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- Publisher Website: 10.1111/j.1440-1681.1995.tb02965.x
- Scopus: eid_2-s2.0-0029617697
- PMID: 9072439
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Conference Paper: Elevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive rats
Title | Elevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive rats |
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Authors | |
Keywords | Blood pressure Hypertension Kainic acid Neuronal firing pattern Ventrolateral medulla |
Issue Date | 1995 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1995, v. 22 suppl. 1, p. S46-S47 How to Cite? |
Abstract | 1. The caudal ventrolateral medulla (CVLM) of pentobarbital-anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats was identified by the depressor response with microinjection of glutamate. 2. The mean firing rate of the spontaneously active phenylephrine-excited CVLM neurons was significantly greater in SHR than in WKY. The pattern of neuronal firing in terms of coefficient of variation and skewness of the interspike interval histogram was similar in both types of rats. 3. Administration to CVLM of kainic acid, an excitotoxic agent, led to a biphasic blood pressure response - a transient reduction followed by a gradual and sustained elevation. The elevation in blood pressure was significantly greater in SHR than in WKY. 4. These findings suggest that the barosensitive CVLM neurons are more active and the tonic inhibitory influence from CVLM to rostral ventrolateral medulla (RVLM) is greater in SHR than in WKY. It is therefore not likely that the elevated spontaneous activity of the RVLM cardiovascular neurons in SHR is due to a smaller inhibitory influence from CVLM. |
Persistent Identifier | http://hdl.handle.net/10722/81286 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
DC Field | Value | Language |
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dc.contributor.author | Wong, TM | en_HK |
dc.contributor.author | Yang, Z | en_HK |
dc.contributor.author | Chan, YS | en_HK |
dc.creator | sml 170620 amended | - |
dc.date.accessioned | 2010-09-06T08:15:56Z | - |
dc.date.available | 2010-09-06T08:15:56Z | - |
dc.date.issued | 1995 | en_HK |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1995, v. 22 suppl. 1, p. S46-S47 | en_HK |
dc.identifier.issn | 0305-1870 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/81286 | - |
dc.description.abstract | 1. The caudal ventrolateral medulla (CVLM) of pentobarbital-anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats was identified by the depressor response with microinjection of glutamate. 2. The mean firing rate of the spontaneously active phenylephrine-excited CVLM neurons was significantly greater in SHR than in WKY. The pattern of neuronal firing in terms of coefficient of variation and skewness of the interspike interval histogram was similar in both types of rats. 3. Administration to CVLM of kainic acid, an excitotoxic agent, led to a biphasic blood pressure response - a transient reduction followed by a gradual and sustained elevation. The elevation in blood pressure was significantly greater in SHR than in WKY. 4. These findings suggest that the barosensitive CVLM neurons are more active and the tonic inhibitory influence from CVLM to rostral ventrolateral medulla (RVLM) is greater in SHR than in WKY. It is therefore not likely that the elevated spontaneous activity of the RVLM cardiovascular neurons in SHR is due to a smaller inhibitory influence from CVLM. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_HK |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_HK |
dc.subject | Blood pressure | en_HK |
dc.subject | Hypertension | en_HK |
dc.subject | Kainic acid | en_HK |
dc.subject | Neuronal firing pattern | en_HK |
dc.subject | Ventrolateral medulla | en_HK |
dc.title | Elevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive rats | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=&issue=Suppl 1&spage=S16&epage=&date=1994&atitle=Elevated+spontaneous+activity+of+phenylephrine-excited+neurons+in+the+caudal+ventrolateral+medulla+of+spontaneously+hypertensive+rats | en_HK |
dc.identifier.email | Chan, YS: yschan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, YS=rp00318 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1440-1681.1995.tb02965.x | - |
dc.identifier.pmid | 9072439 | - |
dc.identifier.scopus | eid_2-s2.0-0029617697 | en_HK |
dc.identifier.hkuros | 3062 | en_HK |
dc.identifier.volume | 22 | en_HK |
dc.identifier.issue | suppl. 1 | en_HK |
dc.identifier.spage | S46 | en_HK |
dc.identifier.epage | S47 | en_HK |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Wong, TM=7403531434 | en_HK |
dc.identifier.scopusauthorid | Yang, Z=16742980200 | en_HK |
dc.identifier.scopusauthorid | Chan, YS=7403676627 | en_HK |
dc.identifier.issnl | 0305-1870 | - |