File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Comparative genomic hybridization analysis of natural killer cell lymphoma/leukemia: Recognition of consistent patterns of genetic alterations

TitleComparative genomic hybridization analysis of natural killer cell lymphoma/leukemia: Recognition of consistent patterns of genetic alterations
Authors
Issue Date1999
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 1999, v. 155 n. 5, p. 1419-1425 How to Cite?
AbstractPutative natural killer (NK) cell lymphoma/leukemia is a rare group of recently characterized hematolymphoid malignancies. They are highly aggressive and frequently present in extranodal sites, including the nasal area and the upper aerodigestive system, and nonnasal areas such as the skin and the gastrointestinal tract. According to clinicopathological features, they can be classified into nasal NK cell lymphoma, nasal-type NK cell lymphoma occurring in nonnasal areas, and NK cell lymphoma/leukemia. Genetic alterations in NK cell lymphoma/leukemia are not well defined. In this study, we have performed comparative genomic hybridization (CGH) on DNA extracted from fresh or frozen tissues of 10 patients with NK cell lymphoma/leukemia. They comprised four nasal NK cell lymphomas, one nasal-type NK cell lymphoma, and five NK cell lymphomas/leukemias. CGH showed frequent deletions at 6q16- q27 (four cases), 13q14-q34 (three cases), 11q22-q25 (two cases), 17p13 (two cases), and loss of the whole chromosome X (two cases). DNA amplification was observed in a majority of the chromosomes. Five cases showed DNA gains at region 1p32-pter. Frequent DNA gains were also found in chromosomes 6p, 11q, 12q, 17q, 19p, 20q, and Xp (three cases each). Interestingly, DNA gains were more frequent in nasal/nasal-type NK cell lymphomas than NK cell lymphoma/leukemia. These genetic alterations correlated well with karyotypic features found in some of the cases. The frequent DNA losses at 6q and 13q suggest that the presence of tumor suppressor genes at these regions is important in NK cell transformation. In addition to establishing novel patterns of genomic imbalances in these rare NK cell malignancies, which may be targets for future molecular analysis, this study also provides important information on genetic alterations in NK cell lymphomas that may be useful in defining their positions in current lymphoma classification schemes, which are increasingly focusing on phenotypic and genotypic correlations.
Persistent Identifierhttp://hdl.handle.net/10722/49103
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 1.647
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, LLPen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, JKCen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2008-06-12T06:34:29Z-
dc.date.available2008-06-12T06:34:29Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Pathology, 1999, v. 155 n. 5, p. 1419-1425en_HK
dc.identifier.issn0002-9440en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49103-
dc.description.abstractPutative natural killer (NK) cell lymphoma/leukemia is a rare group of recently characterized hematolymphoid malignancies. They are highly aggressive and frequently present in extranodal sites, including the nasal area and the upper aerodigestive system, and nonnasal areas such as the skin and the gastrointestinal tract. According to clinicopathological features, they can be classified into nasal NK cell lymphoma, nasal-type NK cell lymphoma occurring in nonnasal areas, and NK cell lymphoma/leukemia. Genetic alterations in NK cell lymphoma/leukemia are not well defined. In this study, we have performed comparative genomic hybridization (CGH) on DNA extracted from fresh or frozen tissues of 10 patients with NK cell lymphoma/leukemia. They comprised four nasal NK cell lymphomas, one nasal-type NK cell lymphoma, and five NK cell lymphomas/leukemias. CGH showed frequent deletions at 6q16- q27 (four cases), 13q14-q34 (three cases), 11q22-q25 (two cases), 17p13 (two cases), and loss of the whole chromosome X (two cases). DNA amplification was observed in a majority of the chromosomes. Five cases showed DNA gains at region 1p32-pter. Frequent DNA gains were also found in chromosomes 6p, 11q, 12q, 17q, 19p, 20q, and Xp (three cases each). Interestingly, DNA gains were more frequent in nasal/nasal-type NK cell lymphomas than NK cell lymphoma/leukemia. These genetic alterations correlated well with karyotypic features found in some of the cases. The frequent DNA losses at 6q and 13q suggest that the presence of tumor suppressor genes at these regions is important in NK cell transformation. In addition to establishing novel patterns of genomic imbalances in these rare NK cell malignancies, which may be targets for future molecular analysis, this study also provides important information on genetic alterations in NK cell lymphomas that may be useful in defining their positions in current lymphoma classification schemes, which are increasingly focusing on phenotypic and genotypic correlations.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_HK
dc.relation.ispartofAmerican Journal of Pathologyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshKiller Cells, Natural - pathologyen_HK
dc.subject.meshLeukemia, T-Cell - genetics - pathologyen_HK
dc.subject.meshLymphoma, T-Cell - genetics - pathologyen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.titleComparative genomic hybridization analysis of natural killer cell lymphoma/leukemia: Recognition of consistent patterns of genetic alterationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9440&volume=155&issue=5&spage=1419&epage=1425&date=1999&atitle=Comparative+genomic+hybridization+analysis+of+natural+killer+cell+lymphoma/leukemia:+recognition+of+consistent+patterns+of+genetic+alterationsen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1016/S0002-9440(10)65454-5-
dc.identifier.pmid10550295-
dc.identifier.pmcidPMC1866965en_HK
dc.identifier.scopuseid_2-s2.0-0032733015en_HK
dc.identifier.hkuros49579-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032733015&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume155en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1419en_HK
dc.identifier.epage1425en_HK
dc.identifier.isiWOS:000083587600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, LLP=35574705900en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, JKC=26430517500en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0002-9440-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats