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Article: Atypical blasts and bone marrow necrosis associated with near-triploid relapse of acute promyelocytic leukemia after arsenic trioxide treatment

TitleAtypical blasts and bone marrow necrosis associated with near-triploid relapse of acute promyelocytic leukemia after arsenic trioxide treatment
Authors
Chim, CSLam, CCKWong, KFMan, CKam, SKwong, YL
KeywordsAcute promyelocytic leukemia
Marrow necrosis
Triploidy
Issue Date2002
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2002, v. 33 n. 8, p. 849-851 How to Cite?
DOI: http://dx.doi.org/10.1053/hupa.2002.125770
AbstractThe pathologic features of acute promyelocytic leukemia (APL) with t(15;17)(q22;q21) are highly characteristic, which with few exceptions enable a firm diagnosis to be made on morphologic grounds. An APL patient in first relapse presented with large, bizarre circulating blasts and bone marrow necrosis 2 weeks after chemotherapy consolidation for an arsenic trioxide-induced remission. Although a morphologic diagnosis could not be reached, cytogenetic investigations showed a near-triploid clone with t(15;17), confirming APL in second relapse. This case showed that clonal evolution with additional karyotypic aberrations might alter the blast morphology and pathologic features in APL. Copyright 2002, Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77790
ISSN
0046-8177
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.936
ISI Accession Number ID
WOS:000177726000013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorLam, CCKen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorMan, Cen_HK
dc.contributor.authorKam, Sen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:35:45Z-
dc.date.available2010-09-06T07:35:45Z-
dc.date.issued2002en_HK
dc.identifier.citationHuman Pathology, 2002, v. 33 n. 8, p. 849-851en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77790-
dc.description.abstractThe pathologic features of acute promyelocytic leukemia (APL) with t(15;17)(q22;q21) are highly characteristic, which with few exceptions enable a firm diagnosis to be made on morphologic grounds. An APL patient in first relapse presented with large, bizarre circulating blasts and bone marrow necrosis 2 weeks after chemotherapy consolidation for an arsenic trioxide-induced remission. Although a morphologic diagnosis could not be reached, cytogenetic investigations showed a near-triploid clone with t(15;17), confirming APL in second relapse. This case showed that clonal evolution with additional karyotypic aberrations might alter the blast morphology and pathologic features in APL. Copyright 2002, Elsevier Science (USA). All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectAcute promyelocytic leukemia-
dc.subjectMarrow necrosis-
dc.subjectTriploidy-
dc.subject.meshAdulten_HK
dc.subject.meshArsenicals - therapeutic useen_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshBone Marrow - pathologyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Promyelocytic, Acute - drug therapy - pathologyen_HK
dc.subject.meshNecrosisen_HK
dc.subject.meshOxides - therapeutic useen_HK
dc.subject.meshPloidiesen_HK
dc.subject.meshRecurrenceen_HK
dc.titleAtypical blasts and bone marrow necrosis associated with near-triploid relapse of acute promyelocytic leukemia after arsenic trioxide treatmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=33&issue=88&spage=849&epage=851&date=2002&atitle=Atypical+blasts+and+bone+marrow+necrosis+associated+with+near-triploid+relapse+of+acute+promyelocytic+leukemia+after+arsenic+trioxide+treatmenten_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/hupa.2002.125770en_HK
dc.identifier.pmid12203219-
dc.identifier.scopuseid_2-s2.0-0036689353en_HK
dc.identifier.hkuros77959en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036689353&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue8en_HK
dc.identifier.spage849en_HK
dc.identifier.epage851en_HK
dc.identifier.isiWOS:000177726000013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridMan, C=7005722377en_HK
dc.identifier.scopusauthoridKam, S=15767699900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0046-8177-

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