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Article: Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma

TitleHuman papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma
Authors
Si, HXTsao, SWPoon, CSPCheung, ALM
KeywordsAllelic loss
Esophageal cancer
HPV
Human papillomavirus
LOH
Loss of heterozygosity
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2004, v. 213 n. 2, p. 231-239 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2004.04.008
AbstractThe incidence/mortality rates of esophageal squamous cell carcinoma (ESCC) vary widely in different parts of China. Human papillomavirus (HPV) infection is considered a possible risk factor. Loss of heterozygosity (LOH) analysis on 87 ESCC specimens collected from three different areas of China showed lower frequency of LOH at marker D3S1621 in Linxian, an area with exceptionally high incidence of ESCC but low HPV infection rate. HPV-positive ESCC from Hong Kong, but not Sichuan, had higher frequency of LOH at D5S82 (APC, MCC), D6S497 (p21/Waf-1, HLA) and D13S260 (BRCA2) than HPV-negative samples. Our results suggest that different genetic pathways of carcinogenesis may be associated with geographic differences in risk factors. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67734
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSi, HXen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorPoon, CSPen_HK
dc.contributor.authorCheung, ALMen_HK
dc.date.accessioned2010-09-06T05:57:46Z-
dc.date.available2010-09-06T05:57:46Z-
dc.date.issued2004en_HK
dc.identifier.citationCancer Letters, 2004, v. 213 n. 2, p. 231-239en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67734-
dc.description.abstractThe incidence/mortality rates of esophageal squamous cell carcinoma (ESCC) vary widely in different parts of China. Human papillomavirus (HPV) infection is considered a possible risk factor. Loss of heterozygosity (LOH) analysis on 87 ESCC specimens collected from three different areas of China showed lower frequency of LOH at marker D3S1621 in Linxian, an area with exceptionally high incidence of ESCC but low HPV infection rate. HPV-positive ESCC from Hong Kong, but not Sichuan, had higher frequency of LOH at D5S82 (APC, MCC), D6S497 (p21/Waf-1, HLA) and D13S260 (BRCA2) than HPV-negative samples. Our results suggest that different genetic pathways of carcinogenesis may be associated with geographic differences in risk factors. © 2004 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAllelic loss-
dc.subjectEsophageal cancer-
dc.subjectHPV-
dc.subjectHuman papillomavirus-
dc.subjectLOH-
dc.subjectLoss of heterozygosity-
dc.subject.meshCarcinoma, Squamous Cell - epidemiology - genetics - virologyen_HK
dc.subject.meshCell Transformation, Neoplasticen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshEsophageal Neoplasms - epidemiology - genetics - virologyen_HK
dc.subject.meshGeographyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshLoss of Heterozygosityen_HK
dc.subject.meshPapillomaviridae - pathogenicityen_HK
dc.subject.meshPapillomavirus Infections - complicationsen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleHuman papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=213&spage=231&epage=239&date=2004&atitle=Human+papillomavirus+infection+and+loss+of+heterozygosity+in+esophageal+squamous+cell+carcinomaen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityCheung, ALM=rp00332en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2004.04.008en_HK
dc.identifier.pmid15327839-
dc.identifier.scopuseid_2-s2.0-4344665576en_HK
dc.identifier.hkuros94770en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344665576&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume213en_HK
dc.identifier.issue2en_HK
dc.identifier.spage231en_HK
dc.identifier.epage239en_HK
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridSi, HX=36780537100en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridPoon, CSP=7202672697en_HK
dc.identifier.scopusauthoridCheung, ALM=7401806497en_HK
dc.identifier.issnl0304-3835-

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