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- Publisher Website: 10.1016/S1071-5576(03)00149-7
- Scopus: eid_2-s2.0-0345528877
- PMID: 14662162
- WOS: WOS:000187209100007
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Article: 5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure
Title | 5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure |
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Authors | |
Keywords | 5-hydroxytryptamine Human umbilical arteries Thromboxane A2 Umbilical cord closure Vasoconstriction |
Issue Date | 2003 |
Publisher | Sage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com |
Citation | Journal Of The Society For Gynecologic Investigation, 2003, v. 10 n. 8, p. 490-495 How to Cite? |
Abstract | OBJECTIVE: This study investigated the response of the human umbilical artery to various agonists in order to determine which agents might be involved in umbilical cord closure. METHODS: Umbilical artery rings from 22 cesarean deliveries were suspended in tissue baths containing Krebs-Henseleit solution under low and normal oxygen conditions. Samples were challenged with 5-hydroxytryptamine, acetylcholine, angiotensin II, bradykinin, endothelin-1, histamine, norepinephrine, phenylephrine, and U46619 (a thromboxane A 2 mimetic). RESULTS: Only 5-hydroxytryptamine, bradykinin, endothelin-1, histamine, and U46619 produced appreciable maximal contractions. Furthermore, although the contractile force generated by these agonists was diminished in normal oxygen conditions, this reduction affected responses to 5-hydroxytryptamine and U46619 least. CONCLUSION: 5-Hydroxytryptamine and U46619 demonstrated the characteristics most likely to be associated with closure of the umbilical artery, ie, they elicited strong, sustained contractions at physiologic concentrations and under both normal and low-oxygen conditions. These data suggest that closure of the umbilical artery may be mediated by 5-hydroxytryptamine and thromboxane A2. Copyright © 2003 by the Society for Gynecologic Investigation. |
Persistent Identifier | http://hdl.handle.net/10722/80290 |
ISSN | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Quan, A | en_HK |
dc.contributor.author | Leung, SWS | en_HK |
dc.contributor.author | Lao, TT | en_HK |
dc.contributor.author | Man, RYK | en_HK |
dc.date.accessioned | 2010-09-06T08:04:40Z | - |
dc.date.available | 2010-09-06T08:04:40Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Journal Of The Society For Gynecologic Investigation, 2003, v. 10 n. 8, p. 490-495 | en_HK |
dc.identifier.issn | 1071-5576 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/80290 | - |
dc.description.abstract | OBJECTIVE: This study investigated the response of the human umbilical artery to various agonists in order to determine which agents might be involved in umbilical cord closure. METHODS: Umbilical artery rings from 22 cesarean deliveries were suspended in tissue baths containing Krebs-Henseleit solution under low and normal oxygen conditions. Samples were challenged with 5-hydroxytryptamine, acetylcholine, angiotensin II, bradykinin, endothelin-1, histamine, norepinephrine, phenylephrine, and U46619 (a thromboxane A 2 mimetic). RESULTS: Only 5-hydroxytryptamine, bradykinin, endothelin-1, histamine, and U46619 produced appreciable maximal contractions. Furthermore, although the contractile force generated by these agonists was diminished in normal oxygen conditions, this reduction affected responses to 5-hydroxytryptamine and U46619 least. CONCLUSION: 5-Hydroxytryptamine and U46619 demonstrated the characteristics most likely to be associated with closure of the umbilical artery, ie, they elicited strong, sustained contractions at physiologic concentrations and under both normal and low-oxygen conditions. These data suggest that closure of the umbilical artery may be mediated by 5-hydroxytryptamine and thromboxane A2. Copyright © 2003 by the Society for Gynecologic Investigation. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Sage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com | en_HK |
dc.relation.ispartof | Journal of the Society for Gynecologic Investigation | en_HK |
dc.rights | Journal of the Society for Gynecologic Investigation. Copyright © Sage Publications, Inc. | en_HK |
dc.subject | 5-hydroxytryptamine | en_HK |
dc.subject | Human umbilical arteries | en_HK |
dc.subject | Thromboxane A2 | en_HK |
dc.subject | Umbilical cord closure | en_HK |
dc.subject | Vasoconstriction | en_HK |
dc.title | 5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1071-5576&volume=10&issue=8&spage=490&epage=495&date=2003&atitle=5-Hydroxytryptamine+and+Thromboxane+A2+as+Physiologic+Mediators+of+Human+Umbilical+Artery+Closure | en_HK |
dc.identifier.email | Leung, SWS: swsleung@hku.hk | en_HK |
dc.identifier.email | Man, RYK: rykman@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SWS=rp00235 | en_HK |
dc.identifier.authority | Man, RYK=rp00236 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S1071-5576(03)00149-7 | en_HK |
dc.identifier.pmid | 14662162 | - |
dc.identifier.scopus | eid_2-s2.0-0345528877 | en_HK |
dc.identifier.hkuros | 85973 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0345528877&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 10 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 490 | en_HK |
dc.identifier.epage | 495 | en_HK |
dc.identifier.isi | WOS:000187209100007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Quan, A=7006871453 | en_HK |
dc.identifier.scopusauthorid | Leung, SWS=24540419500 | en_HK |
dc.identifier.scopusauthorid | Lao, TT=35275381600 | en_HK |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_HK |
dc.identifier.issnl | 1071-5576 | - |