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Article: Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1
Title | Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1 |
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Authors | |
Issue Date | 2003 |
Publisher | Oxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org |
Citation | Journal Of Infectious Diseases, 2003, v. 187 n. 7, p. 1071-1074 How to Cite? |
Abstract | Because there is a lack of data on the treatment outcome of patients who carry hepatitis C virus (HCV) genotype 6, we conducted a prospective study, to compare the effect of interferon and ribavirin therapy in HCV genotypes 1 and 6, of patients with seropositive anti-HCV, persistently elevated alanine transaminase levels, and detectable HCV RNA. Patients were treated with subcutaneous recombinant interferon α-2b and ribavirin for 12 months. Of 40 patients, 16 had genotype 6, and 24 had genotype 1. An end-of-treatment response was detected in 12 (75%) patients with genotype 6 and in 10 (41.6%) patients with genotype 1 (P = .05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P = .04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR. |
Persistent Identifier | http://hdl.handle.net/10722/42154 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Hui, CK | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.contributor.author | Sablon, E | en_HK |
dc.contributor.author | Chan, AOO | en_HK |
dc.contributor.author | Wong, BCY | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.date.accessioned | 2007-01-08T02:30:24Z | - |
dc.date.available | 2007-01-08T02:30:24Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Journal Of Infectious Diseases, 2003, v. 187 n. 7, p. 1071-1074 | en_HK |
dc.identifier.issn | 0022-1899 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/42154 | - |
dc.description.abstract | Because there is a lack of data on the treatment outcome of patients who carry hepatitis C virus (HCV) genotype 6, we conducted a prospective study, to compare the effect of interferon and ribavirin therapy in HCV genotypes 1 and 6, of patients with seropositive anti-HCV, persistently elevated alanine transaminase levels, and detectable HCV RNA. Patients were treated with subcutaneous recombinant interferon α-2b and ribavirin for 12 months. Of 40 patients, 16 had genotype 6, and 24 had genotype 1. An end-of-treatment response was detected in 12 (75%) patients with genotype 6 and in 10 (41.6%) patients with genotype 1 (P = .05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P = .04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR. | en_HK |
dc.format.extent | 85405 bytes | - |
dc.format.extent | 3035 bytes | - |
dc.format.extent | 2319 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org | en_HK |
dc.relation.ispartof | Journal of Infectious Diseases | en_HK |
dc.rights | Journal of Infectious Diseases. Copyright © University of Chicago Press. | en_HK |
dc.subject.mesh | Antiviral agents - therapeutic use | en_HK |
dc.subject.mesh | Hepacivirus - drug effects - genetics | en_HK |
dc.subject.mesh | Hepatitis c, chronic - drug therapy - virology | en_HK |
dc.subject.mesh | Interferon alfa-2b - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | Ribavirin - pharmacology - therapeutic use | en_HK |
dc.title | Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1 | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=187&issue=7&spage=1071&epage=1074&date=2003&atitle=Interferon+and+Ribavirin+Therapy+for+Chronic+Hepatitis+C+Virus+Genotype+6:+A+Comparison+with+Genotype+1 | en_HK |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, BCY:bcywong@hku.hk | en_HK |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.identifier.authority | Wong, BCY=rp00429 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1086/368217 | en_HK |
dc.identifier.pmid | 12660921 | - |
dc.identifier.scopus | eid_2-s2.0-0037385492 | en_HK |
dc.identifier.hkuros | 80554 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037385492&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 187 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 1071 | en_HK |
dc.identifier.epage | 1074 | en_HK |
dc.identifier.isi | WOS:000181713000006 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Hui, CK=7202876933 | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.scopusauthorid | Sablon, E=6603694538 | en_HK |
dc.identifier.scopusauthorid | Chan, AOO=7403167965 | en_HK |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.issnl | 0022-1899 | - |