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Article: Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease
Title | Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease |
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Authors | |
Issue Date | 2004 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT |
Citation | Alimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 How to Cite? |
Abstract | Background: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population. |
Persistent Identifier | http://hdl.handle.net/10722/77079 |
ISSN | 2023 Impact Factor: 6.6 2023 SCImago Journal Rankings: 2.794 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, WM | en_HK |
dc.contributor.author | Lai, KC | en_HK |
dc.contributor.author | Hui, WM | en_HK |
dc.contributor.author | Lam, KF | en_HK |
dc.contributor.author | Huang, JQ | en_HK |
dc.contributor.author | Hu, WHC | en_HK |
dc.contributor.author | Wong, NYH | en_HK |
dc.contributor.author | Lam, CLK | en_HK |
dc.contributor.author | Xia, HHX | en_HK |
dc.contributor.author | Chan, AOO | en_HK |
dc.contributor.author | Lam, SK | en_HK |
dc.contributor.author | Wong, BCY | en_HK |
dc.date.accessioned | 2010-09-06T07:28:02Z | - |
dc.date.available | 2010-09-06T07:28:02Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Alimentary Pharmacology And Therapeutics, 2004, v. 19 n. 4, p. 455-462 | en_HK |
dc.identifier.issn | 0269-2813 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77079 | - |
dc.description.abstract | Background: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27:17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. Conclusion: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT | en_HK |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | en_HK |
dc.rights | Alimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd. | en_HK |
dc.subject.mesh | 2-Pyridinylmethylsulfinylbenzimidazoles | en_HK |
dc.subject.mesh | Anti-Ulcer Agents - administration & dosage | en_HK |
dc.subject.mesh | China - ethnology | en_HK |
dc.subject.mesh | Cross-Over Studies | en_HK |
dc.subject.mesh | Double-Blind Method | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gastric Acidity Determination | en_HK |
dc.subject.mesh | Gastroesophageal Reflux - drug therapy - ethnology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hydrogen-Ion Concentration | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Omeprazole - administration & dosage - analogs & derivatives | en_HK |
dc.subject.mesh | Treatment Outcome | en_HK |
dc.title | Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=19&issue=4&spage=455&epage=62&date=2004&atitle=Double-blind,+Randomized+Controlled+Study+to+Assess+the+Effects+of+Lansoprazole+30+mg+and+Lansoprazole+15+mg+on+24-h+Oesophageal+and+Intragastric+pH+in+Chinese+Subjects+with+Gastro-Oesophageal+Reflux+Disease | en_HK |
dc.identifier.email | Lam, KF: hrntlkf@hkucc.hku.hk | en_HK |
dc.identifier.email | Lam, CLK: clklam@hku.hk | en_HK |
dc.identifier.email | Wong, BCY: bcywong@hku.hk | en_HK |
dc.identifier.authority | Lam, KF=rp00718 | en_HK |
dc.identifier.authority | Lam, CLK=rp00350 | en_HK |
dc.identifier.authority | Wong, BCY=rp00429 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1046/j.1365-2036.2004.01846.x | en_HK |
dc.identifier.pmid | 14871286 | - |
dc.identifier.scopus | eid_2-s2.0-10744232346 | en_HK |
dc.identifier.hkuros | 86283 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-10744232346&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 19 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 455 | en_HK |
dc.identifier.epage | 462 | en_HK |
dc.identifier.isi | WOS:000188892300010 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Wong, WM=7403972413 | en_HK |
dc.identifier.scopusauthorid | Lai, KC=7402135595 | en_HK |
dc.identifier.scopusauthorid | Hui, WM=7103196477 | en_HK |
dc.identifier.scopusauthorid | Lam, KF=8948421200 | en_HK |
dc.identifier.scopusauthorid | Huang, JQ=7403635051 | en_HK |
dc.identifier.scopusauthorid | Hu, WHC=25932937100 | en_HK |
dc.identifier.scopusauthorid | Wong, NYH=7202836655 | en_HK |
dc.identifier.scopusauthorid | Lam, CLK=24755913900 | en_HK |
dc.identifier.scopusauthorid | Xia, HHX=8757161400 | en_HK |
dc.identifier.scopusauthorid | Chan, AOO=7403167965 | en_HK |
dc.identifier.scopusauthorid | Lam, SK=7402279473 | en_HK |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_HK |
dc.identifier.issnl | 0269-2813 | - |