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Article: Symptom resolution does not predict healing of erosive oesophagitis in Chinese

TitleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
Authors
KeywordsGastro-oesophageal reflux disease
Oesophagitis
pH monitoring
Proton pump inhibitors
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 2007, v. 75 n. 2-3, p. 128-134 How to Cite?
AbstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/77586
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.891
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWong, NYHen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorTong, TSMen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:33:30Z-
dc.date.available2010-09-06T07:33:30Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestion, 2007, v. 75 n. 2-3, p. 128-134en_HK
dc.identifier.issn0012-2823en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77586-
dc.description.abstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_HK
dc.relation.ispartofDigestionen_HK
dc.rightsDigestion. Copyright © S Karger AG.en_HK
dc.subjectGastro-oesophageal reflux disease-
dc.subjectOesophagitis-
dc.subjectpH monitoring-
dc.subjectProton pump inhibitors-
dc.subject.meshAnti-Ulcer Agents - therapeutic useen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshChinaen_HK
dc.subject.meshEsophagitis - drug therapy - ethnologyen_HK
dc.subject.meshEsophagoscopyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastric Acidity Determinationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrogen-Ion Concentrationen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshManometryen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOmeprazole - therapeutic useen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleSymptom resolution does not predict healing of erosive oesophagitis in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-2823&volume=75&issue=2-3&spage=128&epage=134&date=2007&atitle=Symptom+Resolution+Does+Not+Predict+Healing+of+Erosive+Oesophagitis+in+Chineseen_HK
dc.identifier.emailFung, J:jfung@sicklehut.comen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000106453en_HK
dc.identifier.pmid17671381-
dc.identifier.scopuseid_2-s2.0-34548303549en_HK
dc.identifier.hkuros134098en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548303549&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage128en_HK
dc.identifier.epage134en_HK
dc.identifier.isiWOS:000249383500018-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridCheung, TK=7103334158en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWong, NYH=7202836655en_HK
dc.identifier.scopusauthoridChan, CK=7404813960en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridTong, TSM=7102587364en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.issnl0012-2823-

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