://hdl.handle.net/10722/354937 | - |
dc.description.abstract | <h3>Study Design</h3><p>Cross-sectional study.</p><h3>Objectives</h3><p>To assess global practices and preferences in the use of osteobiologics for anterior cervical discectomy and fusion (ACDF) and identify factors influencing the choice of specific osteobiologics.</p><h3>Methods</h3><p>An online survey developed by AO Spine was distributed to spine surgeons worldwide. The survey captured demographic characteristics, osteobiologic use and related information (i.e., previous training, practice patterns, etc.), and factors influencing osteobiologic choice in ACDF. Descriptive statistics, Chi-square tests, and multiple logistic regression were used to analyze responses, focusing on the associations between osteobiologic use and variables such as training, cost awareness, and regional practices.</p><h3>Results</h3><p>Responses from 458 surgeons revealed regional variability in osteobiologic preferences. Autologous iliac crest bone graft (AICBG) was predominant in Asia Pacific and Middle East, while allograft and demineralized bone matrix were favored in North America and Latin America (<em>P</em> < 0.0001). Over half of the respondents (79.7%) lacked formal training in osteobiologics, and 53.1% were unaware of related costs. Surgeons residing in the Asia Pacific region (OR: 0.47, 95% CI: 0.26-0.84, <em>P</em> = 0.0114), without formal training (OR: 0.53, 95% CI: 0.29-0.97, <em>P</em> = 0.0429), or using cages less often (OR: 0.15, 95% CI: 0.06-0.34, <em>P</em> < 0.0001) were less likely to utilize osteobiologics. Osteobiologic use was also more common when related costs were not an issue for the practitioner (OR: 2.32, 95% CI:1.47-3.70, <em>P</em> = 0.0004).</p><h3>Conclusions</h3><p>Significant variation exists in osteobiologic use in ACDF across global regions, influenced by surgeon training, cost awareness, and institutional resources. Enhanced training and guidelines could improve consistency in osteobiologic application.</p> | - |
dc.language | eng | - |
dc.publisher | SAGE Publications | - |
dc.relation.ispartof | Global Spine Journal | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Global Practices and Preferences in the Use of Osteobiologics for Anterior Cervical Discectomy and Fusion: A Cross-Sectional Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/21925682251322417 | - |
dc.identifier.eissn | 2192-5690 | - |
dc.identifier.issnl | 2192-5682 | - |