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- Scopus: eid_2-s2.0-33746013789
- PMID: 16808565
- WOS: WOS:000239016800009
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Article: Matrix metalloproteinase-9 regulates graft bone resorption
Title | Matrix metalloproteinase-9 regulates graft bone resorption |
---|---|
Authors | |
Keywords | Allogenic IM bone Autogenous EC bone Autogenous IM bone Bone resorption MMP-9 |
Issue Date | 2006 |
Publisher | E H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/ |
Citation | Angle Orthodontist, 2006, v. 76 n. 4, p. 598-604 How to Cite? |
Abstract | Objective: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. Materials and Methods: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. Results: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. Conclusions: MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts. © 2005 by The EH Angle Education and Research Foundation, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/66984 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 1.446 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lu, M | en_HK |
dc.contributor.author | Rabie, ABM | en_HK |
dc.date.accessioned | 2010-09-06T05:50:59Z | - |
dc.date.available | 2010-09-06T05:50:59Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Angle Orthodontist, 2006, v. 76 n. 4, p. 598-604 | en_HK |
dc.identifier.issn | 0003-3219 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/66984 | - |
dc.description.abstract | Objective: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. Materials and Methods: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. Results: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. Conclusions: MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts. © 2005 by The EH Angle Education and Research Foundation, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | E H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/ | en_HK |
dc.relation.ispartof | Angle Orthodontist | en_HK |
dc.subject | Allogenic IM bone | en_HK |
dc.subject | Autogenous EC bone | en_HK |
dc.subject | Autogenous IM bone | en_HK |
dc.subject | Bone resorption | en_HK |
dc.subject | MMP-9 | en_HK |
dc.subject.mesh | Acid Phosphatase - analysis | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Biological Markers - analysis | en_HK |
dc.subject.mesh | Bone Marrow Transplantation - pathology | en_HK |
dc.subject.mesh | Bone Resorption - enzymology | en_HK |
dc.subject.mesh | Bone Transplantation - classification - pathology | en_HK |
dc.subject.mesh | Cytoplasm - enzymology | en_HK |
dc.subject.mesh | Gene Expression Regulation, Enzymologic | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | In Situ Hybridization | en_HK |
dc.subject.mesh | Isoenzymes - analysis | en_HK |
dc.subject.mesh | Mandible - surgery | en_HK |
dc.subject.mesh | Matrix Metalloproteinase 9 - analysis - physiology | en_HK |
dc.subject.mesh | Osteoclasts - enzymology | en_HK |
dc.subject.mesh | Periodic Acid-Schiff Reaction | en_HK |
dc.subject.mesh | RNA, Messenger - analysis | en_HK |
dc.subject.mesh | Rabbits | en_HK |
dc.subject.mesh | Time Factors | en_HK |
dc.subject.mesh | Transplantation, Autologous | en_HK |
dc.subject.mesh | Transplantation, Homologous | en_HK |
dc.title | Matrix metalloproteinase-9 regulates graft bone resorption | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-3219&volume=2006&spage=598&epage=604&date=2006&atitle=Matrix+metalloproteinase-9+regulates+graft+bone+resorption | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 16808565 | - |
dc.identifier.scopus | eid_2-s2.0-33746013789 | en_HK |
dc.identifier.hkuros | 124248 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33746013789&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 76 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 598 | en_HK |
dc.identifier.epage | 604 | en_HK |
dc.identifier.isi | WOS:000239016800009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lu, M=7402821078 | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.issnl | 0003-3219 | - |