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- Publisher Website: 10.1111/j.1365-2141.2004.05061.x
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- PMID: 15287945
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Article: Tolerance associated with cord blood transplantation may depend on the state of host dentritic cells
Title | Tolerance associated with cord blood transplantation may depend on the state of host dentritic cells |
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Authors | |
Keywords | Cord blood Cytokine Dendritic cell T regulatory cell Tolerance |
Issue Date | 2004 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH |
Citation | British Journal Of Haematology, 2004, v. 126 n. 4, p. 517-526 How to Cite? |
Abstract | Allogeneic cord blood (CB) transplantation is associated with less severe graft-versus-host disease (GvHD), thought to be due to the immaturity of CB T cells, but how T cells interact with host and donor-derived dendritic cells (DCs) to initiate GvHD has not been elucidated. We therefore investigated the responses of CB and adult blood CD4 + T cells co-cultured with adult host DCs of different maturities. Primed by adult host DCs, CB and adult blood CD4 + T cells underwent similar changes in the expression of CD45RA/45RO, CD25, CD40L and CTLA-4. However, CB CD4 + T cells, when primed by either immature or Bacillus Calmette-Guerin mycobacteria-treated adult host DCs, produced lower interferon-γ (IFN-γ) and higher interleukin-10 (IL-10), which is a regulatory T cell-like cytokine profile, as compared with adult blood CD4 + T cells. In contrast, lipopolysaccharide (LPS)-treated adult host DCs significantly up-regulated IFN-γ and down-regulated IL-10 production levels from CB CD4 + T cells to that from adult blood CD4 + T cells. The sustained low IFN-γ and high IL-10 production from CB CD4 + T cells co-cultured with adult blood DCs might account for the less severe GvHD occurrence after CB transplantation, which could be reversed by LPS-treated adult blood DCs. |
Persistent Identifier | http://hdl.handle.net/10722/48652 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.574 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, E | en_HK |
dc.contributor.author | Law, HKW | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2008-05-22T04:20:14Z | - |
dc.date.available | 2008-05-22T04:20:14Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | British Journal Of Haematology, 2004, v. 126 n. 4, p. 517-526 | en_HK |
dc.identifier.issn | 0007-1048 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/48652 | - |
dc.description.abstract | Allogeneic cord blood (CB) transplantation is associated with less severe graft-versus-host disease (GvHD), thought to be due to the immaturity of CB T cells, but how T cells interact with host and donor-derived dendritic cells (DCs) to initiate GvHD has not been elucidated. We therefore investigated the responses of CB and adult blood CD4 + T cells co-cultured with adult host DCs of different maturities. Primed by adult host DCs, CB and adult blood CD4 + T cells underwent similar changes in the expression of CD45RA/45RO, CD25, CD40L and CTLA-4. However, CB CD4 + T cells, when primed by either immature or Bacillus Calmette-Guerin mycobacteria-treated adult host DCs, produced lower interferon-γ (IFN-γ) and higher interleukin-10 (IL-10), which is a regulatory T cell-like cytokine profile, as compared with adult blood CD4 + T cells. In contrast, lipopolysaccharide (LPS)-treated adult host DCs significantly up-regulated IFN-γ and down-regulated IL-10 production levels from CB CD4 + T cells to that from adult blood CD4 + T cells. The sustained low IFN-γ and high IL-10 production from CB CD4 + T cells co-cultured with adult blood DCs might account for the less severe GvHD occurrence after CB transplantation, which could be reversed by LPS-treated adult blood DCs. | en_HK |
dc.format.extent | 151783 bytes | - |
dc.format.extent | 4956 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH | en_HK |
dc.relation.ispartof | British Journal of Haematology | en_HK |
dc.rights | British Journal of Haematology. Copyright © Blackwell Publishing Ltd. | en_HK |
dc.rights | The definitive version is available at www.blackwell-synergy.com | en_HK |
dc.subject | Cord blood | en_HK |
dc.subject | Cytokine | en_HK |
dc.subject | Dendritic cell | en_HK |
dc.subject | T regulatory cell | en_HK |
dc.subject | Tolerance | en_HK |
dc.title | Tolerance associated with cord blood transplantation may depend on the state of host dentritic cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=126&issue=4&spage=517&epage=526&date=2004&atitle=Tolerance+associated+with+cord+blood+transplantation+may+depend+on+the+state+of+host+dendritic+cells | en_HK |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | postprint | en_HK |
dc.identifier.doi | 10.1111/j.1365-2141.2004.05061.x | en_HK |
dc.identifier.pmid | 15287945 | en_HK |
dc.identifier.scopus | eid_2-s2.0-4143088075 | en_HK |
dc.identifier.hkuros | 96427 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4143088075&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 126 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 517 | en_HK |
dc.identifier.epage | 526 | en_HK |
dc.identifier.isi | WOS:000223036300009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Liu, E=7202240063 | en_HK |
dc.identifier.scopusauthorid | Law, HKW=7101939394 | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.issnl | 0007-1048 | - |