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Article: The distribution and gene expression of adrenomedullin in the rat brain: Peptide/mRNA and precursor/active peptide relationships

TitleThe distribution and gene expression of adrenomedullin in the rat brain: Peptide/mRNA and precursor/active peptide relationships
Authors
Hwang, ISSTang, F
KeywordsAdrenomedullin
Brain
Gel-filtration chromatography
Pituitary
Radioimmunoassay
Solutionhybridisation- RNase protection assay
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1999, v. 267 n. 2, p. 85-88 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3940(99)00320-1
AbstractThe highest immunoreactive adrenomedullin (AM) concentrations were found in the pituitary gland, hypothalamus and brainstem. Rat preproadrenomedullin mRNA levels were highest in the pituitary, followed by the hypothalamus. The peptide to mRNA ratios are higher in the neurointermediate lobe, brainstem and hypothalamus. Immunocytochemical study showed discrete localization of AM immunostaining in various brain regions including the cerebral cortex, hypothalamus and brainstem and in the pituitary gland. By gel filtration chromatography, the precursor peaks were low in the pituitary, hypothalamus and brainstem but high in other brain regions.
Persistent Identifierhttp://hdl.handle.net/10722/81095
ISSN
0304-3940
2021 Impact Factor: 3.197
2020 SCImago Journal Rankings: 0.944
ISI Accession Number ID
WOS:000080531300003
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T08:13:45Z-
dc.date.available2010-09-06T08:13:45Z-
dc.date.issued1999en_HK
dc.identifier.citationNeuroscience Letters, 1999, v. 267 n. 2, p. 85-88en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81095-
dc.description.abstractThe highest immunoreactive adrenomedullin (AM) concentrations were found in the pituitary gland, hypothalamus and brainstem. Rat preproadrenomedullin mRNA levels were highest in the pituitary, followed by the hypothalamus. The peptide to mRNA ratios are higher in the neurointermediate lobe, brainstem and hypothalamus. Immunocytochemical study showed discrete localization of AM immunostaining in various brain regions including the cerebral cortex, hypothalamus and brainstem and in the pituitary gland. By gel filtration chromatography, the precursor peaks were low in the pituitary, hypothalamus and brainstem but high in other brain regions.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAdrenomedullinen_HK
dc.subjectBrainen_HK
dc.subjectGel-filtration chromatographyen_HK
dc.subjectPituitaryen_HK
dc.subjectRadioimmunoassayen_HK
dc.subjectSolutionhybridisation- RNase protection assayen_HK
dc.titleThe distribution and gene expression of adrenomedullin in the rat brain: Peptide/mRNA and precursor/active peptide relationshipsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=267&spage=85&epage=88&date=1999&atitle=The+distribution+and+gene+expression+of+adrenomedullin+in+the+rat+brain:+peptide/mRNA+and+precursor/active+peptide+relationshipsen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(99)00320-1en_HK
dc.identifier.pmid10400218-
dc.identifier.scopuseid_2-s2.0-0033612256en_HK
dc.identifier.hkuros44869en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033612256&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume267en_HK
dc.identifier.issue2en_HK
dc.identifier.spage85en_HK
dc.identifier.epage88en_HK
dc.identifier.isiWOS:000080531300003-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.issnl0304-3940-

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