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Article: Vascular endothelial growth factor augments the healing of demineralized bone matrix grafts

TitleVascular endothelial growth factor augments the healing of demineralized bone matrix grafts
Authors
KeywordsBone induction
Demineralized Bone Matrix
Vascular Endothelial Growth Factor
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijsu
Citation
International Journal Of Surgery, 2006, v. 4 n. 3, p. 160-166 How to Cite?
AbstractAim: To produce a totally allogeneic graft material that would eliminate the need for harvesting the autogenous bone from patients. Materials and methods: Thirty-six (10 × 5 mm) defects were created in the parietal bones of 18 rabbits. Two experimental groups of 12 defects each were grafted with DBMIM alone and VEGF + DBMIM, respectively. The remaining 12 defects were left empty as controls, and sacrificed on days 14, 30 and 60. Two rabbits, with four defects, of each group were sacrificed on day 14, 30 and 60 post grafting. The defects were retrieved for histological evaluation and quantitative analysis. Results: No bone formed across the defect in the controls. The difference in the amount of new bone formation between experimental groups was significant especially 30 and 60 days post grafting (p < 0.0001), which were 149% and 100% respectively. Conclusion: VEGF + DBMIM powder is a promising graft material, and warrants further clinical investigation. © 2006 Surgical Associates Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/66059
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 2.895
References

 

DC FieldValueLanguage
dc.contributor.authorEmad, Ben_HK
dc.contributor.authorSherif, EMen_HK
dc.contributor.authorBasma, GMen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorBendeus, Men_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:43:14Z-
dc.date.available2010-09-06T05:43:14Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal Of Surgery, 2006, v. 4 n. 3, p. 160-166en_HK
dc.identifier.issn1743-9191en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66059-
dc.description.abstractAim: To produce a totally allogeneic graft material that would eliminate the need for harvesting the autogenous bone from patients. Materials and methods: Thirty-six (10 × 5 mm) defects were created in the parietal bones of 18 rabbits. Two experimental groups of 12 defects each were grafted with DBMIM alone and VEGF + DBMIM, respectively. The remaining 12 defects were left empty as controls, and sacrificed on days 14, 30 and 60. Two rabbits, with four defects, of each group were sacrificed on day 14, 30 and 60 post grafting. The defects were retrieved for histological evaluation and quantitative analysis. Results: No bone formed across the defect in the controls. The difference in the amount of new bone formation between experimental groups was significant especially 30 and 60 days post grafting (p < 0.0001), which were 149% and 100% respectively. Conclusion: VEGF + DBMIM powder is a promising graft material, and warrants further clinical investigation. © 2006 Surgical Associates Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijsuen_HK
dc.relation.ispartofInternational Journal of Surgeryen_HK
dc.rightsInternational Journal of Surgery. Copyright © Elsevier Ltd.en_HK
dc.subjectBone inductionen_HK
dc.subjectDemineralized Bone Matrixen_HK
dc.subjectVascular Endothelial Growth Factoren_HK
dc.titleVascular endothelial growth factor augments the healing of demineralized bone matrix graftsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1743-9191&volume=4&spage=160&epage=166&date=2006&atitle=Vascular+endothelial+growth+factor+augments+the+healing+of+demineralized+bone+matrix+graftsen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijsu.2006.04.005en_HK
dc.identifier.scopuseid_2-s2.0-33749046449en_HK
dc.identifier.hkuros125783en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749046449&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage160en_HK
dc.identifier.epage166en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEmad, B=14631644800en_HK
dc.identifier.scopusauthoridSherif, EM=36935659400en_HK
dc.identifier.scopusauthoridBasma, GM=14631767100en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridBendeus, M=6506522941en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.issnl1743-9159-

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