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Conference Paper: Single nucleotide polymorphisms of complement component 5 and periodontitis

TitleSingle nucleotide polymorphisms of complement component 5 and periodontitis
Authors
Chai, LSong, YQZee, KYLeung, WK
KeywordsComplement C5
Periodontitis
Polymorphism, genetic
Smoking
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0303-6979
Citation
Europerio 6, Stockholm, Sweden, 4-6 June 2009. In Journal of Clinical Periodontology, 2009, v. 36 suppl. 9, p. 87, abstracts no. 176 How to Cite?
AbstractPolymorphisms of host defense genes might increase ones risks for periodontitis. This study investigated single nucleotide polymorphisms (SNPs) in the coding and regulatory regions of the innate host defense element complement component 5 (C5) in association with periodontitis. 229 periodontitis patients and 207 periodontitis-free subjects were recruited for genotyping 11 tagging SNPs. AG of rs17611 was more prevalent in periodontitis patient group (P = 0.023). The haplotype CGCA of block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis (P = 0.038). Rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was significantly associated with periodontitis (P = 0.004). In conclusion, the tagging SNP rs17611 of C5, together with smoking appeared to be associated with periodontitis.
DescriptionThis free journal suppl. entitled: Special Issue: Abstracts of Europerio 6, 4-6 June 2009, Stockholm, Sweden
Poster Abstracts: abstract no. 176 (Ref no: EUABS065655)
Persistent Identifierhttp://hdl.handle.net/10722/61359
ISSN
0303-6979
2021 Impact Factor: 7.478
2020 SCImago Journal Rankings: 3.456

 

DC FieldValueLanguage
dc.contributor.authorChai, Len_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorZee, KYen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2010-07-13T03:37:57Z-
dc.date.available2010-07-13T03:37:57Z-
dc.date.issued2009en_HK
dc.identifier.citationEuroperio 6, Stockholm, Sweden, 4-6 June 2009. In Journal of Clinical Periodontology, 2009, v. 36 suppl. 9, p. 87, abstracts no. 176en_HK
dc.identifier.issn0303-6979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61359-
dc.descriptionThis free journal suppl. entitled: Special Issue: Abstracts of Europerio 6, 4-6 June 2009, Stockholm, Swedenen_HK
dc.descriptionPoster Abstracts: abstract no. 176 (Ref no: EUABS065655)-
dc.description.abstractPolymorphisms of host defense genes might increase ones risks for periodontitis. This study investigated single nucleotide polymorphisms (SNPs) in the coding and regulatory regions of the innate host defense element complement component 5 (C5) in association with periodontitis. 229 periodontitis patients and 207 periodontitis-free subjects were recruited for genotyping 11 tagging SNPs. AG of rs17611 was more prevalent in periodontitis patient group (P = 0.023). The haplotype CGCA of block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis (P = 0.038). Rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was significantly associated with periodontitis (P = 0.004). In conclusion, the tagging SNP rs17611 of C5, together with smoking appeared to be associated with periodontitis.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0303-6979en_HK
dc.relation.ispartofJournal of Clinical Periodontologyen_HK
dc.subjectComplement C5en_HK
dc.subjectPeriodontitisen_HK
dc.subjectPolymorphism, geneticen_HK
dc.subjectSmokingen_HK
dc.subject.meshAdenineen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAggressive Periodontitis - genetics - immunologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChronic Periodontitis - genetics - immunologyen_HK
dc.subject.meshComplement C5 - geneticsen_HK
dc.subject.meshCytosineen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequency - geneticsen_HK
dc.subject.meshGenetic Variation - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshGuanineen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunologic Factors - geneticsen_HK
dc.subject.meshIntrons - geneticsen_HK
dc.subject.meshLinkage Disequilibrium - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeriodontitis - genetics - immunologyen_HK
dc.subject.meshPolymorphism, Single Nucleotide - geneticsen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshSmokingen_HK
dc.subject.meshYoung Adulten_HK
dc.titleSingle nucleotide polymorphisms of complement component 5 and periodontitisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.emailLeung, WK:ewkleung@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.natureabstract-
dc.identifier.hkuros156320en_HK
dc.identifier.volume36en_HK
dc.identifier.issuesuppl. 9en_HK
dc.identifier.spage87, abstract no. 176en_HK
dc.identifier.epage87, abstract no. 176en_HK
dc.identifier.eissn1600-051X-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChai, L=36196100600en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridZee, KY=6603722366en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK
dc.identifier.partofdoi10.1111/j.1600-051X.2009.01404.x-
dc.identifier.issnl0303-6979-

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