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Article: Diadenosine polyphosphate analogue modulates signal transduction in hippocampal slices

TitleDiadenosine polyphosphate analogue modulates signal transduction in hippocampal slices
Authors
Mel'nyk, SIWright, MTanner, JATsintsadze, TSTsintsadze, VPMiller, EDLozova, NO
Issue Date2006
Citation
Fiziolohichnyǐ Zhurnal (Kiev, Ukraine : 1994), 2006, v. 52 n. 4, p. 9-12 How to Cite?
AbstractThe modulatory effect of endogenous diadenosine polyphosphates on synaptic transmission in the rat hippocampal slices has been re-examined with a non-hydrolysable Ap4A analogue diadenosine-5',5'>>-P1,P4-[beta,gamma-methylene]tetraphosphate (AppCH2ppA). We have shown that AppCH2ppA at low micromolar concentrations induce inhibition of orthodromically evoked population spikes, without affecting of excitatory postsynaptic currents and antidromic spikes recorded in the CA1 zone of hippocampus. Such a spatially selective neuronal inhibition may influence dendritic electrogenesis in pyramidal neurons and consequently mediate control of neuronal network activity in hippocampus.
Persistent Identifierhttp://hdl.handle.net/10722/68053

 

DC FieldValueLanguage
dc.contributor.authorMel'nyk, SIen_HK
dc.contributor.authorWright, Men_HK
dc.contributor.authorTanner, JAen_HK
dc.contributor.authorTsintsadze, TSen_HK
dc.contributor.authorTsintsadze, VPen_HK
dc.contributor.authorMiller, EDen_HK
dc.contributor.authorLozova, NOen_HK
dc.date.accessioned2010-09-06T06:00:53Z-
dc.date.available2010-09-06T06:00:53Z-
dc.date.issued2006en_HK
dc.identifier.citationFiziolohichnyǐ Zhurnal (Kiev, Ukraine : 1994), 2006, v. 52 n. 4, p. 9-12en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68053-
dc.description.abstractThe modulatory effect of endogenous diadenosine polyphosphates on synaptic transmission in the rat hippocampal slices has been re-examined with a non-hydrolysable Ap4A analogue diadenosine-5',5'>>-P1,P4-[beta,gamma-methylene]tetraphosphate (AppCH2ppA). We have shown that AppCH2ppA at low micromolar concentrations induce inhibition of orthodromically evoked population spikes, without affecting of excitatory postsynaptic currents and antidromic spikes recorded in the CA1 zone of hippocampus. Such a spatially selective neuronal inhibition may influence dendritic electrogenesis in pyramidal neurons and consequently mediate control of neuronal network activity in hippocampus.en_HK
dc.languageengen_HK
dc.relation.ispartofFiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994)en_HK
dc.subject.meshAction Potentials - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDinucleoside Phosphates - pharmacology - physiologyen_HK
dc.subject.meshElectric Stimulationen_HK
dc.subject.meshElectrodesen_HK
dc.subject.meshHippocampus - drug effects - physiologyen_HK
dc.subject.meshPatch-Clamp Techniquesen_HK
dc.subject.meshPyramidal Cells - drug effects - physiologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Wistaren_HK
dc.subject.meshSynaptic Transmission - drug effects - physiologyen_HK
dc.titleDiadenosine polyphosphate analogue modulates signal transduction in hippocampal slicesen_HK
dc.typeArticleen_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16958210-
dc.identifier.scopuseid_2-s2.0-33748987361en_HK
dc.identifier.hkuros135724en_HK
dc.identifier.volume52en_HK
dc.identifier.issue4en_HK
dc.identifier.spage9en_HK
dc.identifier.epage12en_HK
dc.identifier.scopusauthoridMel'nyk, SI=14630495600en_HK
dc.identifier.scopusauthoridWright, M=11139776500en_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK
dc.identifier.scopusauthoridTsintsadze, TS=6602181172en_HK
dc.identifier.scopusauthoridTsintsadze, VP=14039705700en_HK
dc.identifier.scopusauthoridMiller, ED=14630689800en_HK
dc.identifier.scopusauthoridLozova, NO=6507817041en_HK

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