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- Publisher Website: 10.1007/s001250050965
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- PMID: 9662047
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Article: Streptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assay
Title | Streptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assay |
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Authors | |
Keywords | Atrial natriuretic peptide Rat Solution-hybridization-RNase protection assay Streptozotocin |
Issue Date | 1998 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm |
Citation | Diabetologia, 1998, v. 41 n. 6, p. 660-665 How to Cite? |
Abstract | In rats with streptozotocin (STZ)-diabetes for 2 or 4 weeks, the atrial natriuretic peptide (ANP) concentrations in the atria decreased whilst that of ANP in the plasma and ventricles increased. ANP concentrations in the hypothalamus and in the brainstem did not change in either 2- or 4-week diabetic rats. Atrial ANP content was partly restored by insulin replacement in 4-week diabetic rats. Plasma ANP concentrations and ventricular ANP contents were reversed to normal by insulin treatment in both 2- and 4-week diabetic rats. Solution-hybridization-RNase-protection assay showed a significant increase in the preproANP mRNA expression in the ventricles but not in the atria. These results indicated that the STZ-diabetes increased the synthesis of ANP in the ventricles and consequently its release from the ventricles. The synthesis of ANP in the atria did not change as judged from the preproANP mRNA expression but the release of ANP from the atria might also be increased for ANP content decreased in the atria. The reason for the difference in the response of atrial and ventricular preproANP concentrations to STZ-diabetes is not known. |
Persistent Identifier | http://hdl.handle.net/10722/81186 |
ISSN | 2023 Impact Factor: 8.4 2023 SCImago Journal Rankings: 3.355 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wu, SQ | en_HK |
dc.contributor.author | Kwan, CY | en_HK |
dc.contributor.author | Tang, F | en_HK |
dc.date.accessioned | 2010-09-06T08:14:48Z | - |
dc.date.available | 2010-09-06T08:14:48Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Diabetologia, 1998, v. 41 n. 6, p. 660-665 | en_HK |
dc.identifier.issn | 0012-186X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/81186 | - |
dc.description.abstract | In rats with streptozotocin (STZ)-diabetes for 2 or 4 weeks, the atrial natriuretic peptide (ANP) concentrations in the atria decreased whilst that of ANP in the plasma and ventricles increased. ANP concentrations in the hypothalamus and in the brainstem did not change in either 2- or 4-week diabetic rats. Atrial ANP content was partly restored by insulin replacement in 4-week diabetic rats. Plasma ANP concentrations and ventricular ANP contents were reversed to normal by insulin treatment in both 2- and 4-week diabetic rats. Solution-hybridization-RNase-protection assay showed a significant increase in the preproANP mRNA expression in the ventricles but not in the atria. These results indicated that the STZ-diabetes increased the synthesis of ANP in the ventricles and consequently its release from the ventricles. The synthesis of ANP in the atria did not change as judged from the preproANP mRNA expression but the release of ANP from the atria might also be increased for ANP content decreased in the atria. The reason for the difference in the response of atrial and ventricular preproANP concentrations to STZ-diabetes is not known. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm | en_HK |
dc.relation.ispartof | Diabetologia | en_HK |
dc.subject | Atrial natriuretic peptide | en_HK |
dc.subject | Rat | en_HK |
dc.subject | Solution-hybridization-RNase protection assay | en_HK |
dc.subject | Streptozotocin | en_HK |
dc.title | Streptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assay | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-186X&volume=41&spage=660&epage=665&date=1998&atitle=Streptozotocin-induced+diabetes+has+differential+effects+on+atrial+natriuretic+peptide+synthesis+in+the+rat+atrium+and+ventricle:+a+study++by+solution-hybridization+RNase+protection+assay | en_HK |
dc.identifier.email | Tang, F: ftang@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tang, F=rp00327 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s001250050965 | en_HK |
dc.identifier.pmid | 9662047 | - |
dc.identifier.scopus | eid_2-s2.0-0031812694 | en_HK |
dc.identifier.hkuros | 36682 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031812694&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 41 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 660 | en_HK |
dc.identifier.epage | 665 | en_HK |
dc.identifier.isi | WOS:000074102000008 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Wu, SQ=7407180073 | en_HK |
dc.identifier.scopusauthorid | Kwan, CY=7201421224 | en_HK |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_HK |
dc.identifier.issnl | 0012-186X | - |