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- Publisher Website: 10.1152/physiolgenomics.00114.2002
- Scopus: eid_2-s2.0-0037678280
- PMID: 12441405
- WOS: WOS:000180400100003
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Article: Loci of intestinal distress in cystic fibrosis knockout mice
Title | Loci of intestinal distress in cystic fibrosis knockout mice |
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Authors | |
Keywords | Modifier gene Transmission distortion |
Issue Date | 2003 |
Publisher | American Physiological Society. |
Citation | Physiological Genomics, 2003, v. 12, p. 79-84 How to Cite? |
Abstract | The strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 × 10-4) to predict for intestinal distress in CF male mice. An × chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype. |
Persistent Identifier | http://hdl.handle.net/10722/44379 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.999 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Haston, CK | en_HK |
dc.contributor.author | Tsui, LC | en_HK |
dc.date.accessioned | 2007-09-12T03:52:24Z | - |
dc.date.available | 2007-09-12T03:52:24Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Physiological Genomics, 2003, v. 12, p. 79-84 | en_HK |
dc.identifier.issn | 1531-2267 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/44379 | - |
dc.description.abstract | The strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 × 10-4) to predict for intestinal distress in CF male mice. An × chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype. | en_HK |
dc.language | eng | en_HK |
dc.publisher | American Physiological Society. | en_HK |
dc.relation.ispartof | Physiological Genomics | en_HK |
dc.subject | Modifier gene | en_HK |
dc.subject | Transmission distortion | en_HK |
dc.subject.mesh | Cystic fibrosis - genetics - physiopathology | en_HK |
dc.subject.mesh | Cystic fibrosis transmembrane conductance regulator - deficiency - genetics | en_HK |
dc.subject.mesh | Genetic markers - genetics - physiology | en_HK |
dc.subject.mesh | Intestinal diseases - genetics - physiopathology | en_HK |
dc.subject.mesh | Mice, inbred balb c | en_HK |
dc.title | Loci of intestinal distress in cystic fibrosis knockout mice | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Tsui, LC: tsuilc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tsui, LC=rp00058 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_HK |
dc.identifier.doi | 10.1152/physiolgenomics.00114.2002 | en_HK |
dc.identifier.pmid | 12441405 | - |
dc.identifier.scopus | eid_2-s2.0-0037678280 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037678280&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 12 | en_HK |
dc.identifier.spage | 79 | en_HK |
dc.identifier.epage | 84 | en_HK |
dc.identifier.isi | WOS:000180400100003 | - |
dc.identifier.scopusauthorid | Haston, CK=6602880337 | en_HK |
dc.identifier.scopusauthorid | Tsui, LC=7102754167 | en_HK |
dc.identifier.issnl | 1094-8341 | - |