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Article: Emerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications.

TitleEmerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications.
Authors
Wang, JiaqiMan, KwanNg, Kevin Tak-Pan
Keywordscancer
chemokine CCL11
inflammation
liver disease
therapeutic target
Issue Date13-May-2025
PublisherMDPI
Citation
International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4662 How to Cite?
DOI: http://dx.doi.org/10.3390/ijms26104662
Abstract

C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer progression. In liver diseases, it mediates injury, fibrosis, and inflammation while serving as a disease biomarker. This review systematically examines CCL11-receptor interactions and their immunomodulatory mechanisms in cancers and hepatic pathologies. We highlight CCL11's therapeutic potential as both a prognostic marker and immunotherapeutic target. By integrating molecular and clinical insights, this work advances the understanding of CCL11's pathophysiological roles and facilitates targeted therapy development.


Persistent Identifierhttp://hdl.handle.net/10722/356661
ISSN
1661-6596
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID
WOS:001496480100001

 

DC FieldValueLanguage
dc.contributor.authorWang, Jiaqi-
dc.contributor.authorMan, Kwan-
dc.contributor.authorNg, Kevin Tak-Pan-
dc.date.accessioned2025-06-08T00:35:14Z-
dc.date.available2025-06-08T00:35:14Z-
dc.date.issued2025-05-13-
dc.identifier.citationInternational Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4662-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/356661-
dc.description.abstract<p>C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer progression. In liver diseases, it mediates injury, fibrosis, and inflammation while serving as a disease biomarker. This review systematically examines CCL11-receptor interactions and their immunomodulatory mechanisms in cancers and hepatic pathologies. We highlight CCL11's therapeutic potential as both a prognostic marker and immunotherapeutic target. By integrating molecular and clinical insights, this work advances the understanding of CCL11's pathophysiological roles and facilitates targeted therapy development.<br></p>-
dc.languageeng-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcancer-
dc.subjectchemokine CCL11-
dc.subjectinflammation-
dc.subjectliver disease-
dc.subjecttherapeutic target-
dc.titleEmerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications.-
dc.typeArticle-
dc.identifier.doi10.3390/ijms26104662-
dc.identifier.scopuseid_2-s2.0-105006746214-
dc.identifier.volume26-
dc.identifier.issue10-
dc.identifier.spage4662-
dc.identifier.eissn1422-0067-
dc.identifier.isiWOS:001496480100001-
dc.identifier.issnl1422-0067-

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