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Article: Neovascularization in the TMJ in response to mandibular protrusion

TitleNeovascularization in the TMJ in response to mandibular protrusion
Authors
Issue Date2003
PublisherQuintessence Publishing Co Ltd. The Journal's web site is located at http://www.quintessencepublishing.co.uk/catalog/product_info.php?cPath=3&products_id=241
Citation
The Chinese Journal of Dental Research, 2003, v. 6 n. 1, p. 28-38 How to Cite?
AbstractObjective: To examine neovascularization in the TMJ in response to mandibular forward positioning. Material and Methods: One hundred female Sprague-Dawley rats, 5 weeks of age, were divided into 5 experimental groups and 5 control groups. Functional appliances were fitted to the upper incisors of animals in the experimental groups, causing a continuous mandibular protrusion. The animals in the experimental groups, together with their matched controls, were sacrificed 3, 7, 14, 21, and 30 days after mandibular protrusion. 7-痠 sections were cut through the TMJ and were processed for immunohistochemical analysis. Neovascularization was assessed by immunostaining for endothelial cells using the monoclonal antibody EN 7/44. Immunolocalization of neovascularization was quantified using Leica Qwin system. Results: In the fibrous tissue connecting the posterior aspects of both the condyle and the glenoid fossa, the amount of immunostaining for neovascularization in the experimental groups was on average 200% higher than in the controls (P < 0.001). In the condylar bondy tissue, as well as in the bony tissue of the fossa, the amount of immunostaining for neovascularization in the experimental groups was on average 103% and 163% higher than in the controls (P < 0.001). Conclusion: Neovascularization in the TMJ is increased in response to mandibular protrusion, which is a major contributory factor to increased new bone formation in the TMJ.
Persistent Identifierhttp://hdl.handle.net/10722/66548
ISSN
2023 Impact Factor: 0.9
2023 SCImago Journal Rankings: 0.299

 

DC FieldValueLanguage
dc.contributor.authorShen, Gen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHagg, EUOen_HK
dc.contributor.authorChen, RJen_HK
dc.date.accessioned2010-09-06T05:47:17Z-
dc.date.available2010-09-06T05:47:17Z-
dc.date.issued2003en_HK
dc.identifier.citationThe Chinese Journal of Dental Research, 2003, v. 6 n. 1, p. 28-38en_HK
dc.identifier.issn1462-6446-
dc.identifier.urihttp://hdl.handle.net/10722/66548-
dc.description.abstractObjective: To examine neovascularization in the TMJ in response to mandibular forward positioning. Material and Methods: One hundred female Sprague-Dawley rats, 5 weeks of age, were divided into 5 experimental groups and 5 control groups. Functional appliances were fitted to the upper incisors of animals in the experimental groups, causing a continuous mandibular protrusion. The animals in the experimental groups, together with their matched controls, were sacrificed 3, 7, 14, 21, and 30 days after mandibular protrusion. 7-痠 sections were cut through the TMJ and were processed for immunohistochemical analysis. Neovascularization was assessed by immunostaining for endothelial cells using the monoclonal antibody EN 7/44. Immunolocalization of neovascularization was quantified using Leica Qwin system. Results: In the fibrous tissue connecting the posterior aspects of both the condyle and the glenoid fossa, the amount of immunostaining for neovascularization in the experimental groups was on average 200% higher than in the controls (P < 0.001). In the condylar bondy tissue, as well as in the bony tissue of the fossa, the amount of immunostaining for neovascularization in the experimental groups was on average 103% and 163% higher than in the controls (P < 0.001). Conclusion: Neovascularization in the TMJ is increased in response to mandibular protrusion, which is a major contributory factor to increased new bone formation in the TMJ.-
dc.languageengen_HK
dc.publisherQuintessence Publishing Co Ltd. The Journal's web site is located at http://www.quintessencepublishing.co.uk/catalog/product_info.php?cPath=3&products_id=241-
dc.relation.ispartofThe Chinese Journal of Dental Researchen_HK
dc.titleNeovascularization in the TMJ in response to mandibular protrusionen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hkusua.hku.hken_HK
dc.identifier.emailHagg, EUO: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHagg, EUO=rp00020en_HK
dc.identifier.hkuros111016en_HK
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spage28-
dc.identifier.epage38-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1462-6446-

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