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Article: ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
Title | ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai | ||||
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Authors | |||||
Issue Date | 2009 | ||||
Publisher | Oxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/ | ||||
Citation | Human Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 How to Cite? | ||||
Abstract | ITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s). | ||||
Persistent Identifier | http://hdl.handle.net/10722/59181 | ||||
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.602 | ||||
PubMed Central ID | |||||
ISI Accession Number ID |
Funding Information: This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, W | en_HK |
dc.contributor.author | Zhao, M | en_HK |
dc.contributor.author | Hirankarn, N | en_HK |
dc.contributor.author | Lau, CS | en_HK |
dc.contributor.author | Mok, CC | en_HK |
dc.contributor.author | Chan, TM | en_HK |
dc.contributor.author | Wong, RWS | en_HK |
dc.contributor.author | Lee, KW | en_HK |
dc.contributor.author | Mok, MY | en_HK |
dc.contributor.author | Wong, SN | en_HK |
dc.contributor.author | Avihingsanon, Y | en_HK |
dc.contributor.author | Oi Lin, ING | en_HK |
dc.contributor.author | Lee, TL | en_HK |
dc.contributor.author | Ho, MHK | en_HK |
dc.contributor.author | Lee, PPW | en_HK |
dc.contributor.author | Wong, WHS | en_HK |
dc.contributor.author | Sham, PC | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2010-05-31T03:44:28Z | - |
dc.date.available | 2010-05-31T03:44:28Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Human Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 | en_HK |
dc.identifier.issn | 0964-6906 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59181 | - |
dc.description.abstract | ITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s). | en_HK |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Human Molecular Genetics | en_HK |
dc.rights | Human Molecular Genetics. Copyright © Oxford University Press. | en_HK |
dc.subject.mesh | Antigens, CD11b - genetics | - |
dc.subject.mesh | Asian Continental Ancestry Group - ethnology - genetics | - |
dc.subject.mesh | Disease Susceptibility | - |
dc.subject.mesh | Lupus Erythematosus, Systemic - ethnology - genetics | - |
dc.subject.mesh | Nephritis - ethnology - genetics | - |
dc.title | ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0964-6906&volume=18&issue=11&spage=2063&epage=2070&date=2009&atitle=ITGAM+is+associated+with+disease+susceptibility+and+renal+nephritis+of+systemic+lupus+erythematosus+in+Hong+Kong+Chinese+and+Thai | en_HK |
dc.identifier.email | Yang, W: yangwl@hkucc.hku.hk | en_HK |
dc.identifier.email | Lau, CS: cslau@hku.hk | en_HK |
dc.identifier.email | Chan, TM: dtmchan@hku.hk | en_HK |
dc.identifier.email | Mok, MY: temy@hkucc.hku.hk | en_HK |
dc.identifier.email | Lee, PPW: ppwlee@hku.hk | en_HK |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_HK |
dc.identifier.email | Lau, YL: lauylung@hku.hk | en_HK |
dc.identifier.authority | Yang, W=rp00524 | en_HK |
dc.identifier.authority | Lau, CS=rp01348 | en_HK |
dc.identifier.authority | Chan, TM=rp00394 | en_HK |
dc.identifier.authority | Mok, MY=rp00490 | en_HK |
dc.identifier.authority | Lee, PPW=rp00462 | en_HK |
dc.identifier.authority | Sham, PC=rp00459 | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1093/hmg/ddp118 | en_HK |
dc.identifier.pmid | 19286673 | - |
dc.identifier.pmcid | PMC2678927 | - |
dc.identifier.scopus | eid_2-s2.0-65549161855 | en_HK |
dc.identifier.hkuros | 161355 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-65549161855&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 18 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 2063 | en_HK |
dc.identifier.epage | 2070 | en_HK |
dc.identifier.eissn | 1460-2083 | - |
dc.identifier.isi | WOS:000265951600015 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Yang, W=23101349500 | en_HK |
dc.identifier.scopusauthorid | Zhao, M=13309644600 | en_HK |
dc.identifier.scopusauthorid | Hirankarn, N=12783320200 | en_HK |
dc.identifier.scopusauthorid | Lau, CS=14035682100 | en_HK |
dc.identifier.scopusauthorid | Mok, CC=34668219600 | en_HK |
dc.identifier.scopusauthorid | Chan, TM=7402687700 | en_HK |
dc.identifier.scopusauthorid | Wong, RWS=34875928200 | en_HK |
dc.identifier.scopusauthorid | Lee, KW=35788977700 | en_HK |
dc.identifier.scopusauthorid | Mok, MY=7006024184 | en_HK |
dc.identifier.scopusauthorid | Wong, SN=7404590305 | en_HK |
dc.identifier.scopusauthorid | Avihingsanon, Y=6506712307 | en_HK |
dc.identifier.scopusauthorid | Oi Lin, ING=26536375500 | en_HK |
dc.identifier.scopusauthorid | Lee, TL=8508917400 | en_HK |
dc.identifier.scopusauthorid | Ho, MHK=8925896400 | en_HK |
dc.identifier.scopusauthorid | Lee, PPW=14048822200 | en_HK |
dc.identifier.scopusauthorid | Wong, WHS=13310222200 | en_HK |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.issnl | 0964-6906 | - |