File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts

TitleHeterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts
Authors
KeywordsCardiac electrophysiology
Heterogeneity
Na+ current
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmcc
Citation
Journal Of Molecular And Cellular Cardiology, 2002, v. 34 n. 9, p. 1185-1194 How to Cite?
AbstractThe different sodium channel currents (INa) were reported in myocardium, neuron, and skeletal muscles. To study whether INa is homogeneous within the heart, we applied whole-cell voltage clamp technique to evaluate fast voltage-gated INa in atrial and ventricular myocytes isolated from guinea pig heart. It was found that the density of inward INa was 50% greater at -35mV in atrial (-42.64 ± 2.9 pA/pF) than in ventricular (-27.5 ± 1.8 pA/pF, P < 0.01) myocytes. The half activation and inactivation voltages (V0.5) of INa in atrial myocytes were shifted 4.5 ± 0.2 and 9.6 ± 0.3 mV negative to those of ventricular myocytes. Time constants for INa activation (τm) and inactivation (τh) were twice as rapid in atrial as in ventricular myocytes. The τm and τh were 0.34 ± 0.03 and 1.36 ± 0.07 ms for atrial myocytes, and 0.69 ± 0.05 and 3.27 ± 0.23 ms for ventricular myocytes, respectively. Recovery of INa from inactivation was slower in atrial than in ventricular myocytes, whereas the development of resting state inactivation was more rapid in atrial (τ = 67.5 ± 4.3 ms) than in ventricular (152.8 ± 7.5 ms, P < 0.01) myocytes. The results reveal marked heterogeneity of INa in the density and biophysical properties in atrial and ventricular myocytes, and the study suggests the potential possibility of tissue specific cardiac sodium channel isoforms. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81328
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.639
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorShrier, Aen_HK
dc.date.accessioned2010-09-06T08:16:24Z-
dc.date.available2010-09-06T08:16:24Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Molecular And Cellular Cardiology, 2002, v. 34 n. 9, p. 1185-1194en_HK
dc.identifier.issn0022-2828en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81328-
dc.description.abstractThe different sodium channel currents (INa) were reported in myocardium, neuron, and skeletal muscles. To study whether INa is homogeneous within the heart, we applied whole-cell voltage clamp technique to evaluate fast voltage-gated INa in atrial and ventricular myocytes isolated from guinea pig heart. It was found that the density of inward INa was 50% greater at -35mV in atrial (-42.64 ± 2.9 pA/pF) than in ventricular (-27.5 ± 1.8 pA/pF, P < 0.01) myocytes. The half activation and inactivation voltages (V0.5) of INa in atrial myocytes were shifted 4.5 ± 0.2 and 9.6 ± 0.3 mV negative to those of ventricular myocytes. Time constants for INa activation (τm) and inactivation (τh) were twice as rapid in atrial as in ventricular myocytes. The τm and τh were 0.34 ± 0.03 and 1.36 ± 0.07 ms for atrial myocytes, and 0.69 ± 0.05 and 3.27 ± 0.23 ms for ventricular myocytes, respectively. Recovery of INa from inactivation was slower in atrial than in ventricular myocytes, whereas the development of resting state inactivation was more rapid in atrial (τ = 67.5 ± 4.3 ms) than in ventricular (152.8 ± 7.5 ms, P < 0.01) myocytes. The results reveal marked heterogeneity of INa in the density and biophysical properties in atrial and ventricular myocytes, and the study suggests the potential possibility of tissue specific cardiac sodium channel isoforms. © 2002 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmccen_HK
dc.relation.ispartofJournal of Molecular and Cellular Cardiologyen_HK
dc.subjectCardiac electrophysiologyen_HK
dc.subjectHeterogeneityen_HK
dc.subjectNa+ currenten_HK
dc.subject.meshAction Potentials-
dc.subject.meshHeart Atria - metabolism-
dc.subject.meshHeart Ventricles - metabolism-
dc.subject.meshSodium - metabolism-
dc.subject.meshSodium Channels - metabolism-
dc.titleHeterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig heartsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2828&volume=34&issue=9&spage=1185&epage=1194&date=2002&atitle=Heterogeneity+of+sodium+current+in+atrial+vs+epicardial+ventricular+myocytes+of+adult+guinea+pig+heartsen_HK
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_HK
dc.identifier.authorityLi, GR=rp00476en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0022-2828(02)92053-5en_HK
dc.identifier.pmid12392892en_HK
dc.identifier.scopuseid_2-s2.0-0036750798en_HK
dc.identifier.hkuros81907en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036750798&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1185en_HK
dc.identifier.epage1194en_HK
dc.identifier.isiWOS:000178622500014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, GR=7408462932en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridShrier, A=7005657095en_HK
dc.identifier.issnl0022-2828-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats