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- Publisher Website: 10.1523/JNEUROSCI.21-18-07063.2001
- Scopus: eid_2-s2.0-0035884769
- PMID: 11549716
- WOS: WOS:000170922800010
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Article: Secretin facilitates GABA transmission in the cerebellum
Title | Secretin facilitates GABA transmission in the cerebellum |
---|---|
Authors | |
Keywords | Autism Cerebellum GABA Inhibitory postsynaptic currents Purkinje cells Secretin |
Issue Date | 2001 |
Publisher | Society for Neuroscience. The Journal's web site is located at http://www.jneurosci.org |
Citation | Journal Of Neuroscience, 2001, v. 21 n. 18, p. 7063-7068 How to Cite? |
Abstract | Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity. |
Persistent Identifier | http://hdl.handle.net/10722/53487 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 2.321 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yung, WH | en_HK |
dc.contributor.author | Leung, PS | en_HK |
dc.contributor.author | Ng, SSM | en_HK |
dc.contributor.author | Zhang, J | en_HK |
dc.contributor.author | Chan, SCY | en_HK |
dc.contributor.author | Chow, BKC | en_HK |
dc.date.accessioned | 2009-04-03T07:21:14Z | - |
dc.date.available | 2009-04-03T07:21:14Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Journal Of Neuroscience, 2001, v. 21 n. 18, p. 7063-7068 | en_HK |
dc.identifier.issn | 0270-6474 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/53487 | - |
dc.description.abstract | Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Society for Neuroscience. The Journal's web site is located at http://www.jneurosci.org | en_HK |
dc.relation.ispartof | Journal of Neuroscience | en_HK |
dc.rights | Journal of Neuroscience. Copyright © Society for Neuroscience. | en_HK |
dc.subject | Autism | en_HK |
dc.subject | Cerebellum | en_HK |
dc.subject | GABA | en_HK |
dc.subject | Inhibitory postsynaptic currents | en_HK |
dc.subject | Purkinje cells | en_HK |
dc.subject | Secretin | en_HK |
dc.title | Secretin facilitates GABA transmission in the cerebellum | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-6474&volume=21&issue=8&spage=7063&epage=7068&date=2001&atitle=Secretin+facilitates+GABA+transmission+in+the+cerebellum | en_HK |
dc.identifier.email | Ng, SSM: ssmng@hku.hk | en_HK |
dc.identifier.email | Chow, BKC: bkcc@hku.hk | en_HK |
dc.identifier.authority | Ng, SSM=rp00767 | en_HK |
dc.identifier.authority | Chow, BKC=rp00681 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1523/JNEUROSCI.21-18-07063.2001 | - |
dc.identifier.pmid | 11549716 | - |
dc.identifier.scopus | eid_2-s2.0-0035884769 | en_HK |
dc.identifier.hkuros | 65786 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035884769&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 21 | en_HK |
dc.identifier.issue | 18 | en_HK |
dc.identifier.spage | 7063 | en_HK |
dc.identifier.epage | 7068 | en_HK |
dc.identifier.isi | WOS:000170922800010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yung, WH=7103137893 | en_HK |
dc.identifier.scopusauthorid | Leung, PS=7401748938 | en_HK |
dc.identifier.scopusauthorid | Ng, SSM=7403358718 | en_HK |
dc.identifier.scopusauthorid | Zhang, J=7601342104 | en_HK |
dc.identifier.scopusauthorid | Chan, SCY=25930246600 | en_HK |
dc.identifier.scopusauthorid | Chow, BKC=7102826193 | en_HK |
dc.identifier.issnl | 0270-6474 | - |