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Article: Biomechanical properties of thin skin flap after basic fibroblast growth factor (bFGF) administration

TitleBiomechanical properties of thin skin flap after basic fibroblast growth factor (bFGF) administration
Authors
KeywordsBasic fibroblast growth factor
Biomechanical properties
Rat model
Skin flaps
Issue Date2000
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/707671/description#description
Citation
British Journal Of Plastic Surgery, 2000, v. 53 n. 3, p. 225-229 How to Cite?
AbstractThis study is designed to examine the effects of basic fibroblast growth factor (bFGF) administration on the biomechanical properties of thin skin flap healing. A total of 42 rats were used in this study, and skin flaps 10 cm long by 3 cm wide were raised in 28 rats. One injection of bFGF was applied at three different times (immediately postoperatively, and 24 h and 48 h postoperatively) between the flap and wound bed of 14 rats (the bFGF treated group), while the other 14 rats with flaps had the same tissue culture medium treatment but without bFGF (the untreated group). The remaining 14 rats without flaps constituted the control group (normal group). The rats were killed 10 days postoperatively, and 1.0 cm x 6.0 cm sections of the skin flap taken for mechanical and histological testing. The load, deformation and tensile strength at failure were recorded. The average flap survival area in the bFGF treated group was 27 cm2, significantly higher (P < 0.001) than that seen in the untreated group. The average elastic stiffness of the skin flap in the bFGF treated group was also observed to be higher than in the untreated group although this difference was not significant. The mean tensile strength of the bFGF treated group (61 N) was significantly higher than the untreated group (38 N, P < 0.01) however. Despite this, the tensile strengths at failure of both of these groups were found to be significantly lower than that of normal skin (101 N, P < 0.01). A relaxation in load of about 8% was seen in specimens from the normal group and the bFGF treated group, while the untreated group showed a relaxation of about 15%. (C) 2000 The British Association of Plastic Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/79355
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, WWen_HK
dc.contributor.authorIp, WYen_HK
dc.contributor.authorJing, WMen_HK
dc.contributor.authorHolmes, ADen_HK
dc.contributor.authorChow, SPen_HK
dc.date.accessioned2010-09-06T07:53:45Z-
dc.date.available2010-09-06T07:53:45Z-
dc.date.issued2000en_HK
dc.identifier.citationBritish Journal Of Plastic Surgery, 2000, v. 53 n. 3, p. 225-229en_HK
dc.identifier.issn0007-1226en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79355-
dc.description.abstractThis study is designed to examine the effects of basic fibroblast growth factor (bFGF) administration on the biomechanical properties of thin skin flap healing. A total of 42 rats were used in this study, and skin flaps 10 cm long by 3 cm wide were raised in 28 rats. One injection of bFGF was applied at three different times (immediately postoperatively, and 24 h and 48 h postoperatively) between the flap and wound bed of 14 rats (the bFGF treated group), while the other 14 rats with flaps had the same tissue culture medium treatment but without bFGF (the untreated group). The remaining 14 rats without flaps constituted the control group (normal group). The rats were killed 10 days postoperatively, and 1.0 cm x 6.0 cm sections of the skin flap taken for mechanical and histological testing. The load, deformation and tensile strength at failure were recorded. The average flap survival area in the bFGF treated group was 27 cm2, significantly higher (P < 0.001) than that seen in the untreated group. The average elastic stiffness of the skin flap in the bFGF treated group was also observed to be higher than in the untreated group although this difference was not significant. The mean tensile strength of the bFGF treated group (61 N) was significantly higher than the untreated group (38 N, P < 0.01) however. Despite this, the tensile strengths at failure of both of these groups were found to be significantly lower than that of normal skin (101 N, P < 0.01). A relaxation in load of about 8% was seen in specimens from the normal group and the bFGF treated group, while the untreated group showed a relaxation of about 15%. (C) 2000 The British Association of Plastic Surgeons.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/707671/description#descriptionen_HK
dc.relation.ispartofBritish Journal of Plastic Surgeryen_HK
dc.subjectBasic fibroblast growth factoren_HK
dc.subjectBiomechanical propertiesen_HK
dc.subjectRat modelen_HK
dc.subjectSkin flapsen_HK
dc.titleBiomechanical properties of thin skin flap after basic fibroblast growth factor (bFGF) administrationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1226&volume=53&spage=225&epage=229&date=2000&atitle=Biomechanical+properties+of+thin+skin+flap+after+basic+fibroblast+growth+factor+(bFGF)+administrationen_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.emailIp, WY: wyip@hku.hken_HK
dc.identifier.emailChow, SP: spchow@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityIp, WY=rp00401en_HK
dc.identifier.authorityChow, SP=rp00064en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1054/bjps.1999.3264en_HK
dc.identifier.pmid10738329en_HK
dc.identifier.scopuseid_2-s2.0-0033998147en_HK
dc.identifier.hkuros49394en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033998147&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage225en_HK
dc.identifier.epage229en_HK
dc.identifier.isiWOS:000086525300010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridIp, WY=35549641700en_HK
dc.identifier.scopusauthoridJing, WM=7006423369en_HK
dc.identifier.scopusauthoridHolmes, AD=7401687268en_HK
dc.identifier.scopusauthoridChow, SP=7201828376en_HK
dc.identifier.issnl0007-1226-

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