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Article: Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats

TitleMotor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats
Authors
Chu, THDu, YWu, W
KeywordsAvulsion
BDNF
GDNF
Motoneuron regeneration
Peripheral nerve implantation
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 2008, v. 212 n. 2, p. 562-565 How to Cite?
DOI: http://dx.doi.org/10.1016/j.expneurol.2008.05.001
AbstractIn the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-implanted group. We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord. This may account for the superiority of motor over sensory nerve in promoting motor axon regeneration and motoneuron survival. Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58238
ISSN
0014-4886
2021 Impact Factor: 5.620
2020 SCImago Journal Rankings: 1.779
ISI Accession Number ID
WOS:000258252000042
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChu, THen_HK
dc.contributor.authorDu, Yen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-05-31T03:26:24Z-
dc.date.available2010-05-31T03:26:24Z-
dc.date.issued2008en_HK
dc.identifier.citationExperimental Neurology, 2008, v. 212 n. 2, p. 562-565en_HK
dc.identifier.issn0014-4886en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58238-
dc.description.abstractIn the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-implanted group. We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord. This may account for the superiority of motor over sensory nerve in promoting motor axon regeneration and motoneuron survival. Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_HK
dc.relation.ispartofExperimental Neurologyen_HK
dc.subjectAvulsion-
dc.subjectBDNF-
dc.subjectGDNF-
dc.subjectMotoneuron regeneration-
dc.subjectPeripheral nerve implantation-
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain-Derived Neurotrophic Factor - genetics - metabolismen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factor - genetics - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMotor Neurons - physiologyen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.subject.meshNeurons, Afferent - physiologyen_HK
dc.subject.meshPeripheral Nerves - cytology - transplantationen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRadiculopathy - pathology - surgeryen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleMotor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-4886&volume=212&spage=562&epage=565&date=2008&atitle=Motor+nerve+graft+is+better+than+sensory+nerve+graft+for+survival+and+regeneration+of+motoneurons+after+spinal+root+avulsion+in+adult+rats.en_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.expneurol.2008.05.001en_HK
dc.identifier.pmid18555993-
dc.identifier.scopuseid_2-s2.0-47349099688en_HK
dc.identifier.hkuros154236en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47349099688&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume212en_HK
dc.identifier.issue2en_HK
dc.identifier.spage562en_HK
dc.identifier.epage565en_HK
dc.identifier.isiWOS:000258252000042-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, TH=14023966500en_HK
dc.identifier.scopusauthoridDu, Y=36993717500en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.issnl0014-4886-

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