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- Publisher Website: 10.1007/s00247-001-0582-6
- Scopus: eid_2-s2.0-0036934752
- PMID: 11819066
- WOS: WOS:000173546000013
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Article: Childhood acute disseminated encephalomyelitis: The role of brain and spinal cord MRI
Title | Childhood acute disseminated encephalomyelitis: The role of brain and spinal cord MRI |
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Authors | |
Keywords | Acute disseminated encephalomyelitis Childhood Clinical outcome MRI |
Issue Date | 2002 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00247/index.htm |
Citation | Pediatric Radiology, 2002, v. 32 n. 1, p. 59-66 How to Cite? |
Abstract | Background. It is recognised that the clinical and radiological spectrum of childhood acute disseminated encephalomyelitis (ADEM) is wide. Objective. To determine whether initial MRI features are predictive of clinical outcome and to determine the role of MRI in the management of ADEM. Materials and Methods. The MRI scans of ten consecutive children (eight boys, two girls), clinically and radiologically diagnosed to have ADEM, were retrospectively reviewed. Follow-up MRI was available for eight patients. Results. Lesions ranged from small and punctate (<1 cm) to moderate sized and confluent (4-5 cm) to diffuse and extensive. Spinal cord lesions, seen in five of seven children, were contiguous or segmental. Seven children (70%) made good clinical recovery while three children (30%) remained severely handicapped. There was no correlation between the site, extent and pattern of involvement and clinical outcome. However, the evolution of MRI findings on follow-up correlated well with the subsequent clinical course and outcome. Conclusions. Although the extent and site of lesions on initial MRI scans are not predictive of clinical outcome, early MRI of the brain and spine is useful in aiding clinical diagnosis, and subsequent follow-up MRI is helpful in monitoring disease progression. |
Persistent Identifier | http://hdl.handle.net/10722/72385 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.680 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khong, PL | en_HK |
dc.contributor.author | Ho, HK | en_HK |
dc.contributor.author | Cheng, PW | en_HK |
dc.contributor.author | Wong, VCN | en_HK |
dc.contributor.author | Goh, W | en_HK |
dc.contributor.author | Chan, FL | en_HK |
dc.date.accessioned | 2010-09-06T06:41:11Z | - |
dc.date.available | 2010-09-06T06:41:11Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Pediatric Radiology, 2002, v. 32 n. 1, p. 59-66 | en_HK |
dc.identifier.issn | 0301-0449 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/72385 | - |
dc.description.abstract | Background. It is recognised that the clinical and radiological spectrum of childhood acute disseminated encephalomyelitis (ADEM) is wide. Objective. To determine whether initial MRI features are predictive of clinical outcome and to determine the role of MRI in the management of ADEM. Materials and Methods. The MRI scans of ten consecutive children (eight boys, two girls), clinically and radiologically diagnosed to have ADEM, were retrospectively reviewed. Follow-up MRI was available for eight patients. Results. Lesions ranged from small and punctate (<1 cm) to moderate sized and confluent (4-5 cm) to diffuse and extensive. Spinal cord lesions, seen in five of seven children, were contiguous or segmental. Seven children (70%) made good clinical recovery while three children (30%) remained severely handicapped. There was no correlation between the site, extent and pattern of involvement and clinical outcome. However, the evolution of MRI findings on follow-up correlated well with the subsequent clinical course and outcome. Conclusions. Although the extent and site of lesions on initial MRI scans are not predictive of clinical outcome, early MRI of the brain and spine is useful in aiding clinical diagnosis, and subsequent follow-up MRI is helpful in monitoring disease progression. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00247/index.htm | en_HK |
dc.relation.ispartof | Pediatric Radiology | en_HK |
dc.subject | Acute disseminated encephalomyelitis | en_HK |
dc.subject | Childhood | en_HK |
dc.subject | Clinical outcome | en_HK |
dc.subject | MRI | en_HK |
dc.subject.mesh | Adolescent | en_HK |
dc.subject.mesh | Brain - pathology | en_HK |
dc.subject.mesh | Child | en_HK |
dc.subject.mesh | Child, Preschool | en_HK |
dc.subject.mesh | Encephalomyelitis, Acute Disseminated - pathology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Infant | en_HK |
dc.subject.mesh | Magnetic Resonance Imaging | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Predictive Value of Tests | en_HK |
dc.subject.mesh | Retrospective Studies | en_HK |
dc.subject.mesh | Spinal Cord - pathology | en_HK |
dc.title | Childhood acute disseminated encephalomyelitis: The role of brain and spinal cord MRI | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0449&volume=32&spage=59&epage=66&date=2002&atitle=Childhood+acute+disseminated+encephalomyelitis:+the+role+of+brain+and+spinal+cord+MRI | en_HK |
dc.identifier.email | Khong, PL:plkhong@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, VCN:vcnwong@hku.hk | en_HK |
dc.identifier.authority | Khong, PL=rp00467 | en_HK |
dc.identifier.authority | Wong, VCN=rp00334 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00247-001-0582-6 | en_HK |
dc.identifier.pmid | 11819066 | - |
dc.identifier.scopus | eid_2-s2.0-0036934752 | en_HK |
dc.identifier.hkuros | 65292 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036934752&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 32 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 59 | en_HK |
dc.identifier.epage | 66 | en_HK |
dc.identifier.isi | WOS:000173546000013 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Khong, PL=7006693233 | en_HK |
dc.identifier.scopusauthorid | Ho, HK=7401465257 | en_HK |
dc.identifier.scopusauthorid | Cheng, PW=7401618753 | en_HK |
dc.identifier.scopusauthorid | Wong, VCN=7202525632 | en_HK |
dc.identifier.scopusauthorid | Goh, W=7005651404 | en_HK |
dc.identifier.scopusauthorid | Chan, FL=7202586444 | en_HK |
dc.identifier.issnl | 0301-0449 | - |