File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema

TitleInvolvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema
Authors
KeywordsCFTR
Chlamydia trachomatis
Cytokines
Edema
Infection
Issue Date2008
PublisherPortland Press Ltd.. The Journal's web site is located at http://www.cellbiolint.org/cbi/default.htm
Citation
Cell Biology International, 2008, v. 32 n. 7, p. 801-806 How to Cite?
AbstractAbnormal fluid accumulation in tissues, including the life-threatening cerebral and pulmonary edema, is a severe consequence of bacteria infection. Chlamydia (C.) trachomatis is an obligate intracellular gram-negative human pathogen responsible for a spectrum of diseases, causing tissue fluid accumulation and edema in various organs. However, the underlying mechanism for tissue fluid secretion induced by C. trachomatis and most of other infectious pathogens is not known. Here, we report that in mice C. trachomatis infection models, the expression of cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel, is up regulated together with increased cytokine release and tissue fluid accumulation that can be reversed by treatment with antibiotic specific for C. trachomatis and CFTR channel blocker. However, C. trachomatis infection cannot induce tissue edema in CFTR tm1Unc mutant mice. Administration of exogenous IL-1β to mice mimics the C. trachomatis infection-induced CFTR upregulation, enhanced CFTR channel activity and fluid accumulation, further confirming the involvement of CFTR in infection-induced tissue fluid secretion. © 2008 International Federation for Cell Biology.
Persistent Identifierhttp://hdl.handle.net/10722/60384
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.847
ISI Accession Number ID
Funding AgencyGrant Number
LKS Institute of Health Sciences
Strategic Investment of the Chinese University of Hong Kong, Shatin
Funding Information:

The work was supported by LKS Institute of Health Sciences and the Strategic Investment of the Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. The authors do not have a commercial or other association that might pose a conflict of interest.

References

 

DC FieldValueLanguage
dc.contributor.authorAjonuma, LCen_HK
dc.contributor.authorHe, Qen_HK
dc.contributor.authorSheung Chan, PKen_HK
dc.contributor.authorYu Ng, EHen_HK
dc.contributor.authorFok, KLen_HK
dc.contributor.authorYan Wong, CHen_HK
dc.contributor.authorTsang, LLen_HK
dc.contributor.authorHo, LSen_HK
dc.contributor.authorLau, MCen_HK
dc.contributor.authorHuang, HYen_HK
dc.contributor.authorYang, DZen_HK
dc.contributor.authorRowlands, DKen_HK
dc.contributor.authorTang, XXen_HK
dc.contributor.authorZhang, XHen_HK
dc.contributor.authorChung, YWen_HK
dc.contributor.authorChan, HCen_HK
dc.date.accessioned2010-05-31T04:09:34Z-
dc.date.available2010-05-31T04:09:34Z-
dc.date.issued2008en_HK
dc.identifier.citationCell Biology International, 2008, v. 32 n. 7, p. 801-806en_HK
dc.identifier.issn1065-6995en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60384-
dc.description.abstractAbnormal fluid accumulation in tissues, including the life-threatening cerebral and pulmonary edema, is a severe consequence of bacteria infection. Chlamydia (C.) trachomatis is an obligate intracellular gram-negative human pathogen responsible for a spectrum of diseases, causing tissue fluid accumulation and edema in various organs. However, the underlying mechanism for tissue fluid secretion induced by C. trachomatis and most of other infectious pathogens is not known. Here, we report that in mice C. trachomatis infection models, the expression of cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel, is up regulated together with increased cytokine release and tissue fluid accumulation that can be reversed by treatment with antibiotic specific for C. trachomatis and CFTR channel blocker. However, C. trachomatis infection cannot induce tissue edema in CFTR tm1Unc mutant mice. Administration of exogenous IL-1β to mice mimics the C. trachomatis infection-induced CFTR upregulation, enhanced CFTR channel activity and fluid accumulation, further confirming the involvement of CFTR in infection-induced tissue fluid secretion. © 2008 International Federation for Cell Biology.en_HK
dc.languageengen_HK
dc.publisherPortland Press Ltd.. The Journal's web site is located at http://www.cellbiolint.org/cbi/default.htmen_HK
dc.relation.ispartofCell Biology Internationalen_HK
dc.subjectCFTRen_HK
dc.subjectChlamydia trachomatisen_HK
dc.subjectCytokinesen_HK
dc.subjectEdemaen_HK
dc.subjectInfectionen_HK
dc.titleInvolvement of cystic fibrosis transmembrane conductance regulator in infection-induced edemaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1065-6995&volume=32&spage=801&epage=806&date=2008&atitle=Involvement+of+cystic+fibrosis+transmembrane+conductance+regulator+in+infection-induced+edemaen_HK
dc.identifier.emailAjonuma, LC: louisca@hkucc.hku.hken_HK
dc.identifier.emailYu Ng, EH: nghye@hku.hken_HK
dc.identifier.authorityAjonuma, LC=rp00051en_HK
dc.identifier.authorityYu Ng, EH=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cellbi.2008.03.010en_HK
dc.identifier.pmid18462959-
dc.identifier.scopuseid_2-s2.0-44449151611en_HK
dc.identifier.hkuros156807en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44449151611&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue7en_HK
dc.identifier.spage801en_HK
dc.identifier.epage806en_HK
dc.identifier.isiWOS:000260671400012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAjonuma, LC=6602292557en_HK
dc.identifier.scopusauthoridHe, Q=36652577800en_HK
dc.identifier.scopusauthoridSheung Chan, PK=24169750300en_HK
dc.identifier.scopusauthoridYu Ng, EH=35238184300en_HK
dc.identifier.scopusauthoridFok, KL=15030063000en_HK
dc.identifier.scopusauthoridYan Wong, CH=24170376500en_HK
dc.identifier.scopusauthoridTsang, LL=7103290955en_HK
dc.identifier.scopusauthoridHo, LS=7402955607en_HK
dc.identifier.scopusauthoridLau, MC=24169129500en_HK
dc.identifier.scopusauthoridHuang, HY=37025365800en_HK
dc.identifier.scopusauthoridYang, DZ=14319464000en_HK
dc.identifier.scopusauthoridRowlands, DK=7103109123en_HK
dc.identifier.scopusauthoridTang, XX=24169711800en_HK
dc.identifier.scopusauthoridZhang, XH=7410282957en_HK
dc.identifier.scopusauthoridChung, YW=7404388001en_HK
dc.identifier.scopusauthoridChan, HC=7403402737en_HK
dc.identifier.issnl1065-6995-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats