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Article: A Newly Discovered Verotoxin Variant, VT2g, Produced by Bovine Verocytotoxigenic Escherichia coli

TitleA Newly Discovered Verotoxin Variant, VT2g, Produced by Bovine Verocytotoxigenic Escherichia coli
Authors
Leung, PHMPeiris, JSMNg, WWSRobins-Browne, RMBettelheim, KAYam, WC
Issue Date2003
PublisherAmerican Society for Microbiology.
Citation
Applied and Environmental Microbiology, 2003, v. 69 n. 12, p. 7549-7553 How to Cite?
DOI: http://dx.doi.org/10.1128/AEM.69.12.7549-7553.2003
AbstractA new verotoxin (VT) variant, designated vt2g, was identified from a bovine strain of verocytotoxigenic Escherichia coli (VTEC) serotype O2:H25. When vt2g was aligned with published sequences of vt2 and vt variants, it exhibited the highest DNA sequence homology with vt2 and vt2c. However, vt2g was not detected by vt2-specific primers and probes, although it was partially neutralized by an antiserum to the VT2A subunit. VT2g was cytotoxic for Vero and HeLa cells and was not activated by mouse intestinal mucus. The vt2g gene was detected in 3 of 409 (0.7%) bovine VTEC strains, including serotypes O2:H25, O2:H45 and Ont:H -.
Persistent Identifierhttp://hdl.handle.net/10722/49240
ISSN
0099-2240
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.016
PubMed Central ID
PMC309948
ISI Accession Number ID
WOS:000187234000077
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLeung, PHMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorNg, WWSen_HK
dc.contributor.authorRobins-Browne, RMen_HK
dc.contributor.authorBettelheim, KAen_HK
dc.contributor.authorYam, WCen_HK
dc.date.accessioned2008-06-12T06:37:24Z-
dc.date.available2008-06-12T06:37:24Z-
dc.date.issued2003en_HK
dc.identifier.citationApplied and Environmental Microbiology, 2003, v. 69 n. 12, p. 7549-7553en_HK
dc.identifier.issn0099-2240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49240-
dc.description.abstractA new verotoxin (VT) variant, designated vt2g, was identified from a bovine strain of verocytotoxigenic Escherichia coli (VTEC) serotype O2:H25. When vt2g was aligned with published sequences of vt2 and vt variants, it exhibited the highest DNA sequence homology with vt2 and vt2c. However, vt2g was not detected by vt2-specific primers and probes, although it was partially neutralized by an antiserum to the VT2A subunit. VT2g was cytotoxic for Vero and HeLa cells and was not activated by mouse intestinal mucus. The vt2g gene was detected in 3 of 409 (0.7%) bovine VTEC strains, including serotypes O2:H25, O2:H45 and Ont:H -.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofApplied and Environmental Microbiologyen_HK
dc.subject.meshCattle Diseases - microbiologyen_HK
dc.subject.meshEscherichia coli - metabolism - pathogenicityen_HK
dc.subject.meshEscherichia coli Infections - microbiology - veterinaryen_HK
dc.subject.meshShiga Toxin 2 - chemistry - genetics - metabolism - toxicityen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.titleA Newly Discovered Verotoxin Variant, VT2g, Produced by Bovine Verocytotoxigenic Escherichia colien_HK
dc.typeArticleen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1128/AEM.69.12.7549-7553.2003en_HK
dc.identifier.pmid14660413en_HK
dc.identifier.pmcidPMC309948en_HK
dc.identifier.scopuseid_2-s2.0-2142743315en_HK
dc.identifier.hkuros87610-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2142743315&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue12en_HK
dc.identifier.spage7549en_HK
dc.identifier.epage7553en_HK
dc.identifier.isiWOS:000187234000077-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, PHM=7401747852en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridNg, WWS=36787042600en_HK
dc.identifier.scopusauthoridRobinsBrowne, RM=7006901869en_HK
dc.identifier.scopusauthoridBettelheim, KA=7004458313en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.issnl0099-2240-

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