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- Publisher Website: 10.1016/j.clineuro.2004.05.001
- Scopus: eid_2-s2.0-13644259070
- PMID: 15708229
- WOS: WOS:000227317800011
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Article: Idiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis optica
Title | Idiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis optica |
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Authors | |
Keywords | Brainstem Idiopathic transverse myelitis Multiple sclerosis Neuromyelitis optica Spinal cord |
Issue Date | 2005 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuro |
Citation | Clinical Neurology And Neurosurgery, 2005, v. 107 n. 2, p. 132-135 How to Cite? |
Abstract | Recurrent idiopathic transverse myelitis occur in multiple sclerosis (MS) and neuromyelitis optica (NMO). In NMO, acute optic neuritis and myelitis occur, either monophasic or relapsing, without clinical manifestations of involvement of other parts of the central nervous system (CNS). Recent evidence suggests that NMO is different from multiple sclerosis. The authors reported two patients having severe recurrent transverse myelitis sparing the optic nerves and cerebral hemispheres. Both patients had longitudinally extensive myelitis in some attacks with poor neurological outcome despite aggressive immunomodulatory therapy. One patient had prominent clinical features of brainstem injury with radiological and histological confirmation of brainstem involvement, and the other patient had trigeminal neuralgia suggestive of possible brainstem dysfunction. Histologically, prominent necrosis and neutrophilic infiltration of spinal cord tissue without eosinophils or hyalinized vessels were observed, and oligoclonal bands were absent in their cerebrospinal fluid. It is likely to be a distinct idiopathic inflammatory demyelinating disorder restricted to the spinal cord and brainstem different from MS, but within the spectrum of NMO with probably an autoimmune basis. © 2004 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/77070 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.608 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, KH | en_HK |
dc.contributor.author | Tsang, KL | en_HK |
dc.contributor.author | Fong, GCY | en_HK |
dc.contributor.author | Cheung, RTF | en_HK |
dc.contributor.author | Ho, SL | en_HK |
dc.date.accessioned | 2010-09-06T07:27:56Z | - |
dc.date.available | 2010-09-06T07:27:56Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Clinical Neurology And Neurosurgery, 2005, v. 107 n. 2, p. 132-135 | en_HK |
dc.identifier.issn | 0303-8467 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77070 | - |
dc.description.abstract | Recurrent idiopathic transverse myelitis occur in multiple sclerosis (MS) and neuromyelitis optica (NMO). In NMO, acute optic neuritis and myelitis occur, either monophasic or relapsing, without clinical manifestations of involvement of other parts of the central nervous system (CNS). Recent evidence suggests that NMO is different from multiple sclerosis. The authors reported two patients having severe recurrent transverse myelitis sparing the optic nerves and cerebral hemispheres. Both patients had longitudinally extensive myelitis in some attacks with poor neurological outcome despite aggressive immunomodulatory therapy. One patient had prominent clinical features of brainstem injury with radiological and histological confirmation of brainstem involvement, and the other patient had trigeminal neuralgia suggestive of possible brainstem dysfunction. Histologically, prominent necrosis and neutrophilic infiltration of spinal cord tissue without eosinophils or hyalinized vessels were observed, and oligoclonal bands were absent in their cerebrospinal fluid. It is likely to be a distinct idiopathic inflammatory demyelinating disorder restricted to the spinal cord and brainstem different from MS, but within the spectrum of NMO with probably an autoimmune basis. © 2004 Elsevier B.V. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuro | en_HK |
dc.relation.ispartof | Clinical Neurology and Neurosurgery | en_HK |
dc.subject | Brainstem | en_HK |
dc.subject | Idiopathic transverse myelitis | en_HK |
dc.subject | Multiple sclerosis | en_HK |
dc.subject | Neuromyelitis optica | en_HK |
dc.subject | Spinal cord | en_HK |
dc.subject.mesh | Female | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Myelitis, Transverse - diagnosis - etiology - therapy | - |
dc.subject.mesh | Recurrence | - |
dc.subject.mesh | Severity of Illness Index | - |
dc.title | Idiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis optica | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-8467&volume=107&issue=2&spage=132&epage=135&date=2005&atitle=Idiopathic+severe+recurrent+transverse+myelitis:+a+restricted+variant+of+neuromyelitis+optica | en_HK |
dc.identifier.email | Cheung, RTF:rtcheung@hku.hk | en_HK |
dc.identifier.email | Ho, SL:slho@hku.hk | en_HK |
dc.identifier.authority | Cheung, RTF=rp00434 | en_HK |
dc.identifier.authority | Ho, SL=rp00240 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.clineuro.2004.05.001 | en_HK |
dc.identifier.pmid | 15708229 | - |
dc.identifier.scopus | eid_2-s2.0-13644259070 | en_HK |
dc.identifier.hkuros | 168588 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-13644259070&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 107 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 132 | en_HK |
dc.identifier.epage | 135 | en_HK |
dc.identifier.isi | WOS:000227317800011 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Chan, KH=7406034963 | en_HK |
dc.identifier.scopusauthorid | Tsang, KL=7201554745 | en_HK |
dc.identifier.scopusauthorid | Fong, GCY=36726526600 | en_HK |
dc.identifier.scopusauthorid | Cheung, RTF=7202397498 | en_HK |
dc.identifier.scopusauthorid | Ho, SL=25959633500 | en_HK |
dc.identifier.issnl | 0303-8467 | - |