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Article: A gold(III) porphyrin complex with antitumor properties targets the Wnt/β-catenin pathway

TitleA gold(III) porphyrin complex with antitumor properties targets the Wnt/β-catenin pathway
Authors
Chow, KHMSun, RWYLam, JBBLi, CKLXu, AMa, DLAbagyan, RWang, YChe, CM
Issue Date2010
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2010, v. 70 n. 1, p. 329-337 How to Cite?
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-09-3324
AbstractGold(III) complexes have shown promise as antitumor agents, but their clinical usefulness has been limited by their poor stability under physiological conditions. A novel gold(III) porphyrin complex [5-hydroxyphenyl-10,15,20- triphenylporphyrinato gold(III) chloride (gold-2a)] with improved aqueous stability showed 100-fold to 3,000-fold higher cytotoxicity than platinum-based cisplatin and IC50 values in the nanomolar range in a panel of human breast cancer cell lines. Intraductal injections of gold-2a significantly suppressed mammary tumor growth in nude mice. These effects are attributed, in part, to attenuation of Wnt/β-catenin signaling through inhibition of class I histone deacetylase (HDAC) activity. These data, in combination with computer modeling, suggest that gold-2a may represent a promising class of anticancer HDAC inhibitor preferentially targeting tumor cells with aberrant Wnt/β-catenin signaling. ©2010 AACR.
Persistent Identifierhttp://hdl.handle.net/10722/65442
ISSN
0008-5472
2021 Impact Factor: 13.312
2020 SCImago Journal Rankings: 4.103
ISI Accession Number ID
WOS:000278404300036
Funding AgencyGrant Number
University of Hong Kong
Hong Kong Research Grant CouncilHKU 777908M
HKU 779707M
University Grants Committee HKSAR
Funding Information:

Grants from Seeding Funds for Basic Research of the University of Hong Kong (Y. Wang), Hong Kong Research Grant Council grants HKU 777908M (Y. Wang) and HKU 779707M (A. Xu), and the Area of Excellent Scheme AoE/P-10-01 established under University Grants Committee HKSAR (C. Che).

References
References in Scopus
Grants
Molecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2
APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation

 

DC FieldValueLanguage
dc.contributor.authorChow, KHMen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorLam, JBBen_HK
dc.contributor.authorLi, CKLen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorMa, DLen_HK
dc.contributor.authorAbagyan, Ren_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-08-06T02:36:21Z-
dc.date.available2010-08-06T02:36:21Z-
dc.date.issued2010en_HK
dc.identifier.citationCancer Research, 2010, v. 70 n. 1, p. 329-337en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65442-
dc.description.abstractGold(III) complexes have shown promise as antitumor agents, but their clinical usefulness has been limited by their poor stability under physiological conditions. A novel gold(III) porphyrin complex [5-hydroxyphenyl-10,15,20- triphenylporphyrinato gold(III) chloride (gold-2a)] with improved aqueous stability showed 100-fold to 3,000-fold higher cytotoxicity than platinum-based cisplatin and IC50 values in the nanomolar range in a panel of human breast cancer cell lines. Intraductal injections of gold-2a significantly suppressed mammary tumor growth in nude mice. These effects are attributed, in part, to attenuation of Wnt/β-catenin signaling through inhibition of class I histone deacetylase (HDAC) activity. These data, in combination with computer modeling, suggest that gold-2a may represent a promising class of anticancer HDAC inhibitor preferentially targeting tumor cells with aberrant Wnt/β-catenin signaling. ©2010 AACR.en_HK
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshAntineoplastic Agents - pharmacology-
dc.subject.meshGold Compounds - pharmacology-
dc.subject.meshMammary Neoplasms, Experimental - drug therapy-
dc.subject.meshMetalloporphyrins - pharmacology-
dc.subject.meshSignal Transduction - drug effects-
dc.titleA gold(III) porphyrin complex with antitumor properties targets the Wnt/β-catenin pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=70&issue=1&spage=329&epage=337&date=2010&atitle=A+gold(III)+porphyrin+complex+with+antitumor+properties+targets+the+Wnt/beta-catenin+pathway-
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailMa, DL: edmondma@hku.hken_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityMa, DL=rp00760en_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-09-3324en_HK
dc.identifier.pmid19996284-
dc.identifier.scopuseid_2-s2.0-75149132744en_HK
dc.identifier.hkuros173047-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75149132744&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue1en_HK
dc.identifier.spage329en_HK
dc.identifier.epage337en_HK
dc.identifier.isiWOS:000278404300036-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectMolecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2-
dc.relation.projectAPPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation-
dc.identifier.scopusauthoridChow, KHM=26430472800en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridLam, JBB=24448474900en_HK
dc.identifier.scopusauthoridLi, CKL=14037827700en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridMa, DL=7402075538en_HK
dc.identifier.scopusauthoridAbagyan, R=7006710879en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.issnl0008-5472-

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