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Article: Unraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications

TitleUnraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications
Authors
Liang, ZixinLi, ShanshanWang, ZhiyuZhou, JuntingHuang, ZiyueLi, JiehanBao, HaolinYam, Judy Wai PingXu, Yi
KeywordsHepatocellular carcinoma
Invasion
Metastasis
Pathogenesis
Proliferation
Therapy
Wnt signaling
Issue Date1-Apr-2025
PublisherXia & He Publishing Inc.
Citation
Journal of Clinical and Translational Hepatology, 2025, v. 13, n. 4, p. 315-326 How to Cite?
DOI: http://dx.doi.org/10.14218/JCTH.2024.00401
AbstractHepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on understanding its pathogenesis and developing treatments.The Wnt signaling pathway, a complex and evolutionarily conserved signal transduction system, has been extensively studied in the genesis and treatment of several malignant tumors. Recent investigations suggest that the pathogenesis of HCC may be significantly influenced by dysregulated Wnt/β-catenin signaling. This article aimed to examine the pathway that controls Wnt signaling in HCC and its mechanisms. In addition, we highlighted the role of this pathway in HCC etiology and targeted treatment.
Persistent Identifierhttp://hdl.handle.net/10722/369650
ISSN
2225-0719
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.988

 

DC FieldValueLanguage
dc.contributor.authorLiang, Zixin-
dc.contributor.authorLi, Shanshan-
dc.contributor.authorWang, Zhiyu-
dc.contributor.authorZhou, Junting-
dc.contributor.authorHuang, Ziyue-
dc.contributor.authorLi, Jiehan-
dc.contributor.authorBao, Haolin-
dc.contributor.authorYam, Judy Wai Ping-
dc.contributor.authorXu, Yi-
dc.date.accessioned2026-01-30T00:35:42Z-
dc.date.available2026-01-30T00:35:42Z-
dc.date.issued2025-04-01-
dc.identifier.citationJournal of Clinical and Translational Hepatology, 2025, v. 13, n. 4, p. 315-326-
dc.identifier.issn2225-0719-
dc.identifier.urihttp://hdl.handle.net/10722/369650-
dc.description.abstractHepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on understanding its pathogenesis and developing treatments.The Wnt signaling pathway, a complex and evolutionarily conserved signal transduction system, has been extensively studied in the genesis and treatment of several malignant tumors. Recent investigations suggest that the pathogenesis of HCC may be significantly influenced by dysregulated Wnt/β-catenin signaling. This article aimed to examine the pathway that controls Wnt signaling in HCC and its mechanisms. In addition, we highlighted the role of this pathway in HCC etiology and targeted treatment.-
dc.languageeng-
dc.publisherXia & He Publishing Inc.-
dc.relation.ispartofJournal of Clinical and Translational Hepatology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHepatocellular carcinoma-
dc.subjectInvasion-
dc.subjectMetastasis-
dc.subjectPathogenesis-
dc.subjectProliferation-
dc.subjectTherapy-
dc.subjectWnt signaling-
dc.titleUnraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications-
dc.typeArticle-
dc.identifier.doi10.14218/JCTH.2024.00401-
dc.identifier.scopuseid_2-s2.0-105003193783-
dc.identifier.volume13-
dc.identifier.issue4-
dc.identifier.spage315-
dc.identifier.epage326-
dc.identifier.eissn2310-8819-
dc.identifier.issnl2225-0719-

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