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Article: Combined factor V and factor VIII deficiency in a girl with haemarthrosis
Title | Combined factor V and factor VIII deficiency in a girl with haemarthrosis |
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Authors | |
Keywords | Clotting proteins Factor V deficiency Factor VIII deficiency Haemarthrosis Haemophilia |
Issue Date | 1996 |
Publisher | Medcom Limited. |
Citation | Hong Kong Journal of Paediatrics, 1996, v. 1 n. 1, p. 70-73 How to Cite? |
Abstract | Factor VIII and factor V are clotting proteins acting as cofactors respectively for factor IX in the intrinsic pathway and factor X in the common pathway of the coagulation cascade. Haemophilia A due to factor VIII deficiency is transmitted as an X-linked disease occurring in 1 in 10,000 males. Factor V deficiency alone is rare and is autosomal recessive with an estimated incidence of 1 in a million persons. Combined factor V and factor VIII deficiency is also rare but is the commonest of the inherited deficiencies of more than one coagulation factors. We describe a 5 year old Chinese girl who presented with haemarthrosis and diagnosed to have combined factor V and VIII deficiencies. She was found to have prolonged activated partial thromboplastin time and prolonged prothrombin time. Factor assays showed low factor V level of 0.14 u/ml and low factor VIII level of 0.20 u/ml. Her symptoms subsided with infusion of fresh frozen plasma. Over a 2 year follow up period, she has been free from further major bleeding. |
Persistent Identifier | http://hdl.handle.net/10722/79978 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
DC Field | Value | Language |
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dc.contributor.author | Wei, DCC | en_HK |
dc.contributor.author | Ha, SY | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2010-09-06T08:00:58Z | - |
dc.date.available | 2010-09-06T08:00:58Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Hong Kong Journal of Paediatrics, 1996, v. 1 n. 1, p. 70-73 | en_HK |
dc.identifier.issn | 1013-9923 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/79978 | - |
dc.description.abstract | Factor VIII and factor V are clotting proteins acting as cofactors respectively for factor IX in the intrinsic pathway and factor X in the common pathway of the coagulation cascade. Haemophilia A due to factor VIII deficiency is transmitted as an X-linked disease occurring in 1 in 10,000 males. Factor V deficiency alone is rare and is autosomal recessive with an estimated incidence of 1 in a million persons. Combined factor V and factor VIII deficiency is also rare but is the commonest of the inherited deficiencies of more than one coagulation factors. We describe a 5 year old Chinese girl who presented with haemarthrosis and diagnosed to have combined factor V and VIII deficiencies. She was found to have prolonged activated partial thromboplastin time and prolonged prothrombin time. Factor assays showed low factor V level of 0.14 u/ml and low factor VIII level of 0.20 u/ml. Her symptoms subsided with infusion of fresh frozen plasma. Over a 2 year follow up period, she has been free from further major bleeding. | - |
dc.language | eng | en_HK |
dc.publisher | Medcom Limited. | en_HK |
dc.relation.ispartof | Hong Kong Journal of Paediatrics | en_HK |
dc.subject | Clotting proteins | - |
dc.subject | Factor V deficiency | - |
dc.subject | Factor VIII deficiency | - |
dc.subject | Haemarthrosis | - |
dc.subject | Haemophilia | - |
dc.title | Combined factor V and factor VIII deficiency in a girl with haemarthrosis | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=1&issue=1&spage=70&epage=73&date=1996&atitle=Combined+factor+V+and+factor+VIII+deficiency+in+a+girl+with+haemarthrosis | en_HK |
dc.identifier.email | Ha, SY: syha@hkucc.hku.hk | en_HK |
dc.identifier.email | Lau, YL: lauylung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 14096 | en_HK |
dc.identifier.issnl | 1013-9923 | - |