File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma

TitleLeukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma
Authors
Au, WYChan, ECSiu, LLPLau, TCMLie, AKWMa, SKKwong, YL
KeywordsAllogeneic BMT
Donor leukaemia
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2002, v. 119 n. 3, p. 777-780 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2002.03925.x
AbstractDonor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia, which was shown to be donor-derived cytogenetically and molecularly. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT. Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia.
Persistent Identifierhttp://hdl.handle.net/10722/76906
ISSN
0007-1048
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.574
ISI Accession Number ID
WOS:000179283600031
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, ECen_HK
dc.contributor.authorSiu, LLPen_HK
dc.contributor.authorLau, TCMen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:26:11Z-
dc.date.available2010-09-06T07:26:11Z-
dc.date.issued2002en_HK
dc.identifier.citationBritish Journal Of Haematology, 2002, v. 119 n. 3, p. 777-780en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76906-
dc.description.abstractDonor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia, which was shown to be donor-derived cytogenetically and molecularly. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT. Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectAllogeneic BMT-
dc.subjectDonor leukaemia-
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshCarcinoma, Bronchogenic - complicationsen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - therapyen_HK
dc.subject.meshLeukemia, Myeloid - etiology - geneticsen_HK
dc.subject.meshLung Neoplasms - complicationsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPedigreeen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshTissue Donorsen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleLeukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=19&spage=777&epage=780&date=2002&atitle=Leukaemic+relapse+of+donor+origin+after+allogeneic+bone+marrow+transplantation+from+a+donor+who+later+developed+bronchogenic+carcinomaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.2002.03925.xen_HK
dc.identifier.pmid12437659-
dc.identifier.scopuseid_2-s2.0-0036436101en_HK
dc.identifier.hkuros77790en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036436101&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume119en_HK
dc.identifier.issue3en_HK
dc.identifier.spage777en_HK
dc.identifier.epage780en_HK
dc.identifier.isiWOS:000179283600031-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, EC=7401994120en_HK
dc.identifier.scopusauthoridSiu, LLP=35574705900en_HK
dc.identifier.scopusauthoridLau, TCM=17341008600en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0007-1048-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats