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- Publisher Website: 10.1055/a-2160-7887
- Scopus: eid_2-s2.0-85170838527
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Article: Construction of Vicinal Stereocenters via Asymmetric Cyanosilylation
| Title | Construction of Vicinal Stereocenters via Asymmetric Cyanosilylation |
|---|---|
| Authors | |
| Keywords | asymmetric addition cyanosilylation desymmetrization kinetic resolution quaternary stereocenters vicinal stereocenters |
| Issue Date | 1-Jan-2023 |
| Publisher | Thieme Publishing / Georg Thieme Verlag |
| Citation | Accounts and Rapid Communications in Chemical Synthesis, 2023, v. 35, n. 12, p. 1327-1332 How to Cite? |
| Abstract | Asymmetric cyanosilylation serves as an important tool to convert easily available ketones to cyanohydrins of diverse reactivity. While a large library of organo- and transition metal catalysts have been identified for mono-ketones, cyanosilylation of more complex substrates, particularly those giving enantioenriched vicinal stereocenters, is underexplored in comparison. Here, a pair of recently published kinetic resolution and desymmetrization methods are highlighted for their success in constructing complex vicinal stereocenters via cyanosilylation using tailored aluminum and magnesium catalysts, respectively. |
| Persistent Identifier | http://hdl.handle.net/10722/355367 |
| ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.450 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Huang, Zhongxing | - |
| dc.date.accessioned | 2025-04-08T00:35:06Z | - |
| dc.date.available | 2025-04-08T00:35:06Z | - |
| dc.date.issued | 2023-01-01 | - |
| dc.identifier.citation | Accounts and Rapid Communications in Chemical Synthesis, 2023, v. 35, n. 12, p. 1327-1332 | - |
| dc.identifier.issn | 0936-5214 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/355367 | - |
| dc.description.abstract | Asymmetric cyanosilylation serves as an important tool to convert easily available ketones to cyanohydrins of diverse reactivity. While a large library of organo- and transition metal catalysts have been identified for mono-ketones, cyanosilylation of more complex substrates, particularly those giving enantioenriched vicinal stereocenters, is underexplored in comparison. Here, a pair of recently published kinetic resolution and desymmetrization methods are highlighted for their success in constructing complex vicinal stereocenters via cyanosilylation using tailored aluminum and magnesium catalysts, respectively. | - |
| dc.language | eng | - |
| dc.publisher | Thieme Publishing / Georg Thieme Verlag | - |
| dc.relation.ispartof | Accounts and Rapid Communications in Chemical Synthesis | - |
| dc.subject | asymmetric addition | - |
| dc.subject | cyanosilylation | - |
| dc.subject | desymmetrization | - |
| dc.subject | kinetic resolution | - |
| dc.subject | quaternary stereocenters | - |
| dc.subject | vicinal stereocenters | - |
| dc.title | Construction of Vicinal Stereocenters via Asymmetric Cyanosilylation | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1055/a-2160-7887 | - |
| dc.identifier.scopus | eid_2-s2.0-85170838527 | - |
| dc.identifier.volume | 35 | - |
| dc.identifier.issue | 12 | - |
| dc.identifier.spage | 1327 | - |
| dc.identifier.epage | 1332 | - |
| dc.identifier.eissn | 1437-2096 | - |
| dc.identifier.issnl | 0936-5214 | - |