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- Publisher Website: 10.1038/cmi.2009.110
- Scopus: eid_2-s2.0-75949099155
- PMID: 20081877
- WOS: WOS:000274323900008
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Article: Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
Title | Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma | ||||||
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Authors | |||||||
Keywords | Glaucoma IGF-1 MCP-1/CCL2 Microglia Neuroprotection | ||||||
Issue Date | 2010 | ||||||
Publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | ||||||
Citation | Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 How to Cite? | ||||||
Abstract | Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/67499 | ||||||
ISSN | 2023 Impact Factor: 21.8 2023 SCImago Journal Rankings: 4.838 | ||||||
ISI Accession Number ID |
Funding Information: This work was supported by the Glaucoma Foundation, New York, USA. Kin Chill is supported by a postdoctoral fellowship from the University of Hong Kong. | ||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chiu, K | en_HK |
dc.contributor.author | Yeung, SC | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Chang, RCC | en_HK |
dc.date.accessioned | 2010-09-06T05:55:40Z | - |
dc.date.available | 2010-09-06T05:55:40Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Cellular And Molecular Immunology, 2010, v. 7 n. 1, p. 61-68 | en_HK |
dc.identifier.issn | 1672-7681 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67499 | - |
dc.description.abstract | Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. © 2010 CSI and USTC. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | en_HK |
dc.relation.ispartof | Cellular and Molecular Immunology | en_HK |
dc.subject | Glaucoma | en_HK |
dc.subject | IGF-1 | en_HK |
dc.subject | MCP-1/CCL2 | en_HK |
dc.subject | Microglia | en_HK |
dc.subject | Neuroprotection | en_HK |
dc.subject.mesh | Cell Shape | - |
dc.subject.mesh | Chemokine CCL2 - immunology | - |
dc.subject.mesh | Glaucoma - immunology - pathology | - |
dc.subject.mesh | Microglia - immunology - pathology | - |
dc.subject.mesh | Insulin-Like Growth Factor I/immunology | - |
dc.title | Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-7681&volume=7&issue=1&spage=61&epage=68&date=2010&atitle=Modulation+of+morphological+changes+of+microglia+and+neuroprotection+by+monocyte+chemoattractant+protein-1+in+experimental+glaucoma | en_HK |
dc.identifier.email | So, KF:hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.email | Chang, RCC:rccchang@hkucc.hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.identifier.authority | Chang, RCC=rp00470 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/cmi.2009.110 | en_HK |
dc.identifier.pmid | 20081877 | - |
dc.identifier.scopus | eid_2-s2.0-75949099155 | en_HK |
dc.identifier.hkuros | 169287 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-75949099155&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 61 | en_HK |
dc.identifier.epage | 68 | en_HK |
dc.identifier.isi | WOS:000274323900008 | - |
dc.publisher.place | China | en_HK |
dc.identifier.scopusauthorid | Chiu, K=15076970500 | en_HK |
dc.identifier.scopusauthorid | Yeung, SC=25923636600 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | Chang, RCC=7403713410 | en_HK |
dc.identifier.issnl | 1672-7681 | - |