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- Publisher Website: 10.1002/1097-0142(20010101)91:1<106::AID-CNCR14>3.0.CO;2-2
- Scopus: eid_2-s2.0-0035173815
- PMID: 11148566
- WOS: WOS:000168675200014
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Article: Expression of c-myc, c-fos, and c-jun in hepatocellular carcinoma
Title | Expression of c-myc, c-fos, and c-jun in hepatocellular carcinoma |
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Authors | |
Keywords | Cell cycle Hepatocarcinogenesis Immunohistochemistry Proliferation |
Issue Date | 2001 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 |
Citation | Cancer, 2001, v. 91 n. 1, p. 106-112 How to Cite? |
Abstract | BACKGROUND. Increased expression of the proto-oncogene c-myc is a common phenomenon in hepatocellular carcinoma (HCC). The proto-oncogenes c-fos and c-jun are involved in cell cycle progression and cellular proliferation. METHODS. The objective of this study was to elucidate the mechanism of hepatocarcinogenesis with regard to the expressions of c-myc, c-fos, and c-jun. One hundred fifty biopsied HCC specimens were stained immunohistochemically for the above phenotypic markers both in tumor tissue and in adjacent nontumor tissue. RESULTS. Although the expression of c-myc was high (74%) in tumor tissue, it was significantly less compared with the expression in nontumor tissue (100%; P = 0.0002). The expression of c-myc was inversely proportional to the grade of differentiation in tumor tissue (P = 0.0108; correlation coefficient [r] = -0.244); that is, tissue with poorer histologic differentiation had a lower level of c-myc expression. There were inverse associations between the expression of c-myc and the expression of mutated p53 (P = 0.0017; r = -0.285) as well as the expression of Ki67 (P = 0.057; r = -0.147). There was significantly high expression of c-fos in tumor tissue compared with the expression in nontumor tissue (91% vs. 0%; P < 0.0001). Both the tumor tissue and the nontumor tissue had high levels of expression of c-jun (96.53% and 100%, respectively). There was a trend toward a positive association between the expression of c-fos and the expression of c-jun in tumor tissue (P = 0.07; r = 0.162). CONCLUSIONS. Because c-myc is a known inducer of wild type p53, decreased c-myc expression may lead to uncontrolled cell growth because of the lack of p53 expression that normally induces apoptosis. The coordinated expression of c-fos and c-jun in HCC may reflect the coordinated tumor cell cycle of progression and proliferation; however, future studies are required to elucidate this possibility. © 2001 American Cancer Society. |
Persistent Identifier | http://hdl.handle.net/10722/77346 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 2.887 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Yuen, MF | en_HK |
dc.contributor.author | Wu, PC | en_HK |
dc.contributor.author | Lai, VCH | en_HK |
dc.contributor.author | Lau, JYN | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.date.accessioned | 2010-09-06T07:30:55Z | - |
dc.date.available | 2010-09-06T07:30:55Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Cancer, 2001, v. 91 n. 1, p. 106-112 | en_HK |
dc.identifier.issn | 0008-543X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77346 | - |
dc.description.abstract | BACKGROUND. Increased expression of the proto-oncogene c-myc is a common phenomenon in hepatocellular carcinoma (HCC). The proto-oncogenes c-fos and c-jun are involved in cell cycle progression and cellular proliferation. METHODS. The objective of this study was to elucidate the mechanism of hepatocarcinogenesis with regard to the expressions of c-myc, c-fos, and c-jun. One hundred fifty biopsied HCC specimens were stained immunohistochemically for the above phenotypic markers both in tumor tissue and in adjacent nontumor tissue. RESULTS. Although the expression of c-myc was high (74%) in tumor tissue, it was significantly less compared with the expression in nontumor tissue (100%; P = 0.0002). The expression of c-myc was inversely proportional to the grade of differentiation in tumor tissue (P = 0.0108; correlation coefficient [r] = -0.244); that is, tissue with poorer histologic differentiation had a lower level of c-myc expression. There were inverse associations between the expression of c-myc and the expression of mutated p53 (P = 0.0017; r = -0.285) as well as the expression of Ki67 (P = 0.057; r = -0.147). There was significantly high expression of c-fos in tumor tissue compared with the expression in nontumor tissue (91% vs. 0%; P < 0.0001). Both the tumor tissue and the nontumor tissue had high levels of expression of c-jun (96.53% and 100%, respectively). There was a trend toward a positive association between the expression of c-fos and the expression of c-jun in tumor tissue (P = 0.07; r = 0.162). CONCLUSIONS. Because c-myc is a known inducer of wild type p53, decreased c-myc expression may lead to uncontrolled cell growth because of the lack of p53 expression that normally induces apoptosis. The coordinated expression of c-fos and c-jun in HCC may reflect the coordinated tumor cell cycle of progression and proliferation; however, future studies are required to elucidate this possibility. © 2001 American Cancer Society. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 | en_HK |
dc.relation.ispartof | Cancer | en_HK |
dc.rights | Cancer. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject | Cell cycle | - |
dc.subject | Hepatocarcinogenesis | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Proliferation | - |
dc.subject.mesh | Adolescent | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Apoptosis | en_HK |
dc.subject.mesh | Biopsy | en_HK |
dc.subject.mesh | Carcinoma, Hepatocellular - genetics - physiopathology | en_HK |
dc.subject.mesh | Cell Cycle | en_HK |
dc.subject.mesh | Cell Transformation, Neoplastic | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_HK |
dc.subject.mesh | Genes, fos - genetics | en_HK |
dc.subject.mesh | Genes, jun - genetics | en_HK |
dc.subject.mesh | Genes, myc - genetics | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Liver Neoplasms - genetics - physiopathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Phenotype | en_HK |
dc.title | Expression of c-myc, c-fos, and c-jun in hepatocellular carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=91&issue=1&spage=106&epage=112&date=2001&atitle=Expression+of+c-Myc,+c-Fos,+and+c-Jun+in+hepatocellular+carcinoma | en_HK |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/1097-0142(20010101)91:1<106::AID-CNCR14>3.0.CO;2-2 | en_HK |
dc.identifier.pmid | 11148566 | - |
dc.identifier.scopus | eid_2-s2.0-0035173815 | en_HK |
dc.identifier.hkuros | 59908 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035173815&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 91 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 106 | en_HK |
dc.identifier.epage | 112 | en_HK |
dc.identifier.isi | WOS:000168675200014 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.scopusauthorid | Wu, PC=7403119323 | en_HK |
dc.identifier.scopusauthorid | Lai, VCH=36757583700 | en_HK |
dc.identifier.scopusauthorid | Lau, JYN=7402446047 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.issnl | 0008-543X | - |