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Article: No evidence of replication error phenotype in primary gastric lymphoma of mucosa-associated lymphoid tissue

TitleNo evidence of replication error phenotype in primary gastric lymphoma of mucosa-associated lymphoid tissue
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1998, v. 76 n. 5, p. 635-638 How to Cite?
AbstractReplication error (RER) phenotype, caused by deficiency of DNA mismatch repair genes and revealed by widespread microsatellite instability, has been detected in subsets of a wide variety of solid tumors, but rarely in lymphomas in general. So far, the involvement of RER phenotype in the pathogenesis of gastric lymphoma of mucosa-associated lymphoid tissue (MALT) type has not been conclusively established. We therefore examined 9 microsatellite loci on 5 chromosomes [D2S123, D3S11, D3S1261, D3S1262, D3S1265, D6S262, D18S59, a CTTT(T) repeat in intron 20 of RB1 gene and a CA repeat in p53 locus] in 33 cases of primary gastric MALT lymphoma for evidence of microsatellite instability by polymerase chain reaction using primers end-labeled with [γ-33P] ATP. Although novel-length allele was observed in 7 of 33 cases (21.2%), none of these 7 cases showed changes in more than one locus. RER phenotype was scored as positive in a case when more than 1 of the 9 examined microsatellite loci showed length alterations. Accordingly, none of the 33 cases had a RER phenotype. This result suggests that the pathogenesis of gastric MALT lymphoma does not involve RER phenotype. It is consistent with the general observations in lymphomas, but is highly in contrast to a previous report showing more than 50% of MALT lymphomas with the RER phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/76596
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 2.131
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, WSen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2010-09-06T07:22:55Z-
dc.date.available2010-09-06T07:22:55Z-
dc.date.issued1998en_HK
dc.identifier.citationInternational Journal Of Cancer, 1998, v. 76 n. 5, p. 635-638en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76596-
dc.description.abstractReplication error (RER) phenotype, caused by deficiency of DNA mismatch repair genes and revealed by widespread microsatellite instability, has been detected in subsets of a wide variety of solid tumors, but rarely in lymphomas in general. So far, the involvement of RER phenotype in the pathogenesis of gastric lymphoma of mucosa-associated lymphoid tissue (MALT) type has not been conclusively established. We therefore examined 9 microsatellite loci on 5 chromosomes [D2S123, D3S11, D3S1261, D3S1262, D3S1265, D6S262, D18S59, a CTTT(T) repeat in intron 20 of RB1 gene and a CA repeat in p53 locus] in 33 cases of primary gastric MALT lymphoma for evidence of microsatellite instability by polymerase chain reaction using primers end-labeled with [γ-33P] ATP. Although novel-length allele was observed in 7 of 33 cases (21.2%), none of these 7 cases showed changes in more than one locus. RER phenotype was scored as positive in a case when more than 1 of the 9 examined microsatellite loci showed length alterations. Accordingly, none of the 33 cases had a RER phenotype. This result suggests that the pathogenesis of gastric MALT lymphoma does not involve RER phenotype. It is consistent with the general observations in lymphomas, but is highly in contrast to a previous report showing more than 50% of MALT lymphomas with the RER phenotype.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshDNA Ligases - deficiencyen_HK
dc.subject.meshDNA Replicationen_HK
dc.subject.meshDNA, Neoplasm - analysis - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, B-Cell - geneticsen_HK
dc.subject.meshLymphoma, B-Cell, Marginal Zone - geneticsen_HK
dc.subject.meshMicrosatellite Repeatsen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshStomach Neoplasms - geneticsen_HK
dc.titleNo evidence of replication error phenotype in primary gastric lymphoma of mucosa-associated lymphoid tissueen_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0215(19980529)76:5<635::AID-IJC4>3.0.CO;2-Ren_HK
dc.identifier.pmid9610718-
dc.identifier.scopuseid_2-s2.0-2642607034en_HK
dc.identifier.hkuros38474en_HK
dc.identifier.hkuros33106-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2642607034&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue5en_HK
dc.identifier.spage635en_HK
dc.identifier.epage638en_HK
dc.identifier.isiWOS:000073774500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, WS=36804007100en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.issnl0020-7136-

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