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Article: Nitric oxide synthase inhibitor attenuates number of regenerating spinal motoneurons in adult rats

TitleNitric oxide synthase inhibitor attenuates number of regenerating spinal motoneurons in adult rats
Authors
Chu, THWu, WT
KeywordsMotoneuron
Nitric oxide synthase
Regeneration
Root avulsion
Spinal cord
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2006, v. 17 n. 10, p. 969-973 How to Cite?
DOI: http://dx.doi.org/10.1097/01.wnr.0000221839.05008.85
AbstractNeuronal survival and death-related effects of nitric oxide synthase are widely studied, yet its potential involvement in regeneration remains largely unexplored. In the present study, the regenerative role of nitric oxide synthase in injured motoneurons was investigated. A ventral root was avulsed and a piece of peripheral nerve was implanted into the spinal cord. Results showed that nitric oxide synthase inhibitor reduced the number of regenerating motoneurons to half compared with sham-operated control at 2 weeks and 4 weeks after injury, but the rate of axonal regeneration was not affected. Our study adds a new line of evidence that expression of nitric oxide synthase is beneficial to the axonal regeneration of the injured spinal motoneurons. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67769
ISSN
0959-4965
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.459
ISI Accession Number ID
WOS:000239213000005
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChu, THen_HK
dc.contributor.authorWu, WTen_HK
dc.date.accessioned2010-09-06T05:58:05Z-
dc.date.available2010-09-06T05:58:05Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroreport, 2006, v. 17 n. 10, p. 969-973en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67769-
dc.description.abstractNeuronal survival and death-related effects of nitric oxide synthase are widely studied, yet its potential involvement in regeneration remains largely unexplored. In the present study, the regenerative role of nitric oxide synthase in injured motoneurons was investigated. A ventral root was avulsed and a piece of peripheral nerve was implanted into the spinal cord. Results showed that nitric oxide synthase inhibitor reduced the number of regenerating motoneurons to half compared with sham-operated control at 2 weeks and 4 weeks after injury, but the rate of axonal regeneration was not affected. Our study adds a new line of evidence that expression of nitric oxide synthase is beneficial to the axonal regeneration of the injured spinal motoneurons. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectMotoneuron-
dc.subjectNitric oxide synthase-
dc.subjectRegeneration-
dc.subjectRoot avulsion-
dc.subjectSpinal cord-
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Count - methodsen_HK
dc.subject.meshDextrans - diagnostic useen_HK
dc.subject.meshEnzyme Inhibitors - pharmacologyen_HK
dc.subject.meshGene Expression Regulation - drug effectsen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMotor Neurons - drug effectsen_HK
dc.subject.meshNerve Regeneration - drug effectsen_HK
dc.subject.meshNitric Oxide Synthase - antagonists & inhibitors - physiologyen_HK
dc.subject.meshPeripheral Nerves - transplantationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor, Nerve Growth Factor - metabolismen_HK
dc.subject.meshRhodamines - diagnostic useen_HK
dc.subject.meshSpinal Cord Injuries - pathology - physiopathology - surgeryen_HK
dc.subject.meshStilbamidines - diagnostic useen_HK
dc.subject.meshTime Factorsen_HK
dc.titleNitric oxide synthase inhibitor attenuates number of regenerating spinal motoneurons in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=17&spage=969&epage=973&date=2006&atitle=Nitric+oxide+synthase+inhibitor+attenuates+number+of+regenerating+spinal+motoneurons+in+adult+ratsen_HK
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, WT=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.wnr.0000221839.05008.85en_HK
dc.identifier.pmid16791086-
dc.identifier.scopuseid_2-s2.0-33745472917en_HK
dc.identifier.hkuros137844en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745472917&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue10en_HK
dc.identifier.spage969en_HK
dc.identifier.epage973en_HK
dc.identifier.isiWOS:000239213000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, TH=14023966500en_HK
dc.identifier.scopusauthoridWu, WT=7407081122en_HK
dc.identifier.issnl0959-4965-

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