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- PMID: 17006924
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Article: Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma
Title | Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma |
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Authors | |
Issue Date | 2006 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ |
Citation | Hepatology, 2006, v. 44 n. 4, p. 881-890 How to Cite? |
Abstract | Tensins are a new family of proteins that act as an important link among extracellular matrix, actin cytoskeleton, and signal transduction and have been implicated in human cancers. Tensin2 was initially identified in a search for new tensin family members that share extensive sequence homology with tensin1. Tensin2 was highly expressed in liver tissues. A recent study reported that one of the splicing variants of tensin2, variant 3, promotes cell migration. In the present study, we aimed to elucidate the role of variant 3 in hepatocarcinogenesis by assessing the expression of variant 3 mRNA in hepatocellular carcinoma (HCC) tissue and ectopically expressing variant 3 in HCC cell lines. Analysis of variant 3 expression in human HCC tissue revealed it was overexpressed in 46% (23/50) of tumor tissues as compared with the corresponding nontumorous livers. High expression of variant 3 was significantly associated with venous invasion (P = .037), tumor microsatellite formation (P = .022), and tumor nonencapsulation (P = .049). Our ectopic expression study showed that variant 3 significantly promoted the cell growth and motility of HCC cells. The clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants. Variant 3 expression also enhanced the proliferation rate in culture and in vivo tumorigenicity in nude mice. In conclusion, we reveal a novel role for variant 3 in the progression of HCC and suggest the feasibility of elevated variant 3 expression as a tumor progression marker for HCC. Copyright © 2006 by the American Association for the Study of Liver Diseases. |
Persistent Identifier | http://hdl.handle.net/10722/68162 |
ISSN | 2023 Impact Factor: 12.9 2023 SCImago Journal Rankings: 5.011 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yam, JWP | en_HK |
dc.contributor.author | Ko, FCF | en_HK |
dc.contributor.author | Chan, CY | en_HK |
dc.contributor.author | Yau, TO | en_HK |
dc.contributor.author | Tung, EKK | en_HK |
dc.contributor.author | Leung, THY | en_HK |
dc.contributor.author | Jin, DY | en_HK |
dc.contributor.author | Ng, IOL | en_HK |
dc.date.accessioned | 2010-09-06T06:01:57Z | - |
dc.date.available | 2010-09-06T06:01:57Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Hepatology, 2006, v. 44 n. 4, p. 881-890 | en_HK |
dc.identifier.issn | 0270-9139 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/68162 | - |
dc.description.abstract | Tensins are a new family of proteins that act as an important link among extracellular matrix, actin cytoskeleton, and signal transduction and have been implicated in human cancers. Tensin2 was initially identified in a search for new tensin family members that share extensive sequence homology with tensin1. Tensin2 was highly expressed in liver tissues. A recent study reported that one of the splicing variants of tensin2, variant 3, promotes cell migration. In the present study, we aimed to elucidate the role of variant 3 in hepatocarcinogenesis by assessing the expression of variant 3 mRNA in hepatocellular carcinoma (HCC) tissue and ectopically expressing variant 3 in HCC cell lines. Analysis of variant 3 expression in human HCC tissue revealed it was overexpressed in 46% (23/50) of tumor tissues as compared with the corresponding nontumorous livers. High expression of variant 3 was significantly associated with venous invasion (P = .037), tumor microsatellite formation (P = .022), and tumor nonencapsulation (P = .049). Our ectopic expression study showed that variant 3 significantly promoted the cell growth and motility of HCC cells. The clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants. Variant 3 expression also enhanced the proliferation rate in culture and in vivo tumorigenicity in nude mice. In conclusion, we reveal a novel role for variant 3 in the progression of HCC and suggest the feasibility of elevated variant 3 expression as a tumor progression marker for HCC. Copyright © 2006 by the American Association for the Study of Liver Diseases. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ | en_HK |
dc.relation.ispartof | Hepatology | en_HK |
dc.rights | Hepatology. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Carcinoma, Hepatocellular - pathology | en_HK |
dc.subject.mesh | Cell Line | en_HK |
dc.subject.mesh | Cell Movement - physiology | en_HK |
dc.subject.mesh | Cells, Cultured | en_HK |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Liver Neoplasms - metabolism - pathology | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Mice, Nude | en_HK |
dc.subject.mesh | Microfilament Proteins - genetics - metabolism | en_HK |
dc.subject.mesh | Neoplasm Invasiveness | en_HK |
dc.subject.mesh | Phosphoprotein Phosphatases - metabolism | en_HK |
dc.subject.mesh | Phosphoric Monoester Hydrolases - genetics - metabolism | en_HK |
dc.subject.mesh | RNA, Messenger - metabolism | en_HK |
dc.subject.mesh | Transfection | en_HK |
dc.subject.mesh | Tumor Markers, Biological - genetics - metabolism | en_HK |
dc.title | Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=44&spage=881&epage=890&date=2006&atitle=Tensin2+variant+3+is+associated+with+aggressive+tumor+behavior+in+human+hepatocellular+carcinoma | en_HK |
dc.identifier.email | Yam, JWP:judyyam@pathology.hku.hk | en_HK |
dc.identifier.email | Jin, DY:dyjin@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, IOL:iolng@hkucc.hku.hk | en_HK |
dc.identifier.authority | Yam, JWP=rp00468 | en_HK |
dc.identifier.authority | Jin, DY=rp00452 | en_HK |
dc.identifier.authority | Ng, IOL=rp00335 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/hep.21339 | en_HK |
dc.identifier.pmid | 17006924 | - |
dc.identifier.scopus | eid_2-s2.0-33750631858 | en_HK |
dc.identifier.hkuros | 128651 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33750631858&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 44 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 881 | en_HK |
dc.identifier.epage | 890 | en_HK |
dc.identifier.eissn | 1527-3350 | - |
dc.identifier.isi | WOS:000241338200014 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yam, JWP=6603711123 | en_HK |
dc.identifier.scopusauthorid | Ko, FCF=14630572500 | en_HK |
dc.identifier.scopusauthorid | Chan, CY=8277448300 | en_HK |
dc.identifier.scopusauthorid | Yau, TO=7006540669 | en_HK |
dc.identifier.scopusauthorid | Tung, EKK=7003519614 | en_HK |
dc.identifier.scopusauthorid | Leung, THY=7202110922 | en_HK |
dc.identifier.scopusauthorid | Jin, DY=7201973614 | en_HK |
dc.identifier.scopusauthorid | Ng, IOL=7102753722 | en_HK |
dc.identifier.issnl | 0270-9139 | - |