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Article: Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

TitleLack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia
Authors
Chui, CHLeung, PHMLau, FYWan, TSKChan, LCCheng, G
KeywordsBlotting, Southern
Leukemia, myelocytic, acute
Myelodysplastic syndromes
Proto-oncogene proteins c-kit/genetics
Stem cell factor
Issue Date1998
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
Hong Kong Medical Journal, 1998, v. 4 n. 1, p. 27-30 How to Cite?
AbstractStem cell factor is a haemopoietic growth factor that interacts with the c-kit--encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.
Persistent Identifierhttp://hdl.handle.net/10722/54194
ISSN
1024-2708
2021 Impact Factor: 1.256
2020 SCImago Journal Rankings: 0.357

 

DC FieldValueLanguage
dc.contributor.authorChui, CHen_HK
dc.contributor.authorLeung, PHMen_HK
dc.contributor.authorLau, FYen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorCheng, Gen_HK
dc.date.accessioned2009-04-03T07:39:14Z-
dc.date.available2009-04-03T07:39:14Z-
dc.date.issued1998en_HK
dc.identifier.citationHong Kong Medical Journal, 1998, v. 4 n. 1, p. 27-30en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54194-
dc.description.abstractStem cell factor is a haemopoietic growth factor that interacts with the c-kit--encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.orgen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.subjectBlotting, Southernen_HK
dc.subjectLeukemia, myelocytic, acuteen_HK
dc.subjectMyelodysplastic syndromesen_HK
dc.subjectProto-oncogene proteins c-kit/geneticsen_HK
dc.subjectStem cell factoren_HK
dc.titleLack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=4&issue=1&spage=27&epage=30&date=1998&atitle=Lack+of+structural+rearrangement+in+c-kit+and+stem+cell+factor+genes+in+Hong+Kong+Chinese+patients+with+myelodysplastic+syndromes+or+acute+myeloid+leukaemiaen_HK
dc.identifier.emailChan, LC: chanlc@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11832549en_HK
dc.identifier.hkuros33679-
dc.identifier.issnl1024-2708-

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