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Article: A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

TitleA polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7
Authors
Knowlton, RGCohen-Haguenauer, ONguyen, VanFrezal, JBrown, VBarker, DBraman, JCSchumm, JWTsui, L-CBuchwald, MDonis-Keller, H
Issue Date1985
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1985, v. 318 n. 6044, p. 380-382 How to Cite?
DOI: http://dx.doi.org/10.1038/318380a0
AbstractAlthough cystic fibrosis (CF) is among the most common inherited diseases in Caucasian populations, the basic biochemical defect is not yet known. CF is inherited as an autosomal recessive trait apparently due to mutations in a single gene, whence the efforts made to identify the genetic locus responsible by linkage studies. Two markers have recently been identified that are genetically linked to CF: one is a genetic variation in serum level of activity of the enzyme paraoxonase, and the other is a restriction fragment length polymorphism (RFLP) identified with a randomly isolated DNA probe. We report here that the genetic locus DOCRI-917 defined by the cloned DNA probe is located on chromosome 7.
Persistent Identifierhttp://hdl.handle.net/10722/44215
ISSN
0028-0836
2023 Impact Factor: 50.5
2023 SCImago Journal Rankings: 18.509
ISI Accession Number ID
WOS:A1985AVC5500066

 

DC FieldValueLanguage
dc.contributor.authorKnowlton, RGen_HK
dc.contributor.authorCohen-Haguenauer, Oen_HK
dc.contributor.authorNguyen, Vanen_HK
dc.contributor.authorFrezal, Jen_HK
dc.contributor.authorBrown, Ven_HK
dc.contributor.authorBarker, Den_HK
dc.contributor.authorBraman, JCen_HK
dc.contributor.authorSchumm, JWen_HK
dc.contributor.authorTsui, L-Cen_HK
dc.contributor.authorBuchwald, Men_HK
dc.contributor.authorDonis-Keller, Hen_HK
dc.date.accessioned2007-09-12T03:49:10Z-
dc.date.available2007-09-12T03:49:10Z-
dc.date.issued1985en_HK
dc.identifier.citationNature, 1985, v. 318 n. 6044, p. 380-382en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44215-
dc.description.abstractAlthough cystic fibrosis (CF) is among the most common inherited diseases in Caucasian populations, the basic biochemical defect is not yet known. CF is inherited as an autosomal recessive trait apparently due to mutations in a single gene, whence the efforts made to identify the genetic locus responsible by linkage studies. Two markers have recently been identified that are genetically linked to CF: one is a genetic variation in serum level of activity of the enzyme paraoxonase, and the other is a restriction fragment length polymorphism (RFLP) identified with a randomly isolated DNA probe. We report here that the genetic locus DOCRI-917 defined by the cloned DNA probe is located on chromosome 7.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNature-
dc.subject.meshChromosome mappingen_HK
dc.subject.meshChromosomes, human, 6-12 and xen_HK
dc.subject.meshCystic fibrosis - geneticsen_HK
dc.subject.meshDna restriction enzymes - diagnostic useen_HK
dc.subject.meshPolymorphism, geneticen_HK
dc.titleA polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7en_HK
dc.typeArticleen_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1038/318380a0-
dc.identifier.pmid2999611-
dc.identifier.scopuseid_2-s2.0-0022413731-
dc.identifier.isiWOS:A1985AVC5500066-
dc.identifier.issnl0028-0836-

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