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- Publisher Website: 10.1007/s004060070036
- Scopus: eid_2-s2.0-0034108937
- PMID: 10853920
- WOS: WOS:000087396100002
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Article: A five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECT
Title | A five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECT |
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Authors | |
Keywords | Clozapine Schizophrenia SPECT Treatment resistant |
Issue Date | 2000 |
Publisher | Dr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.link.springer.de/link/service/journals/00406/index.htm |
Citation | European Archives Of Psychiatry And Clinical Neuroscience, 2000, v. 250 n. 2, p. 69-72 How to Cite? |
Abstract | This is a naturalistic study of the relationship between cerebral metabolic activity, clinical symptoms and treatment response in a schizophrenic patient for 5 years from the onset of her illness. Serial technetium-99m-HM-PAO brain SPECT was used to measure regional cerebral metabolism. The Cambridge Neurological Inventory and neuropsychological tests (WAIS-R verbal subscales, Wisconsin Card Sorting Test, semantic verbal fluency, logical memory in Weschler Memory Scale) were used for neurocognitive assessment. Under-activity of the left temporal area was observed in the course of patient illness despite remission of the psychotic symptoms. Bilateral prefrontal metabolic under-activity was noted at the emergence of negative symptoms, executive neurocognitive dysfunction and the treatment-resistant state. After response to clozapine, the right prefrontal activity returned to a normal level. Our findings suggested that persistent left temporal underactivity detected by SPECT despite clinical remission may indicate a vulnerability for further relapses and development of a treatment-resistant state. Treatment-resistant state, negative symptoms and executive neurocognitive deficit may involve abnormal prefrontal metabolic activity and can be alleviated in clozapine-responsive patients. |
Persistent Identifier | http://hdl.handle.net/10722/81639 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.381 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, RYL | en_HK |
dc.contributor.author | Chen, E | en_HK |
dc.contributor.author | Ho, WY | en_HK |
dc.date.accessioned | 2010-09-06T08:20:12Z | - |
dc.date.available | 2010-09-06T08:20:12Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | European Archives Of Psychiatry And Clinical Neuroscience, 2000, v. 250 n. 2, p. 69-72 | en_HK |
dc.identifier.issn | 0940-1334 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/81639 | - |
dc.description.abstract | This is a naturalistic study of the relationship between cerebral metabolic activity, clinical symptoms and treatment response in a schizophrenic patient for 5 years from the onset of her illness. Serial technetium-99m-HM-PAO brain SPECT was used to measure regional cerebral metabolism. The Cambridge Neurological Inventory and neuropsychological tests (WAIS-R verbal subscales, Wisconsin Card Sorting Test, semantic verbal fluency, logical memory in Weschler Memory Scale) were used for neurocognitive assessment. Under-activity of the left temporal area was observed in the course of patient illness despite remission of the psychotic symptoms. Bilateral prefrontal metabolic under-activity was noted at the emergence of negative symptoms, executive neurocognitive dysfunction and the treatment-resistant state. After response to clozapine, the right prefrontal activity returned to a normal level. Our findings suggested that persistent left temporal underactivity detected by SPECT despite clinical remission may indicate a vulnerability for further relapses and development of a treatment-resistant state. Treatment-resistant state, negative symptoms and executive neurocognitive deficit may involve abnormal prefrontal metabolic activity and can be alleviated in clozapine-responsive patients. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Dr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.link.springer.de/link/service/journals/00406/index.htm | en_HK |
dc.relation.ispartof | European Archives of Psychiatry and Clinical Neuroscience | en_HK |
dc.subject | Clozapine | en_HK |
dc.subject | Schizophrenia | en_HK |
dc.subject | SPECT | en_HK |
dc.subject | Treatment resistant | en_HK |
dc.title | A five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECT | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-1334&volume=250&spage=69&epage=72&date=2000&atitle=A+Five-year+longitudinal+study+of+the+regional+cerebral+metabolic+changes+of+a+schizophrenic+patient | en_HK |
dc.identifier.email | Chen, E: eyhchen@hku.hk | en_HK |
dc.identifier.email | Chen, RYL: rylchen@hkucc.hku.hk | - |
dc.identifier.authority | Chen, E=rp00392 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s004060070036 | - |
dc.identifier.pmid | 10853920 | - |
dc.identifier.scopus | eid_2-s2.0-0034108937 | en_HK |
dc.identifier.hkuros | 53431 | en_HK |
dc.identifier.hkuros | 61695 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034108937&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 250 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 69 | en_HK |
dc.identifier.epage | 72 | en_HK |
dc.identifier.isi | WOS:000087396100002 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Chen, RYL=16635066600 | en_HK |
dc.identifier.scopusauthorid | Chen, E=7402315729 | en_HK |
dc.identifier.scopusauthorid | Ho, WY=25938053100 | en_HK |
dc.identifier.issnl | 0940-1334 | - |