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Article: Autoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis

TitleAutoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis
Authors
Shiu, SYWChow, PHYu, ZHTang, FPang, SF
Keywordsautoradiography
constant light
corpus epididymidis
melatonin receptor
rhythm
testosterone
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1996, v. 59 n. 14, p. 1165-1174 How to Cite?
DOI: http://dx.doi.org/10.1016/0024-3205(96)00434-1
AbstractAutoradiographic study was conducted to localize 2-[ 125I]iodomelatonin binding in the rat epididymis. In the peripubertal (6 weeks old), postpubertal (8 weeks old) and adult (3 months old) rats, intense specific 2-[ 125I]iodomelatonin labelling of the corpus epididymidis was observed. The intensity of 2-[ 125I]iodomelatonin binding in the distal epididymal segment was significantly decreased in orchidectomized rats but the effect could be reversed with testosterone replacement. The intensity of 2-[ 125I]iodomelatonin binding in the distal rat epididymal segment did not show any diurnal rhythmicity when mid-light period and mid-dark period levels were compared, and was unaffected by constant lighting. Our data suggest androgen-dependent expression of 2-[ 125I]iodomelatonin binding sites, independent of light-induced changes in circulating melatonin, in the rat corpus epididymidis. A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated.
Persistent Identifierhttp://hdl.handle.net/10722/81100
ISSN
0024-3205
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID
WOS:A1996VE89900008
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorChow, PHen_HK
dc.contributor.authorYu, ZHen_HK
dc.contributor.authorTang, Fen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T08:13:49Z-
dc.date.available2010-09-06T08:13:49Z-
dc.date.issued1996en_HK
dc.identifier.citationLife Sciences, 1996, v. 59 n. 14, p. 1165-1174en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81100-
dc.description.abstractAutoradiographic study was conducted to localize 2-[ 125I]iodomelatonin binding in the rat epididymis. In the peripubertal (6 weeks old), postpubertal (8 weeks old) and adult (3 months old) rats, intense specific 2-[ 125I]iodomelatonin labelling of the corpus epididymidis was observed. The intensity of 2-[ 125I]iodomelatonin binding in the distal epididymal segment was significantly decreased in orchidectomized rats but the effect could be reversed with testosterone replacement. The intensity of 2-[ 125I]iodomelatonin binding in the distal rat epididymal segment did not show any diurnal rhythmicity when mid-light period and mid-dark period levels were compared, and was unaffected by constant lighting. Our data suggest androgen-dependent expression of 2-[ 125I]iodomelatonin binding sites, independent of light-induced changes in circulating melatonin, in the rat corpus epididymidis. A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectautoradiographyen_HK
dc.subjectconstant lighten_HK
dc.subjectcorpus epididymidisen_HK
dc.subjectmelatonin receptoren_HK
dc.subjectrhythmen_HK
dc.subjecttestosteroneen_HK
dc.titleAutoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=59&spage=1165&epage=1174&date=1996&atitle=Autoradiographic+distribution+and+physiological+regulation+of+2-[125I]iodomelatonin+binding+in+rat+epididymisen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0024-3205(96)00434-1en_HK
dc.identifier.pmid8831804-
dc.identifier.scopuseid_2-s2.0-0030606799en_HK
dc.identifier.hkuros20910en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030606799&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue14en_HK
dc.identifier.spage1165en_HK
dc.identifier.epage1174en_HK
dc.identifier.isiWOS:A1996VE89900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridChow, PH=7202656919en_HK
dc.identifier.scopusauthoridYu, ZH=7404346841en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.issnl0024-3205-

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