File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development

TitleDifferential and overlapping expression pattern of SOX2 and SOX9 in inner ear development
Authors
KeywordsHair cells
Inner ear
Otocyst
Sensory epithelia
SOX2
SOX9
Spiral ganglion
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgep
Citation
Gene Expression Patterns, 2009, v. 9 n. 6, p. 444-453 How to Cite?
AbstractThe development of the inner ear involves complex processes of morphological changes, patterning and cell fate specification that are under strict molecular control. SOX2 and SOX9 are SOX family transcription factors that are involved in the regulation of one or more of these processes. Previous findings have shown early expression of SOX9 in the otic placode and vesicle at E8.5-E9.5. Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule. SOX2 persistently marked the prosensory and sensory epithelia. During the development of the sensory epithelia, SOX2 was initially expressed in all prosensory regions and later in both the supporting and hair cells up to E15.5, when its expression in hair cells gradually diminished. SOX9 expression overlapped with that of SOX2 in the prosensory and sensory region until E14.5 when its expression was restricted to supporting cells. This initial overlap but subsequent differential expression of SOX2 and SOX9 in the sensory epithelia, suggest that SOX2 and SOX9 may have distinct roles in molecular pathways that direct cells towards different cell fates. © 2009 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/68212
ISSN
2023 Impact Factor: 1.0
2023 SCImago Journal Rankings: 0.318
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU7222/97M
HKU2/02C
HKU4/05C
Funding Information:

This work was supported by the Research Grants Council of Hong Kong (HKU7222/97M, HKU2/02C, and HKU4/05C).

References

 

DC FieldValueLanguage
dc.contributor.authorMak, ACYen_HK
dc.contributor.authorSzeto, IYYen_HK
dc.contributor.authorFritzsch, Ben_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2010-09-06T06:02:25Z-
dc.date.available2010-09-06T06:02:25Z-
dc.date.issued2009en_HK
dc.identifier.citationGene Expression Patterns, 2009, v. 9 n. 6, p. 444-453en_HK
dc.identifier.issn1567-133Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68212-
dc.description.abstractThe development of the inner ear involves complex processes of morphological changes, patterning and cell fate specification that are under strict molecular control. SOX2 and SOX9 are SOX family transcription factors that are involved in the regulation of one or more of these processes. Previous findings have shown early expression of SOX9 in the otic placode and vesicle at E8.5-E9.5. Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule. SOX2 persistently marked the prosensory and sensory epithelia. During the development of the sensory epithelia, SOX2 was initially expressed in all prosensory regions and later in both the supporting and hair cells up to E15.5, when its expression in hair cells gradually diminished. SOX9 expression overlapped with that of SOX2 in the prosensory and sensory region until E14.5 when its expression was restricted to supporting cells. This initial overlap but subsequent differential expression of SOX2 and SOX9 in the sensory epithelia, suggest that SOX2 and SOX9 may have distinct roles in molecular pathways that direct cells towards different cell fates. © 2009 Elsevier B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgepen_HK
dc.relation.ispartofGene Expression Patternsen_HK
dc.subjectHair cellsen_HK
dc.subjectInner earen_HK
dc.subjectOtocysten_HK
dc.subjectSensory epitheliaen_HK
dc.subjectSOX2en_HK
dc.subjectSOX9en_HK
dc.subjectSpiral ganglionen_HK
dc.titleDifferential and overlapping expression pattern of SOX2 and SOX9 in inner ear developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1567-133X&volume=9&issue=6&spage=444&epage=453&date=2009&atitle=Differential+and+overlapping+expression+pattern+of+SOX2+and+SOX9+in+inner+ear+developmenten_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.gep.2009.04.003en_HK
dc.identifier.pmid19427409-
dc.identifier.pmcidPMC3023882-
dc.identifier.scopuseid_2-s2.0-67651036206en_HK
dc.identifier.hkuros163194en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67651036206&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue6en_HK
dc.identifier.spage444en_HK
dc.identifier.epage453en_HK
dc.identifier.isiWOS:000269273700008-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMak, ACY=36780323700en_HK
dc.identifier.scopusauthoridSzeto, IYY=6602491785en_HK
dc.identifier.scopusauthoridFritzsch, B=7006714975en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.citeulike5122677-
dc.identifier.issnl1567-133X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats