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Article: Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

TitleAssociation of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians
Authors
Song, YQCheung, KMCHo, DWHPoon, SCSChiba, KKawaguchi, YHirose, YAlini, MGrad, SYee, AFYLeong, JohnCYLuk, KDKYip, SPKarppinen, JCheah, KSESham, PIkegawa, SChan, D
Issue Date2008
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal of Human Genetics, 2008, v. 82 n. 3, p. 744-747 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ajhg.2007.12.017
AbstractLumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD. © 2008 The American Society of Human Genetics.
Persistent Identifierhttp://hdl.handle.net/10722/57175
ISSN
0002-9297
2023 Impact Factor: 8.1
2023 SCImago Journal Rankings: 4.516
PubMed Central ID
PMC2427233
ISI Accession Number ID
WOS:000254067800018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSong, YQen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorHo, DWHen_HK
dc.contributor.authorPoon, SCSen_HK
dc.contributor.authorChiba, Ken_HK
dc.contributor.authorKawaguchi, Yen_HK
dc.contributor.authorHirose, Yen_HK
dc.contributor.authorAlini, Men_HK
dc.contributor.authorGrad, Sen_HK
dc.contributor.authorYee, AFYen_HK
dc.contributor.authorLeong, JohnCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorKarppinen, Jen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorIkegawa, Sen_HK
dc.contributor.authorChan, Den_HK
dc.date.accessioned2010-04-12T01:28:19Z-
dc.date.available2010-04-12T01:28:19Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal of Human Genetics, 2008, v. 82 n. 3, p. 744-747en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57175-
dc.description.abstractLumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD. © 2008 The American Society of Human Genetics.en_HK
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshExtracellular Matrix Proteins - chemistry - geneticsen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshIntervertebral Disken_HK
dc.subject.meshLumbar Vertebraeen_HK
dc.titleAssociation of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asiansen_HK
dc.typeArticleen_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1016/j.ajhg.2007.12.017en_HK
dc.identifier.pmid18304494en_HK
dc.identifier.pmcidPMC2427233en_HK
dc.identifier.scopuseid_2-s2.0-41149171224en_HK
dc.identifier.hkuros145963-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41149171224&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue3en_HK
dc.identifier.spage744en_HK
dc.identifier.epage747en_HK
dc.identifier.eissn1537-6605-
dc.identifier.isiWOS:000254067800018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridHo, DWH=23502006100en_HK
dc.identifier.scopusauthoridPoon, SCS=23502238200en_HK
dc.identifier.scopusauthoridChiba, K=7201563603en_HK
dc.identifier.scopusauthoridKawaguchi, Y=7401964621en_HK
dc.identifier.scopusauthoridHirose, Y=36928480700en_HK
dc.identifier.scopusauthoridAlini, M=7003375963en_HK
dc.identifier.scopusauthoridGrad, S=6603427892en_HK
dc.identifier.scopusauthoridYee, AFY=23494406200en_HK
dc.identifier.scopusauthoridLeong, JohnCY=24329593400en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridKarppinen, J=7004560479en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridIkegawa, S=7102780383en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.issnl0002-9297-

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