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Article: Association of the HLA A2-B46-DR9 haplotype with autoimmune thyroid dysfunction after bone marrow transplantation in Chinese patients

TitleAssociation of the HLA A2-B46-DR9 haplotype with autoimmune thyroid dysfunction after bone marrow transplantation in Chinese patients
Authors
Au, WYHawkins, BRChan, EYTLie, AKWKung, AWCLiang, RCheng, NKwong, YL
KeywordsBone marrow transplantation
HLA haplotype
Hyperthyroidism
Hypothyroidism
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2001, v. 115 n. 3, p. 660-663 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2001.03197.x
AbstractAutoimmune thyroid disease (AITD) may occur in patients after bone marrow transplantation (BMT). At a median follow-up of 4 years, among 194 allografts and 28 autografts, four patients (three allografts, one autograft) developed AITD. All carried the human leucocyte antigen (HLA) A2-B46-DR9 haplotype, strongly associated with AITD in the Chinese population. No significant thyroid disorder was detected in 190 patients without this haplotype. The frequency of AITD in BMT patients with the HLA A2-B46-DR9 haplotype was 12.5%, with a relative risk of 7.8 times that of non-carriers (P < 0.001). The risk of AITD should be recognized in recipients with high-risk HLA haplotypes, and regular screening might be warranted.
Persistent Identifierhttp://hdl.handle.net/10722/76624
ISSN
0007-1048
2021 Impact Factor: 8.615
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID
WOS:000172804900025
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorCheng, Nen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:23:12Z-
dc.date.available2010-09-06T07:23:12Z-
dc.date.issued2001en_HK
dc.identifier.citationBritish Journal Of Haematology, 2001, v. 115 n. 3, p. 660-663en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76624-
dc.description.abstractAutoimmune thyroid disease (AITD) may occur in patients after bone marrow transplantation (BMT). At a median follow-up of 4 years, among 194 allografts and 28 autografts, four patients (three allografts, one autograft) developed AITD. All carried the human leucocyte antigen (HLA) A2-B46-DR9 haplotype, strongly associated with AITD in the Chinese population. No significant thyroid disorder was detected in 190 patients without this haplotype. The frequency of AITD in BMT patients with the HLA A2-B46-DR9 haplotype was 12.5%, with a relative risk of 7.8 times that of non-carriers (P < 0.001). The risk of AITD should be recognized in recipients with high-risk HLA haplotypes, and regular screening might be warranted.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectBone marrow transplantation-
dc.subjectHLA haplotype-
dc.subjectHyperthyroidism-
dc.subjectHypothyroidism-
dc.subject.meshAdulten_HK
dc.subject.meshBone Marrow Transplantationen_HK
dc.subject.meshChinaen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHLA-A2 Antigenen_HK
dc.subject.meshHLA-B Antigensen_HK
dc.subject.meshHLA-DR Antigensen_HK
dc.subject.meshHLA-DR Serological Subtypesen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRisken_HK
dc.subject.meshThyroiditis, Autoimmune - immunologyen_HK
dc.subject.meshTransplantation, Autologousen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleAssociation of the HLA A2-B46-DR9 haplotype with autoimmune thyroid dysfunction after bone marrow transplantation in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=115&spage=660&epage=663&date=2001&atitle=Association+of+the+HLA+A2-B46-DR9+haplotype+with+autoimmune+thyroid+dysfunction+after+bone+marrow+transplantation+in+Chinese+patientsen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.2001.03197.xen_HK
dc.identifier.pmid11736951-
dc.identifier.scopuseid_2-s2.0-0035669175en_HK
dc.identifier.hkuros67012en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035669175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue3en_HK
dc.identifier.spage660en_HK
dc.identifier.epage663en_HK
dc.identifier.isiWOS:000172804900025-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLie, AKW=7004510870en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridCheng, N=36749006300en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0007-1048-

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