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- Publisher Website: 10.1111/j.1540-8167.2009.01547.x
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- PMID: 19602020
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Article: Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation
Title | Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation | ||||
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Authors | |||||
Keywords | Atrial contraction velocity Inter- or intraatrial synchronicity Paroxysmal atrial fibrillation Sinus node disease Tissue Doppler imaging | ||||
Issue Date | 2009 | ||||
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873 | ||||
Citation | Journal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 11, p. 1237-1243 How to Cite? | ||||
Abstract | Atrial Mechanical Dyssynchrony in Sinus Node Disease.Introduction: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. Methods: We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual-chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septallateralinferioranteriorposterioranterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. Results: There were no differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 ± 19 vs 91 ± 17 cms, P = 0.005), LA active empting fraction (24 ± 14 vs 36 ± 13%, P = 0.027), mean Va of LA (2.6 ± 0.9 vs 3.4 ± 0.9 cms, P = 0.028), and greater interatrial synchronicity (33 ± 25 vs 12 ± 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR] = 1.12, 95% Confidence interval [CI] 1.01-1.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01-1.16, P = 0.020) were independent predictors for the presence of AF in SND patients. Conclusion: SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients. © 2009 Wiley Periodicals, Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/59191 | ||||
ISSN | 2021 Impact Factor: 2.942 2020 SCImago Journal Rankings: 1.193 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by General Research Fund of Research Grant Council of Hong Kong (HKU 7777/07M and HKU 7775/08M). | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, M | en_HK |
dc.contributor.author | Lau, CP | en_HK |
dc.contributor.author | Zhang, XH | en_HK |
dc.contributor.author | Siu, CW | en_HK |
dc.contributor.author | Lee, KLF | en_HK |
dc.contributor.author | Yan, GH | en_HK |
dc.contributor.author | Yue, WS | en_HK |
dc.contributor.author | Tse, HF | en_HK |
dc.date.accessioned | 2010-05-31T03:44:44Z | - |
dc.date.available | 2010-05-31T03:44:44Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Journal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 11, p. 1237-1243 | en_HK |
dc.identifier.issn | 1045-3873 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59191 | - |
dc.description.abstract | Atrial Mechanical Dyssynchrony in Sinus Node Disease.Introduction: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. Methods: We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual-chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septallateralinferioranteriorposterioranterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. Results: There were no differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 ± 19 vs 91 ± 17 cms, P = 0.005), LA active empting fraction (24 ± 14 vs 36 ± 13%, P = 0.027), mean Va of LA (2.6 ± 0.9 vs 3.4 ± 0.9 cms, P = 0.028), and greater interatrial synchronicity (33 ± 25 vs 12 ± 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR] = 1.12, 95% Confidence interval [CI] 1.01-1.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01-1.16, P = 0.020) were independent predictors for the presence of AF in SND patients. Conclusion: SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients. © 2009 Wiley Periodicals, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873 | en_HK |
dc.relation.ispartof | Journal of Cardiovascular Electrophysiology | en_HK |
dc.rights | The definitive version is available at www3.interscience.wiley.com | - |
dc.subject | Atrial contraction velocity | en_HK |
dc.subject | Inter- or intraatrial synchronicity | en_HK |
dc.subject | Paroxysmal atrial fibrillation | en_HK |
dc.subject | Sinus node disease | en_HK |
dc.subject | Tissue Doppler imaging | en_HK |
dc.subject.mesh | Aged | - |
dc.subject.mesh | Arrhythmia, Sinus - diagnosis - epidemiology | - |
dc.subject.mesh | Atrial Fibrillation - diagnosis - epidemiology | - |
dc.subject.mesh | Hong Kong - epidemiology | - |
dc.subject.mesh | Ventricular Dysfunction, Left - diagnosis - epidemiology | - |
dc.title | Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-3873&volume=20&issue=11&spage=1237–1243&epage=&date=2009&atitle=Interatrial+mechanical+dyssynchrony+worsened+atrial+mechanical+function+in+sinus+node+disease+with+or+without+paroxysmal+atrial+fibrillation | en_HK |
dc.identifier.email | Wang, M:meiwang@hkucc.hku.hk | en_HK |
dc.identifier.email | Siu, CW:cwdsiu@hkucc.hku.hk | en_HK |
dc.identifier.email | Tse, HF:hftse@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wang, M=rp00281 | en_HK |
dc.identifier.authority | Siu, CW=rp00534 | en_HK |
dc.identifier.authority | Tse, HF=rp00428 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1540-8167.2009.01547.x | en_HK |
dc.identifier.pmid | 19602020 | - |
dc.identifier.scopus | eid_2-s2.0-70350616528 | en_HK |
dc.identifier.hkuros | 155823 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70350616528&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 1237 | en_HK |
dc.identifier.epage | 1243 | en_HK |
dc.identifier.isi | WOS:000271416700009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wang, M=7406690398 | en_HK |
dc.identifier.scopusauthorid | Lau, CP=35275317200 | en_HK |
dc.identifier.scopusauthorid | Zhang, XH=16425051500 | en_HK |
dc.identifier.scopusauthorid | Siu, CW=7006550690 | en_HK |
dc.identifier.scopusauthorid | Lee, KLF=8624893900 | en_HK |
dc.identifier.scopusauthorid | Yan, GH=36544693600 | en_HK |
dc.identifier.scopusauthorid | Yue, WS=36106565300 | en_HK |
dc.identifier.scopusauthorid | Tse, HF=7006070805 | en_HK |
dc.identifier.citeulike | 6177469 | - |
dc.identifier.issnl | 1045-3873 | - |