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- Publisher Website: 10.1016/S0046-8177(99)90149-1
- Scopus: eid_2-s2.0-0032783222
- PMID: 10414507
- WOS: WOS:000081361600019
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Article: The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia
Title | The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia |
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Authors | |
Keywords | +8 Chronic eosinophilic leukemia Cytogenetics Eosinophilic chloroma FISH |
Issue Date | 1999 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath |
Citation | Human Pathology, 1999, v. 30 n. 7, p. 864-868 How to Cite? |
Abstract | A case of chronic eosinophilic leukemia (CEL) manifesting as spinal cord compression by an extradural eosinophilic chloroma in a 32-year-old Chinese man was presented, who subsequently developed extramedullary transformation at the skin and then peritoneal cavity. Cytogenetic study of bone marrow cells at diagnosis showed a clonal karyotypic abnormality of trisomy 8 (+8), which on fluorescence in situ hybridization (FISH) was shown to be present in a clone of abnormal eosinophils, hence showing the neoplastic nature of the eosinophilic proliferation. There was another population of abnormal eosinophils that did not show +8. At blastic transformation, all blast cells in ascitic fluid were shown by FISH to harbor +8. These findings suggest that +8 in this case may have arisen from clonal evolution and is not the primary genetic event in leukemogenesis, but +8 most probably imparts a further survival advantage to the clone responsible for subsequent blastic transformation. |
Persistent Identifier | http://hdl.handle.net/10722/76677 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.936 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, SK | en_HK |
dc.contributor.author | Kwong, YL | en_HK |
dc.contributor.author | Shek, TWH | en_HK |
dc.contributor.author | Wan, TSK | en_HK |
dc.contributor.author | Chow, EYD | en_HK |
dc.contributor.author | Chan, LC | en_HK |
dc.date.accessioned | 2010-09-06T07:23:45Z | - |
dc.date.available | 2010-09-06T07:23:45Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | Human Pathology, 1999, v. 30 n. 7, p. 864-868 | en_HK |
dc.identifier.issn | 0046-8177 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/76677 | - |
dc.description.abstract | A case of chronic eosinophilic leukemia (CEL) manifesting as spinal cord compression by an extradural eosinophilic chloroma in a 32-year-old Chinese man was presented, who subsequently developed extramedullary transformation at the skin and then peritoneal cavity. Cytogenetic study of bone marrow cells at diagnosis showed a clonal karyotypic abnormality of trisomy 8 (+8), which on fluorescence in situ hybridization (FISH) was shown to be present in a clone of abnormal eosinophils, hence showing the neoplastic nature of the eosinophilic proliferation. There was another population of abnormal eosinophils that did not show +8. At blastic transformation, all blast cells in ascitic fluid were shown by FISH to harbor +8. These findings suggest that +8 in this case may have arisen from clonal evolution and is not the primary genetic event in leukemogenesis, but +8 most probably imparts a further survival advantage to the clone responsible for subsequent blastic transformation. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath | en_HK |
dc.relation.ispartof | Human Pathology | en_HK |
dc.subject | +8 | en_HK |
dc.subject | Chronic eosinophilic leukemia | en_HK |
dc.subject | Cytogenetics | en_HK |
dc.subject | Eosinophilic chloroma | en_HK |
dc.subject | FISH | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Ascites - genetics - pathology | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 8 | en_HK |
dc.subject.mesh | Chronic Disease | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hypereosinophilic Syndrome - genetics - metabolism - radiography | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | In Situ Hybridization, Fluorescence | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Peritoneal Diseases - metabolism - pathology | en_HK |
dc.subject.mesh | Skin Diseases - metabolism - pathology | en_HK |
dc.subject.mesh | Tomography, X-Ray Computed | en_HK |
dc.subject.mesh | Trisomy | en_HK |
dc.subject.mesh | Tumor Markers, Biological - metabolism | en_HK |
dc.title | The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=30&spage=864&epage=868&date=1999&atitle=The+role+of+trisomy+8+in+the+pathogenesis+of+chronic+eosinophilic+leukemia | en_HK |
dc.identifier.email | Kwong, YL:ylkwong@hku.hk | en_HK |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Kwong, YL=rp00358 | en_HK |
dc.identifier.authority | Chan, LC=rp00373 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0046-8177(99)90149-1 | en_HK |
dc.identifier.pmid | 10414507 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0032783222 | en_HK |
dc.identifier.hkuros | 41653 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032783222&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 864 | en_HK |
dc.identifier.epage | 868 | en_HK |
dc.identifier.isi | WOS:000081361600019 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ma, SK=9042504200 | en_HK |
dc.identifier.scopusauthorid | Kwong, YL=7102818954 | en_HK |
dc.identifier.scopusauthorid | Shek, TWH=7005479861 | en_HK |
dc.identifier.scopusauthorid | Wan, TSK=25623981600 | en_HK |
dc.identifier.scopusauthorid | Chow, EYD=7102595571 | en_HK |
dc.identifier.scopusauthorid | Chan, LC=7403540707 | en_HK |
dc.identifier.issnl | 0046-8177 | - |