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Conference Paper: MRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors
Title | MRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors |
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Authors | |
Keywords | Medical sciences Computer applications |
Issue Date | 2005 |
Publisher | IEEE. |
Citation | Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2005, v. 7 VOLS, p. 7044-7047 How to Cite? |
Abstract | MRI and image quantitation play an expanding role in modern drug research, because MRI offers high resolution and non-invasive ability, and provides excellent soft tissue contrast. Moreover, with development of effective image segmentation and analysis methods, in-vivo and serial tissue growth measurements could be assessed. In the study, MR image acquisition and analysis protocol were established and validated for investigating the effects of anabolic steroids and precursors on muscle growth and body composition in a guinea pig model. Semi-automatic and interactive segmentation methods were developed to accurately label the tissue of interest for tissue volume estimation. In addition, a longitudinal tissue area outlining procedure was proposed for study of tissue geometric features in relation to tissue growth. Finally, a fully automatic data retrieval and analysis scheme was implemented to facilitate the overall huge amount of image quantitation, statistical analysis, as well as study group comparisons. As a result, highly significant differences in muscle and organ growth were detected between intact and castrated guinea pigs using the selected anabolic steroids, indicating the viability of employing such protocol to assess other anabolic steroids. Furthermore, the anabolic potential of selected steroid precursors and their effects on muscle growth, in comparison with that in respective positive control groups of castrated guinea pigs, were evaluated with the proposed protocol. © 2005 IEEE. |
Persistent Identifier | http://hdl.handle.net/10722/45725 |
ISSN | 2023 SCImago Journal Rankings: 0.340 |
References |
DC Field | Value | Language |
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dc.contributor.author | Tang, H | en_HK |
dc.contributor.author | Wu, EX | en_HK |
dc.contributor.author | Vasselli, JR | en_HK |
dc.date.accessioned | 2007-10-30T06:33:47Z | - |
dc.date.available | 2007-10-30T06:33:47Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2005, v. 7 VOLS, p. 7044-7047 | en_HK |
dc.identifier.issn | 0589-1019 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/45725 | - |
dc.description.abstract | MRI and image quantitation play an expanding role in modern drug research, because MRI offers high resolution and non-invasive ability, and provides excellent soft tissue contrast. Moreover, with development of effective image segmentation and analysis methods, in-vivo and serial tissue growth measurements could be assessed. In the study, MR image acquisition and analysis protocol were established and validated for investigating the effects of anabolic steroids and precursors on muscle growth and body composition in a guinea pig model. Semi-automatic and interactive segmentation methods were developed to accurately label the tissue of interest for tissue volume estimation. In addition, a longitudinal tissue area outlining procedure was proposed for study of tissue geometric features in relation to tissue growth. Finally, a fully automatic data retrieval and analysis scheme was implemented to facilitate the overall huge amount of image quantitation, statistical analysis, as well as study group comparisons. As a result, highly significant differences in muscle and organ growth were detected between intact and castrated guinea pigs using the selected anabolic steroids, indicating the viability of employing such protocol to assess other anabolic steroids. Furthermore, the anabolic potential of selected steroid precursors and their effects on muscle growth, in comparison with that in respective positive control groups of castrated guinea pigs, were evaluated with the proposed protocol. © 2005 IEEE. | en_HK |
dc.format.extent | 355341 bytes | - |
dc.format.extent | 2851 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | IEEE. | en_HK |
dc.relation.ispartof | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings | en_HK |
dc.rights | ©2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. | - |
dc.subject | Medical sciences | en_HK |
dc.subject | Computer applications | en_HK |
dc.title | MRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=7044&epage=7047&date=2005&atitle=MRI+and+Image+Quantitation+for+Drug+Assessment+-+Growth+Effects+of+Anabolic+Steroids+and+Precursors | en_HK |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wu, EX=rp00193 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1109/IEMBS.2005.1616128 | en_HK |
dc.identifier.scopus | eid_2-s2.0-33846895226 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846895226&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 VOLS | en_HK |
dc.identifier.spage | 7044 | en_HK |
dc.identifier.epage | 7047 | en_HK |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Tang, H=36827331000 | en_HK |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_HK |
dc.identifier.scopusauthorid | Vasselli, JR=7003912429 | en_HK |
dc.identifier.issnl | 0589-1019 | - |